{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:39:05Z","timestamp":1776119945046,"version":"3.50.1"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the risk factors of acute respiratory distress syndrome (ARDS) secondary to thoracic trauma and the therapeutic effect of protective lung ventilation in patients with acute respiratory distress syndrome complicated with thoracic trauma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected 206 patients with thoracic trauma admitted to our hospital from September 2017 to March 2021, counted the incidence of ARDS and analyzed the risk factors of ARDS. To observe the clinical efficacy of the application of lung-protective ventilation therapy in patients with thoracic trauma combined with ARDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 206 patients with thoracic trauma, there were 82 cases of combined ARDS, and its incidence was 39.81%. The 82 patients with ARDS were randomly divided into the control group and the observation group with 42 cases each, and different ventilation methods were used for treatment. The results showed that the mechanical ventilation time (MVT) was shorter in the observation group than in the control group, and the incidence of ventilator-associated lung injury (VALI) and case fatality rate (CFR) were lower than those in the control group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Arterial partial pressure of oxygen (Pa0<jats:sub>2<\/jats:sub>), arterial blood carbon dioxide partial pressure (PaCO<jats:sub>2<\/jats:sub>), and Oxygenation index (arterial partial pressure of oxygen\/Fraction of inspiration O<jats:sub>2<\/jats:sub>, PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>) were significantly improved better in both groups after treatment; compared with the control group, patients in the observation group had higher Pa02 levels and lower PaCO<jats:sub>2<\/jats:sub> levels at 8 h and 24 h after ventilation (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Multivariate analysis revealed that blunt trauma, massive blood transfusion, procalcitonin (PCT) level, tumor necrosis factor-\u03b1 (TNF-\u03b1) level, and acute physiology and chronic health score (APACHE II) were all risk factors for Thoracic trauma with ARDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Risk factors for the development of ARDS after thoracic trauma are blunt injuries, massive blood transfusion, high PCT and TNF-\u03b1 levels, and high APACHE II scores, which can be given active interventions in the early stage of clinical practice to improve patient prognosis. The use of protective lung ventilation therapy can improve the clinical outcome of patients with thoracic trauma combined with ARDS, which is important for improving the ventilation effect and respiratory function of patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2021.826682","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T05:19:41Z","timestamp":1643001581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk Factors Analysis of Thoracic Trauma Complicated With Acute Respiratory Distress Syndrome and Observation of Curative Effect of Lung-Protective Ventilation"],"prefix":"10.3389","volume":"8","author":[{"given":"Xiaoyu","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zefang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peidong","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaolin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neubiorev.2020.10.020","article-title":"An update on the association between traumatic brain injury and Alzheimer's disease: focus on tau pathology and synaptic dysfunction","volume":"120","author":"Li","year":"2021","journal-title":"Neurosci Biobehav Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.cjtee.2020.04.003","article-title":"Blunt trauma related chest wall and pulmonary injuries: an overview","volume":"23","author":"Dogrul","year":"2020","journal-title":"Chin J Traumatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1056\/NEJMra1608077","article-title":"Acute Respiratory Distress Syndrome","volume":"377","author":"Thompson","year":"2017","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s13054-020-2777-y","article-title":"Monitoring patient respiratory effort during mechanical ventilation: lung and diaphragm-protective ventilation","volume":"24","author":"Bertoni","year":"2020","journal-title":"Crit Care."},{"key":"B5","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1164\/rccm.201907-1283CI","article-title":"Mechanical ventilation for acute respiratory distress syndrome during extracorporeal life support","volume":"201","author":"Abrams","year":"2020","journal-title":"Res Pract Am J Respir Crit Care Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1186\/s13054-016-1556-2","article-title":"investigators of the Acurasys and Proseva trials. Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials","volume":"20","author":"Gu\u00e9rin","year":"2016","journal-title":"Crit Care."},{"key":"B7","doi-asserted-by":"publisher","first-page":"k3030","DOI":"10.1136\/bmj.k3030","article-title":"Perioperative lung protective ventilation","volume":"362","author":"O'Gara","year":"2018","journal-title":"BMJ."},{"key":"B8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.accpm.2019.04.006","article-title":"in patients with chest trauma: better safe than sorry","volume":"38","author":"Jabaudon","year":"2019","journal-title":"Anaesth Crit Care Pain Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.jpedsurg.2018.07.005","article-title":"Pediatric trauma-associated acute respiratory distress syndrome: Incidence, risk factors, and outcomes","volume":"54","author":"de Roulet","year":"2019","journal-title":"J Pediatr Surg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care","volume":"14","author":"Baker","year":"1974","journal-title":"J Trauma."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1001\/jama.2012.5669","article-title":"Acute respiratory distress syndrome: the Berlin Definition","volume":"307","author":"ARDS Definition Task","year":"2012","journal-title":"JAMA."},{"key":"B12","doi-asserted-by":"publisher","first-page":"837513","DOI":"10.1155\/2012\/837513","article-title":"Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats","volume":"2012","author":"Fu","year":"2012","journal-title":"Evid Based Complement Alternat Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.accpm.2018.09.009","article-title":"Acute respiratory distress syndrome after chest trauma: Epidemiology, specific physiopathology and ventilation strategies","volume":"38","author":"Ramin","year":"2019","journal-title":"Anaesth Crit Care Pain Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.21873\/invivo.11634","article-title":"Impact of accidental hypothermia on pulmonary complications in multiply injured patients with blunt chest trauma\u2014a matched-pair analysis","volume":"33","author":"Winkelmann","year":"2019","journal-title":"In Vivo."},{"key":"B15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.injury.2015.08.031","article-title":"Thoracic Trauma Severity score on admission allows to determine the risk of delayed ARDS in trauma patients with pulmonary contusion","volume":"47","author":"Daurat","year":"2016","journal-title":"Injury."},{"key":"B16","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jss.2011.09.018","article-title":"Comparison of different thoracic trauma scoring systems in regards to prediction of post-traumatic complications and outcome in blunt chest trauma","volume":"176","author":"Mommsen","year":"2012","journal-title":"J Surg Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.chest.2020.05.603","article-title":"Cigarette smoking and ARDS after blunt trauma: the influence of changing smoking patterns and resuscitation practices","volume":"158","author":"Moazed","year":"2020","journal-title":"Chest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"e0159417","DOI":"10.1371\/journal.pone.0159417","article-title":"Role of complement C5 in experimental blunt chest trauma-induced septic acute lung injury (ALI)","volume":"11","author":"Kalbitz","year":"2016","journal-title":"PLoS ONE."},{"key":"B19","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1097\/SHK.0000000000001073","article-title":"PROPPR Study Group. Risk factors for the development of acute respiratory distress syndrome following hemorrhage","volume":"50","author":"Robinson","year":"2018","journal-title":"Shock."},{"key":"B20","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jcrc.2005.12.012","article-title":"GITAN multicenter project. Early markers of acute respiratory distress syndrome development in severe trauma patients","volume":"21","author":"Navarrete-Navarro","year":"2006","journal-title":"J Crit Care."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1097\/CCM.0b013e3182544f6a","article-title":"Acute respiratory distress syndrome after trauma: development and validation of a predictive model","volume":"40","author":"Watkins","year":"2012","journal-title":"Crit Care Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s40001-015-0164-y","article-title":"The molecular fingerprint of lung inflammation after blunt chest trauma","volume":"20","author":"Ehrnthaller","year":"2015","journal-title":"Eur J Med Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.3892\/etm.2016.3355","article-title":"Clinical study on VATS combined mechanical ventilation treatment of ARDS secondary to severe chest trauma","volume":"12","author":"Qi","year":"2016","journal-title":"Exp Ther Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.4187\/respcare.07876","article-title":"Comparing the effects of tidal volume, driving pressure, and mechanical power on mortality in trials of lung-protective mechanical ventilation","volume":"66","author":"Dianti","year":"2021","journal-title":"Respir Care."}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.826682\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T05:19:44Z","timestamp":1643001584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2021.826682\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":24,"alternative-id":["10.3389\/fsurg.2021.826682"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2021.826682","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]},"article-number":"826682"}}