{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:33:59Z","timestamp":1753893239471,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770537"],"award-info":[{"award-number":["31770537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Hepatocellular carcinoma (HCC), combined with hepatic hydatid disease, is a rare clinical case, having certain specificity in clinical diagnosis and treatment. We report a case of HCC combined with hepatic hydatid disease treated in our clinic to arouse the attention of clinicians to the disease. A 54-year-old female patient was admitted to the clinic on October 31, 2016 because of \u201cIntermittent upper abdominal pain and discomfort for 1 month.\u201d Abdominal CT in the previous hospital showed liver space-occupying lesions, and hepatic hydatid disease should be considered. The patient had a history of hepatitis B virus (HBV) infection since childhood but has not received antiviral treatment. She did have a history of life in pastoral areas. Laboratory examination results were as follows: alpha-fetoprotein (AFP) 1,210 ng\/ml, HBV DNA: 5.32E + 3 IU\/ml. Casoni test was positive. Enhanced CT of abdomen suggestion was: malignant liver tumor, hepatic hydatid disease. Gastroscopy and colonoscopy showed no abnormalities. She underwent an operation on November 10, 2016. Segment 5, 8 of hepatic, echinococcus internal capsule, and cholecyst were all removed. She took albendazole (0.4 g\/day) for 6 months and oral entecavir (0.5 mg\/day) antiviral treatment for a long time after surgery. From May 2017 to October 2019, a total of 5 cycles of transarterial chemotherapy embolization (TACE) were performed. The patient underwent surgical treatment, followed by TACE, antiviral therapy, and sequential albendazole treatment. The AFP level increased significantly, but there was no obvious recurrence of HCC in imaging.<\/jats:p>","DOI":"10.3389\/fsurg.2021.816501","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T04:45:25Z","timestamp":1643777125000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hepatocellular Carcinoma Complicated by Echinococcal Cyst: A Case Report"],"prefix":"10.3389","volume":"8","author":[{"given":"Jiwu","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenzhe","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Futian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s12072-020-10085-3","article-title":"Effect of HBV-HDV co-infection on HBV-HCC co-recurrence in patients undergoing living donor liver transplantation","volume":"14","author":"Baskiran","year":"2020","journal-title":"HepatolInt."},{"key":"B2","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/s41575-019-0186-y","article-title":"global view of hepatocellular carcinoma: trends, risk, prevention and management","volume":"16","author":"Yang","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1128\/JCM.02420-15","article-title":"Cystic echinococcosis","volume":"54","author":"Agudelo Higuita","year":"2016","journal-title":"J Clin Microbiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1056\/NEJMra1713263","article-title":"Hepatocellular carcinoma","volume":"380","author":"Villanueva","year":"2019","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4240\/wjgs.v6.i10.190","article-title":"Hydatid cyst of the pancreas: report of an undiagnosed case of pancreatic hydatid cyst and brief literature review","volume":"6","author":"Akbulut","year":"2014","journal-title":"World J Gastrointest Surg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"789","DOI":"10.14744\/tjtes.2020.32223","article-title":"Intraperitoneal rupture of the hydatid cyst disease: Single-center experience and literature review","volume":"26","author":"Koc","year":"2020","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e10671","DOI":"10.1097\/MD.0000000000010671","article-title":"Parietal complication of the hydatid disease: comprehensive literature review","volume":"97","author":"Akbulut","year":"2018","journal-title":"Medicine."},{"key":"B8","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/bs.apar.2016.11.001","article-title":"Global distribution of alveolar and cystic echinococcosis","volume":"95","author":"Deplazes","year":"2017","journal-title":"Adv Parasitol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.asjsur.2021.03.004","article-title":"Comment on Operative treatment of hepatic hydatid cysts: a single center experience","volume":"44","author":"Akbulut","year":"2021","journal-title":"Asian J Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.9738\/INTSURG-D-14-00068.1","article-title":"Role of chemotherapeutic agents in the management of cystic echinococcosis","volume":"100","author":"Nazligul","year":"2015","journal-title":"Int Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"659","DOI":"10.12998\/wjcc.v9.i3.659","article-title":"Radical resection of hepatic polycystic echinococcosis complicated with hepatocellular carcinoma: a case report","volume":"9","author":"Kalifu","year":"2021","journal-title":"World J Clin Cases."},{"key":"B12","first-page":"297","article-title":"A synchronous occurrence of hepatocellular carcinoma and echinoccocal liver cyst - can parasite promote carcinogenesis? 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