{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:55:26Z","timestamp":1785412526695,"version":"3.56.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to determine the efficacy and safety of celecoxib for pain management after total knee arthroplasty (TKA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched to identify eligible randomized controlled trials (RCTs) that compared celecoxib with a placebo in term of pain control efficacy after TKA. Primary outcomes included pain scores at 24, 48, and 72 h after TKA. Secondary outcomes included the active range of motion (ROM) at 24, 48,72 h, and 7 days postoperatively, morphine consumption over 72 h after TKA, incidence of postoperative nausea and vomiting (PONV), and total blood loss after surgery. Data analysis was conducted using RevMan version 5.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five RCTs involving 593 participants were included in the study. Compared with a placebo, celecoxib significantly reduced visual analog scale (VAS) scores at rest at 24 h [mean difference (MD) = \u22120.72; 95% confidence interval (CI), \u22121.27 to \u22120.17; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 82%; <jats:italic>P<\/jats:italic> = 0.01], 48 h (MD = \u22121.51; 95% CI, \u22122.07 to \u22120.95; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%; <jats:italic>P<\/jats:italic> &amp;lt; 0.00001), and 72 h (MD = \u22121.30; 95% CI, \u22122.07 to \u22120.54; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 82%; <jats:italic>P<\/jats:italic> = 0.0009) after TKA, decreased morphine consumption over postoperative 72 h (MD = \u22120.73; 95% CI, \u22120.96 to \u22120.51; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 96%; <jats:italic>P<\/jats:italic> &amp;lt; 0.00001), and increased active ROM at 48 h (MD = 13.23; 95% CI, 7.79 to 18.67; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%; <jats:italic>P<\/jats:italic> &amp;lt; 0.00001), 72 h (MD = 6.52; 95% CI, 4.95 to 8.10; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 68%; <jats:italic>P<\/jats:italic> &amp;lt; 0.00001), and 7 days (MD = 7.98; 95% CI, 3.64 to 12.31; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 68%; <jats:italic>P<\/jats:italic> = 0.0003) after the operation. No significant difference was found in the active ROM at 24 h (MD = 7.60; 95% CI, \u22126.14 to 21.34; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 94%; <jats:italic>P<\/jats:italic> = 0.28) and the incidence of PONV after surgery [risk ratio (RR) = 0.66; 95% CI, 0.40 to 1.09; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%; <jats:italic>P<\/jats:italic> = 0.11].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The administration of celecoxib is an effective and safe strategy for postoperative analgesia after TKA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.791513","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T05:28:08Z","timestamp":1643347688000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["The Efficacy and Safety of Celecoxib for Pain Management After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of 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