{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:01:18Z","timestamp":1754485278293,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Pleomorphic adenomas (PAs) are the most common benign salivary neoplasms. PAs are generally slow-growing but may sometimes become aggressive and grow rapidly within a short period of time. Here, we report the case of an 83-year-old Chinese woman with an anterior neck mass that had been growing over the past 30 years. She felt uncomfortable because the mass had grown quite rapidly in the past year. The final diagnosis of a PA of the left submandibular gland was confirmed by histopathological and immunohistochemical examinations after surgical resection. Our patient recalled a history of an excision of a neck mass 40 years prior to presentation at another hospital. Based on our imaging findings and surgical findings, we speculate that the neck mass 40 years prior may also have been a PA. Our case reminds us the rare recurrence possibility of PAs, and early and thorough resection may have a good prognosis. In addition, to the best of our knowledge, this is the largest PA of the submandibular gland reported to date.<\/jats:p>","DOI":"10.3389\/fsurg.2021.800563","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T07:25:31Z","timestamp":1643095531000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical Treatment of a Giant Pleomorphic Adenoma of the Submandibular Gland: A Case Report"],"prefix":"10.3389","volume":"8","author":[{"given":"Zehui","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aman","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1102\/1470-7330.2007.0008","article-title":"Imaging of salivary gland tumours","volume":"7","author":"Thoeny","year":"2007","journal-title":"Cancer Imaging."},{"key":"B2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/COC.0b013e3181595ae0","article-title":"Salivary gland pleomorphic adenoma","volume":"31","author":"Mendenhall","year":"2008","journal-title":"Am J Clin Oncol."},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-46915-5_3","article-title":"Pleomorphic adenoma","volume-title":"Histopathology of the Salivary Glands","author":"Hellquist","year":"2014"},{"key":"B4","article-title":"Pleomorphic adenoma","volume-title":"Pathology & Genetics of Head and Neck Tumours, World Health Organization Classification of Tumours","author":"Eveson JW","year":"2005"},{"key":"B5","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4314\/ejhs.v25i2.13","article-title":"Pleomorphic adenoma of the parotid gland: report of a case with review of literature","volume":"25","author":"Jain","year":"2015","journal-title":"Ethiopian J Health Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1177\/014556139807700812","article-title":"Giant pleomorphic adenoma of the parotid gland: case report and review of the literature","volume":"77","author":"Buenting","year":"1998","journal-title":"Ear Nose Throat J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4098","DOI":"10.1136\/bcr.04.2011.4098","article-title":"Giant presentation of pleomorphic adenoma in major salivary gland","volume":"2011","author":"Gupta","year":"2011","journal-title":"BMJ Case Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1055\/s-0032-1322530","article-title":"A giant pleomorphic adenoma of the submandibular salivary gland: a case report","volume":"5","author":"Perumal","year":"2012","journal-title":"Craniomaxillofacial Trauma Reconstruction."},{"key":"B9","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1055\/s-2007-998373","volume":"68","author":"Schultz-Coulon","year":"1989","journal-title":"Laryngo- Rhino- Otologie."},{"key":"B10","article-title":"Pleomorphic Adenoma","volume-title":"StatPearls [Internet].","author":"Bokhari","year":"2021"},{"key":"B11","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1159\/000332705","article-title":"Fine needle aspiration cytology of pleomorphic adenoma. An analysis of 212 cases","volume":"41","author":"Viguer","year":"1997","journal-title":"Acta Cytol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/dc.20951","article-title":"Pleomorphic adenoma: Cytologic variations and potential diagnostic pitfalls","volume":"37","author":"Handa","year":"2009","journal-title":"Diagnostic Cytopathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.anl.2017.09.013","article-title":"Correlation between computed tomography imaging and histopathology in pleomorphic adenoma of parotid gland","volume":"45","author":"Kim","year":"2018","journal-title":"Auris Nasus Larynx."},{"key":"B14","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.amjoto.2014.07.013","article-title":"MRI criteria for the diagnosis of pleomorphic adenoma: a validation study","volume":"35","author":"Zaghi","year":"2014","journal-title":"Am J Otolaryngol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.3174\/ajnr.A2520","article-title":"MR imaging of parotid tumors: typical lesion characteristics in MR imaging improve discrimination between benign and malignant disease","volume":"32","author":"Christe","year":"2011","journal-title":"AJNR."},{"key":"B16","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5222\/MMJ.2021.84666","article-title":"Differentiation of benign and malignant parotid gland tumors with MRI and diffusion weighted imaging","volume":"36","author":"Orhan Soylemez","year":"2021","journal-title":"Medeniyet Med J."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/bjs.6306","article-title":"Gland-preserving surgery for pleomorphic adenoma in the submandibular gland","volume":"95","author":"Roh","year":"2008","journal-title":"Br J Surg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fsurg.2018.00003","article-title":"Parotid quadrantectomy is a safe management for localized pleomorphic adenoma","volume":"5","author":"Hussein","year":"2018","journal-title":"Front Surg."},{"key":"B19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.amjoto.2012.08.002","article-title":"Radiotherapy for pleomorphic adenoma","volume":"34","author":"Wallace","year":"2013","journal-title":"Am J Otolaryngol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.canrad.2013.09.007","volume":"18","author":"Jardel","year":"2014","journal-title":"Cancer Radiotherapie."},{"key":"B21","doi-asserted-by":"publisher","first-page":"100674","DOI":"10.1016\/j.adro.2021.100674","article-title":"Radiation therapy after surgical resection improves outcomes for patients with recurrent pleomorphic adenoma","volume":"6","author":"Nicholas","year":"2021","journal-title":"Adv Radiation Oncol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1002\/lary.24964","article-title":"Etiology and management of recurrent parotid pleomorphic adenoma","volume":"125","author":"Witt","year":"2015","journal-title":"Laryngoscope."},{"key":"B23","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00405-018-5205-z","article-title":"The role of adjuvant radiotherapy in management of recurrent pleomorphic adenoma of the parotid gland: a systematic review","volume":"276","author":"Mc Loughlin","year":"2019","journal-title":"Euro Arch Oto-Rhino-Laryngol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/cjp2.216","article-title":"Malignant transformation of salivary gland pleomorphic adenoma: proof of principle","volume":"7","author":"Valstar","year":"2021","journal-title":"J Pathol Clin Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1177\/0145561319855376","article-title":"The difference in the clinical features between carcinoma ex pleomorphic adenoma and pleomorphic adenoma","volume":"98","author":"Seok","year":"2019","journal-title":"Ear Nose Throat J."}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.800563\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T07:25:35Z","timestamp":1643095535000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.800563\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,25]]},"references-count":25,"alternative-id":["10.3389\/fsurg.2021.800563"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2021.800563","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2022,1,25]]},"article-number":"800563"}}