{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:29:11Z","timestamp":1787027351242,"version":"build-2736575974"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY20H020003"],"award-info":[{"award-number":["LY20H020003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ20H020004"],"award-info":[{"award-number":["LQ20H020004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial septal defect is one of the most common congenital heart diseases in adults. Primum atrial septal defect (PASD) accounts for 4%\u20135% of congenital heart defects. Patients with PASD frequently suffer mitral insufficiency (MI), and thus, mitral valvuloplasty (MVP) or mitral valve replacement (MVR) is often required at the time of PASD repair. Unfortunately, recurrent unrepairable severe mitral regurgitation can develop in many patients undergoing PASD repair plus MVP in either short- or long-term after the repair surgery, requiring a re-do MVR. In those patients, the risk of left ventricular outflow tract obstruction (LVOTO) has increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We present five such cases, ranging in age from 24 to 47 years, who had a PASD repair plus MVP or MVR for 14\u201340 years while suffering moderate to severe mitral regurgitation. Using Medtronic AP360 mechanical mitral prostheses, only one patient experienced mild LVOTO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of Medtronic AP360 mechanical mitral prostheses to perform MVR in patients with MI who had a history of PASD repair can potentially reduce the risk of LVOTO. Long-term follow-up is required to further confirm this clinical benefit associated with AP360 implantation in patients with PASD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2022.1008444","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T01:10:40Z","timestamp":1672967440000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Using Medtronic AP360 mechanical prosthesis in mitral valve replacement for patients with mitral insufficiency after primum atrial septal defect repair to reduce left ventricular outflow tract obstruction risk"],"prefix":"10.3389","volume":"9","author":[{"given":"Lei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haige","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.jpeds.2008.05.059","article-title":"Prevalence of congenital heart defects in metropolitan Atlanta, 1998\u20132005","volume":"153","author":"Reller","year":"2008","journal-title":"J Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1053\/j.semtcvs.2020.08.009","article-title":"Repair of partial atrioventricular septal defects in adults: a single center experience","volume":"33","author":"Patlolla","year":"2021","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"B4","first-page":"1352","volume-title":"Ann Thorac Surg","author":"Stulak","year":"2010"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0003-4975(99)01074-7","article-title":"Left ventricular outflow tract obstruction after partial atrioventricular septal defect repair","volume":"68","author":"Gurbuz","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1053\/j.pcsu.2014.01.008","article-title":"Reoperation for left ventricular outflow tract obstruction after repair of atrioventricular septal","volume":"17","author":"Overman","year":"2014","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"B7","doi-asserted-by":"publisher","first-page":"rjy357","DOI":"10.1093\/jscr\/rjy357","article-title":"A novel case of late left ventricular outflow tract obstruction post mitral valve surgery","volume":"2019","author":"Jones","year":"2019","journal-title":"J Surg Case Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/clc.4960140611","article-title":"Left ventricular outflow tract obstruction in atrioventricular septal defects: a pathologic and morphometric evaluation","volume":"14","author":"Gallo","year":"1991","journal-title":"Clin Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/jocs.12749","article-title":"Acute LVOT obstruction with a carbomedics mechanical valve prosthesis","volume":"31","author":"Alsidawi","year":"2016","journal-title":"J Card Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s13019-018-0788-4","article-title":"Prosthesis-patient mismatch after mitral valve replacement: a single-centered retrospective analysis in East China","volume":"13","author":"Akuffu","year":"2018","journal-title":"J Cardiothorac Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1016\/j.athoracsur.2013.04.092","article-title":"Chimney technique for mitral valve replacement in children","volume":"96","author":"Gonzalez","year":"2013","journal-title":"Ann Thorac Surg"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.1008444\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T01:10:43Z","timestamp":1672967443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.1008444\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":11,"alternative-id":["10.3389\/fsurg.2022.1008444"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.1008444","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,6]]},"article-number":"1008444"}}