{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:34:24Z","timestamp":1753893264968,"version":"3.41.2"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-027"],"award-info":[{"award-number":["2021-I2M-1-027"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Frozen elephant trunk technique (FET) has been proven to provide an excellent landing zone for second-stage thoracoabdominal (TA) aortic repair. The aim of this study was to evaluate the impact of FET in TA aortic repair with normothermic iliac perfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2008 to December 2019, 144 patients undergoing TA repair with normothermic iliac perfusion were enrolled in this study. Early and mid-term outcomes of patients with previous FET implantation (group A, <jats:italic>n<\/jats:italic>\u2009=\u200962) were compared with patients without previous FET implantation (group B, <jats:italic>n<\/jats:italic>\u2009=\u200982). The logistic regression analysis was performed to investigate the risk factors for adverse events, which were de\ufb01ned as early death, permanent stroke, permanent paraplegia, or permanent renal failure necessitating dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proximal aortic clamp time and operating time was 14.26\u2009\u00b1\u20095.57\u2005min and 357.40\u2009\u00b1\u200994.51 respectively in group A, which were both significantly shorter than that in group B (18.67\u2009\u00b1\u20095.24\u2005min and 18.67\u2009\u00b1\u20095.24\u2005min). The incidence of adverse event was significantly lower in group A than that in group B (9.7% vs. 25.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.027). There was no significant difference between two groups with regard to other complications or late outcomes. In addition, age &amp;gt;50 years, a Ccr\u2009&amp;lt;\u200990\u2005ml\/min\/1.73\u2005m<jats:sup>2<\/jats:sup> and the operating time were identified as significant risk factors through logistic regression analysis for adverse events of TA repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FET technique simplifies the operative technique of proximal anastomosis, decreases the operating time and improves the early outcomes in TA repair, whereas does not provide a significant benefit with regard to late outcomes. Long-term follow-up and studies with larger sample sizes are necessary for further confirmation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.1044089","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T07:43:16Z","timestamp":1672990996000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of frozen elephant trunk on the outcomes of thoracoabdominal aortic repair with normothermic iliac 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