{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:02:32Z","timestamp":1768816952436,"version":"3.49.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971578, 81901791"],"award-info":[{"award-number":["81971578, 81901791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Castleman's disease (CD) is a rare benign lymphoproliferative disease that frequently involves the mediastinal thorax and the neck lymph nodes. It rarely affects extrathoracic presentations, with even fewer presentations in the renal sinus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient concerns<\/jats:title><jats:p>In this report, we present a case of a 40-year-old woman with no significant past medical history who presented Castleman's disease arising in the renal sinus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Diagnosis and interventions<\/jats:title><jats:p>The patient visited our hospital with the chief complaint of left renal sinus lesion after renal ultrasonography by regular physical examination. Subsequent abdominal computed tomography urography revealed a soft tissue mass with heterogeneous obvious enhancement in the sinus of the left kidney, which was suspected to be a renal malignant tumor. Hence, the patient underwent a left radical nephrectomy. Histological examination revealed hyperplastic lymphoid follicles in the renal sinus and was finally diagnosed as Castleman's disease of the hyaline vascular type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcomes<\/jats:title><jats:p>Five days after the surgery procedure, the patient was discharged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Due to the low incidence of Castleman's disease in renal sinus, there is a strong likelihood of missed diagnosis or misdiagnosis, and it is, therefore, important to be aware of the risk. Heightened awareness of this disease and its radiographic manifestations may prompt consideration of this diagnosis. Therefore, we explored the radiologic findings to find out some radiologic features suggesting this condition to help clinicians to schedule nephron-sparing surgery in the future.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.1001350","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T05:43:13Z","timestamp":1662356593000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case report: Castleman\u2019s disease involving the renal sinus resembling renal cell carcinoma"],"prefix":"10.3389","volume":"9","author":[{"given":"Enlong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.hoc.2017.09.005","article-title":"Diagnosis of Castleman disease","volume":"32","author":"Szalat","year":"2018","journal-title":"Hematol Oncol Clin North Am"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hoc.2017.09.001","article-title":"Epidemiology of Castleman disease","volume":"32","author":"Simpson","year":"2018","journal-title":"Hematol Oncol Clin North 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99mTc DTPA renal scintigraphy","volume":"37","author":"Song","year":"2012","journal-title":"Clin Nucl Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"6039","DOI":"10.1182\/bloodadvances.2020003334","article-title":"International evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman disease","volume":"4","author":"van Rhee","year":"2020","journal-title":"Blood Adv"},{"key":"B8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1089\/cren.2015.0015","article-title":"Castleman disease presenting as renal hilar mass","volume":"1","author":"Radfar","year":"2015","journal-title":"J Endourol Case Rep"},{"key":"B9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF02926563","article-title":"Castleman\u2019s disease with vascular encasement and renal sinus involvement","volume":"10","author":"Nolan","year":"1988","journal-title":"Urol Radiol"},{"key":"B10","first-page":"95","article-title":"Multicentric Castleman\u2019s disease found by a renal sinus lesion: a case report","volume":"46","author":"Nagahama","year":"2000","journal-title":"Hinyokika Kiyo"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.2214\/ajr.181.4.1811037","article-title":"Radiologic features of Castleman\u2019s disease occupying the renal sinus","volume":"181","author":"Nishie","year":"2003","journal-title":"Am J Roentgenol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3904\/kjim.2007.22.2.113","article-title":"Castleman disease presenting with jaundice: a case with the multicentric hyaline vascular variant","volume":"22","author":"Park","year":"2007","journal-title":"Korean J Intern Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"658","DOI":"10.3348\/kjr.2012.13.5.658","article-title":"Plasma cell type of Castleman\u2019s disease involving renal parenchyma and sinus with cardiac tamponade: case report and literature 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