{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:58Z","timestamp":1787679058029,"version":"build-2784847793"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Cryptococcus<\/jats:italic>, a kind of fungus, can be found in soil, decayed wood, and avian excreta. Immunocompromised patients are prone to infection caused by <jats:italic>Cryptococcus<\/jats:italic>, and the lungs and central nervous system are the main target organs. Cryptococcosis rarely occurs in the lumbar vertebra or in immunocompetent patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 40-year-old adult male with isolated lumbar vertebra cryptococcosis at the L4 vertebra underwent successful lesion removal surgery performed <jats:italic>via<\/jats:italic> the posterior approach and postoperative administration of an antifungal agent. At the 12-month follow-up, the patient's pain was relieved, and his motor function had improved. Isolated <jats:italic>Cryptococcus<\/jats:italic> vertebrae infection is a rare infectious disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A needle biopsy can confirm the diagnosis of <jats:italic>Cryptococcus<\/jats:italic> infection. When patients present with unbearable symptoms of nerve compression, posterior depuration combined with postoperative antifungal agents is a good option.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.1079732","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T12:38:48Z","timestamp":1673008728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Isolated cryptococcosis of a\u00a0lumbar vertebra in an immunocompetent patient: A\u00a0case report and literature review"],"prefix":"10.3389","volume":"9","author":[{"given":"Zhongxiong","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0012-3692(15)31671-8","article-title":"Pulmonary cryptococcosis in nonimmunocompromised patients","volume":"124","author":"Nadrous","year":"2003","journal-title":"Chest"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2007.apm_513.x","article-title":"Cryptococcosis\u2014a review of 13 autopsy cases from a 54-year period in a large hospital","volume":"115","author":"Benesov\u00e5","year":"2010","journal-title":"APMIS"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.5.837","article-title":"Cryptococcal meningitis and AIDS","author":"Powderly","year":"","journal-title":"Clin Infect Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1513\/pats.200907-063AL","article-title":"Cryptococcus","volume":"7","author":"Li","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1093\/qjmed\/hcl014","article-title":"Cryptococcosis in apparently immunocompetent patients","volume":"99","author":"Lui","year":"2006","journal-title":"QJM"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.2.181","article-title":"Cryptococcal skeletal infections: case report and review","author":"Behrman","year":"1990","journal-title":"Rev Infect Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1227\/00006123-199306000-00028","article-title":"Cryptococcal skull infection: a case report with review of the literature","volume":"32","author":"Armonda","year":"1993","journal-title":"Neurosurgery"},{"key":"B8","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/BF00266342","article-title":"Skeletal cryptococcosis","volume":"59","author":"Chleboun","year":"1977","journal-title":"J Bone Jt Surg"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2013.11.003","article-title":"Cryptococcose extra-neurom\u00e9ning\u00e9e au cours du sida \u00e0 Bamako, Mali (\u00e0\u00a0propos de 2 observations)","volume":"24","author":"Minta","year":"2014","journal-title":"J Mycol M\u00e9d"},{"key":"B10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.25259\/SNI-49-2019","article-title":"Thoracic cryptococcal osteomyelitis mimicking tuberculosis: a case report","volume":"10","author":"Adsul","year":"2019","journal-title":"Surg Neurol Int"},{"key":"B11","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s15010-007-6109-9","article-title":"Cryptococcus neoformans abscess and osteomyelitis in an immunocompetent patient with tuberculous lymphadenitis","volume":"35","author":"Al-Tawfiq","year":"2007","journal-title":"Infection"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1093\/rheumatology\/33.11.1085","article-title":"Cryptococcal spondylitis: solitary infective bone lesions are not always tuberculous","volume":"33","author":"Glynn","year":"1994","journal-title":"Br J Rheumatol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"782","DOI":"10.10520\/AJA20785135_7950","article-title":"Cryptococcal infection of the spine. 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