{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:04:26Z","timestamp":1789542266919,"version":"build-2803163510"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pathological spine fractures caused by metastases of lung cancer have brought great suffering to patients. Percutaneous kyphoplasty (PKP) has been considered a preferred alternative for painful spinal metastases. The clinical efficacy and safety of PKP for metastatic spinal lesions are urgently to be evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort study was conducted on 54 cases with pathologic spine fractures caused by metastasis of lung cancer. The correction of kyphosis was assessed by the Cobb angle. The life dependence and quality of the patients were evaluated by the Barthel Index of activities of daily living (ADL) and the quality-adjusted life year (QALY). Patients' survival was carefully recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PKP significantly corrected the kyphosis compared with conservative treatment. The ratio of moderate dependence after fracture was clearly increased by PKP. QALY indicated a better life quality brought by PKP. However, PKP could not improve the survival rate of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PKP can be used as an effective palliative care treatment for patients with metastatic pathologic spinal fractures of lung cancer.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.1081823","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T05:32:53Z","timestamp":1673933573000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Balloon kyphoplasty as palliative care for painful pathological spinal fracture followed by lung cancer metastasis: A cohort study"],"prefix":"10.3389","volume":"9","author":[{"given":"Jun-xin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-run","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI157917","article-title":"IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer","volume":"132","author":"He","year":"2022","journal-title":"J Clin Invest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0181564","DOI":"10.1371\/journal.pone.0181564","article-title":"Potential paraneoplastic syndromes and selected autoimmune conditions in patients with non-small cell lung cancer and small cell lung cancer: a population-based cohort study","volume":"12","author":"Miret","year":"2017","journal-title":"PLoS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ijsu.2016.02.031","article-title":"Clinical evaluation of percutaneous kyphoplasty in the treatment of osteolytic and osteoblastic metastatic vertebral lesions","volume":"30","author":"Wang","year":"2016","journal-title":"Int J Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.2169\/internalmedicine.0074-17","article-title":"Severe hyperkyphosis","volume":"57","author":"Shimizu","year":"2018","journal-title":"Intern Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.wneu.2017.08.130","article-title":"Prognostic factors and comparison of conservative treatment, percutaneous vertebroplasty, and open surgery in the treatment of spinal metastases from lung cancer","volume":"108","author":"Yang","year":"2017","journal-title":"World Neurosurg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1016\/j.ijsp.2013.03.001","article-title":"Kyphoplasty versus vertebroplasty for painful osteoporotic vertebral compression fractures-which one is better? 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