{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:24:30Z","timestamp":1792232670881,"version":"4.4.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2020JDKP0023"],"award-info":[{"award-number":["2020JDKP0023"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Surgical treatment is usually suitable for patients with esophageal leiomyoma. Video-assisted thoracic surgery (VATS) offers a minimally invasive approach to thoracotomy. However, there is no clear conclusion on whether VATS can achieve an equal or even better surgical effect when compared with the traditional open approach in the treatment of esophageal leiomyoma. We performed this meta-analysis to explore and compare the outcomes of VATS vs. thoracotomy for patients with esophageal leiomyoma.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Medline, and Web of Science databases were searched for full-text literature citations. The quality of the articles was evaluated using the Newcastle\u2013Ottawa Scale and the data were analyzed using the Review Manager 5.3 software. Fixed or random effect models were applied according to heterogeneity.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 8 studies with 290 patients, of whom 141 patients were in the VATS group and 149 in the thoracotomy group, were involved in the analysis. Compared with thoracotomy, VATS was associated with shorter operative time, less blood loss in operation, and shorter postoperative hospital stay. There is no significant difference in postoperative pleural drainage day and postoperative complications between the two groups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> VATS has more advantages over thoracotomy, indicating that VATS is better than thoracotomy in terms of postoperative recovery. We look forward to more large-sample, high-quality studies published in the future.<\/jats:p>","DOI":"10.3389\/fsurg.2021.809253","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T04:25:35Z","timestamp":1641875135000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Video-Assisted Thoracic Surgery vs. Thoracotomy for the Treatment in Patients With Esophageal Leiomyoma: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"8","author":[{"given":"Cheng","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3906\/sag-1303-93","article-title":"Leiomyoma of the esophagus: open versus thoracoscopic enucleation","volume":"44","author":"Ziyade","year":"2014","journal-title":"Turkish J Med Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1089\/lap.2018.0412","article-title":"Video-assisted thoracoscopic surgery for esophageal leiomyoma: a ten-year single-institution experience","volume":"28","author":"Xu","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech Part A."},{"key":"B3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.4321\/S1130-01082006000500005","article-title":"Surgical treatment of esophageal leiomyoma: an analysis of our experience","volume":"98","author":"Priego","year":"2006","journal-title":"Revista espanola de enfermedades digestivas."},{"key":"B4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.5090\/kjtcs.2015.48.1.40","article-title":"Retrospective analysis of thoracoscopic surgery for esophageal submucosal tumors","volume":"48","author":"Kang","year":"2015","journal-title":"Korean J Thor Cardiovasc Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/ases.12910","article-title":"Giant circumferential esophageal leiomyoma successfully treated by thoracoscopic enucleation with the patient in a prone position: a case report","volume":"14","author":"Higuchi","year":"2021","journal-title":"Asian J Endosc Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ijscr.2020.09.142","article-title":"Leiomyoma of esophagus-A case report","volume":"76","author":"Thakut","year":"2020","journal-title":"Int J Surg Case Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e922422","DOI":"10.12659\/AJCR.922422","article-title":"A right video-assisted thoracoscopic enucleation of a calcified esophageal leiomyoma: a case report","volume":"21","author":"Alsinan","year":"2020","journal-title":"Am J Case Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/den.13453","article-title":"Thoracoscopic and endoscopic cooperative surgery for a giant esophageal leiomyoma","volume":"31","author":"Dong","year":"2019","journal-title":"Digest Endosc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.21037\/jovs.2017.03.19","article-title":"Left video-assisted thoracoscopic enucleation of a giant horseshoe oesophageal leiomyoma","volume":"3","author":"Chan","year":"2017","journal-title":"J Visual Surg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1093\/ejcts\/ezu146","article-title":"Partial oesophagectomy for giant leiomyoma of the oesophagus: report of 7 cases","volume":"47","author":"De Giacomo","year":"2015","journal-title":"Eur J Cardiothor Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e16","DOI":"10.1097\/SLE.0b013e318200e2b2","article-title":"Thoracoscopic resection of a combined esophageal leiomyoma and diverticulum: a case report","volume":"21","author":"Koplin","year":"2011","journal-title":"Surg Laparosc Endosc Percutaneous Tech."},{"key":"B12","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1111\/j.1442-2050.2008.00917.x","article-title":"Minimally invasive surgical enucleation for esophageal leiomyoma: report of seven cases","volume":"23","author":"Obuchi","year":"2010","journal-title":"Dis Esophagus."},{"key":"B13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.17235\/reed.2015.3845\/2015","article-title":"Comparative study between open and minimally invasive approach in the surgical management of esophageal leiomyoma","volume":"108","author":"Ramos","year":"2016","journal-title":"Revista espanola de enfermedades digestivas."},{"key":"B14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.5606\/tgkdc.dergisi.2020.18889","article-title":"Clinical outcomes in the surgical treatment of esophageal leiomyoma: a retrospective evaluation of 13 cases","volume":"28","author":"Yal\u00e7inkaya","year":"2020","journal-title":"Turk gogus kalp damar cerrahisi dergisi."},{"key":"B15","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.athoracsur.2013.10.030","article-title":"Enucleation of esophageal submucosal tumors: a single institution's experience","volume":"97","author":"Shin","year":"2014","journal-title":"Ann Thor Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1007\/s00464-003-9130-9","article-title":"Enucleation of submucosal tumors of the esophagus: minimally invasive versus open approach","volume":"18","author":"von Rahden","year":"2004","journal-title":"Surg Endosc."},{"key":"B17","first-page":"17214","article-title":"Diagnosis and comprehensive treatment of esophageal leiomyoma: clinical analysis of 77 patients","volume":"8","author":"Wang","year":"2015","journal-title":"Int J Clin Exp Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ijscr.2017.03.007","article-title":"Thoracoscopic enucleation in the left decubitus position for leiomyoma of the upper thoracic esophagus: utility of preoperative diagnosis applying endoscopic ultrasound-guided fine needle aspiration","volume":"34","author":"Ishii","year":"2017","journal-title":"Int J Surg Case Rep."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1111\/dote.12441","article-title":"Novel methylene blue staining technique for localizing small esophageal leiomyomas during thoracoscopic enucleation","volume":"29","author":"Zhang","year":"2016","journal-title":"Dis Esophagus."},{"key":"B20","doi-asserted-by":"publisher","first-page":"7453259","DOI":"10.1155\/2016\/7453259","article-title":"Video assisted thoracoscopic surgical enucleation of a giant esophageal leiomyoma presenting with persistent cough","volume":"2016","author":"Mujawar","year":"2016","journal-title":"Case Rep Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"bcr2016216837","DOI":"10.1136\/bcr-2016-216837","article-title":"Giant oesophageal leiomyoma causing severe hypertension","volume":"2016","author":"Lovece","year":"2016","journal-title":"BMJ Case Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/dote.12220","article-title":"Intraoperative esophagoscopy provides accuracy and safety in video-assisted thoracoscopic enucleation of benign esophageal submucosal tumors","volume":"28","author":"Jeon","year":"2015","journal-title":"Dis Esophagus."},{"key":"B23","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.suc.2015.02.005","article-title":"Benign esophageal tumors","volume":"95","author":"Ha","year":"2015","journal-title":"Surg Clin North Am."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.gie.2015.11.008","article-title":"Successful resection of large esophageal leiomyoma by a combined thoracoscopic-endoscopic submucosal tunneling method","volume":"83","author":"Kanetaka","year":"2016","journal-title":"Gastroint Endoscopy."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11748-021-01717-y","article-title":"Effectiveness and safety of a newly introduced multidisciplinary perioperative enhanced recovery after surgery protocol for thoracic esophageal cancer surgery","volume":"1","author":"Sato","year":"2021","journal-title":"Gen Thor Cardiovasc Surg."},{"key":"B26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00595-020-01956-1","article-title":"The enhanced recovery after surgery (ERAS) protocol to promote recovery following esophageal cancer resection","volume":"50","author":"Ashok","year":"2020","journal-title":"Surg Today."},{"key":"B27","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bone.2018.05.013","article-title":"Observation of clinical efficacy of application of enhanced recovery after surgery in perioperative period on esophageal carcinoma patients","volume":"23","author":"Zhang","year":"2018","journal-title":"J BUON."},{"key":"B28","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1186\/s12885-017-3831-2","article-title":"Prediction of postoperative inflammatory complications after esophageal cancer surgery based on early changes in the C-reactive protein level in patients who received perioperative steroid therapy and enhanced recovery after surgery care: a retrospective analysis","volume":"17","author":"Kano","year":"2017","journal-title":"BMC Cancer."},{"key":"B29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s13304-020-00963-8","article-title":"Application of ERAS protocol in esophagectomy: a national survey among Italian centers performing esophageal surgery","volume":"73","author":"Parise","year":"2021","journal-title":"Updates Surg."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/dox074","article-title":"Association of high-dose postoperative opioids with recurrence risk in esophageal squamous cell carcinoma: reinterpreting ERAS protocols for long-term oncologic surgery outcomes","volume":"30","author":"Oh","year":"2017","journal-title":"Dis Esophagus."},{"key":"B31","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/dote.12214","article-title":"Enhanced recovery pathways lead to an improvement in postoperative outcomes following esophagectomy: systematic review and pooled analysis","volume":"28","author":"Markar","year":"2015","journal-title":"Dis Esophagus."}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.809253\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T04:25:38Z","timestamp":1641875138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.809253\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,11]]},"references-count":31,"alternative-id":["10.3389\/fsurg.2021.809253"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2021.809253","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,11]]},"article-number":"809253"}}