{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:02:30Z","timestamp":1791597750101,"version":"4.3.4"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971275"],"award-info":[{"award-number":["31971275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Drug fever is a febrile reaction that emerges temporarily with the administration of a drug or a variety of drugs and disappears after cessation of the targeting agent. There are a few previous reports about drug fever, but they pertain mainly to patients accompanied by no surgical intervention. Based on the literature reviewed, drug fever in patients after posterior cervical spine surgery has never been mentioned before; therefore, we present a 56-year-old man diagnosed with drug fever after posterior cervical spine surgery for traumatic cervical myelopathy. Fortunately, his body temperature rapidly came down in 2\u00a0days after discontinuing the antibiotics. He was discharged after two more days of observation, and the patient recovered well without any further complaints. Early diagnosis of drug fever may greatly reduce inappropriate and potentially detrimental diagnostic and therapeutic interventions. For patients with persistent fever, if it happened days after surgery, particularly when it is without any infectious evidence, then it is necessarily important to consider a possible reason of drug-induced fever.<\/jats:p>","DOI":"10.3389\/fsurg.2022.1065106","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T05:33:45Z","timestamp":1673415225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Drug fever induced by antibiotics of \u03b2-lactams in a patient after posterior cervical spine surgery\u2014A case report and literature review"],"prefix":"10.3389","volume":"9","author":[{"given":"Yunxiang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanmao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1093\/jbcr\/irz064","article-title":"Heparin-induced fever: a case report and literature review","volume":"40","author":"Laun","year":"2019","journal-title":"J Burn Care Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/jcpt.13490","article-title":"Celecoxib-induced drug fever: a rare case report and literature review","volume":"47","author":"Xiao","year":"2022","journal-title":"J Clin Pharm Ther"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1001\/archinte.1991.00400090141026","article-title":"Drug-induced fever due to diltiazem","volume":"151","author":"Dominguez","year":"1991","journal-title":"Arch Intern Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"209","DOI":"10.7326\/0003-4819-85-2-209","article-title":"Letter: fever from ibuprofen in a patient with lupus erythematosus","volume":"85","author":"Mandell","year":"1976","journal-title":"Ann Intern Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.2169\/internalmedicine.5394-20","article-title":"A favipiravir-induced fever in a patient with COVID-19","volume":"59","author":"Kurita","year":"2020","journal-title":"Intern Med"},{"key":"B6","doi-asserted-by":"publisher","year":"","DOI":"10.1097\/00124743-199702000-00016"},{"key":"B7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0160-3450(15)30635-8","article-title":"Understanding drug-induced febrile reactions: when a fever of unknown etiology develops it is important to consider drug fever to avoid delays additional costs of treatment","volume":"33","author":"Roush","year":"1993","journal-title":"Am Pharm"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-5-728","article-title":"Drug fever: a critical appraisal of conventional concepts. 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