{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:58:16Z","timestamp":1756573096253,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Clostridial gas gangrene is an unusual but fast-spreading necrotic infection of soft tissue relevant to high mortality rates. We report a case of postoperative gas gangrene of the pelvic wall, scrotum, and perineal site, with very acute onset and rapid progression of symptoms after laparoscopic radical resection for rectal cancer. Although potentially treatable with appropriate antibiotic cover and urgent thorough surgical debridement, this case still developed irreversibly into fulminant and fatal sepsis. The possible etiologic factors, better measures of diagnosis, and treatment are discussed, and the relevant literature is reviewed.<\/jats:p>","DOI":"10.3389\/fsurg.2022.822605","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T06:13:42Z","timestamp":1647584022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Clostridial Gas Gangrene of Pelvic Wall After Laparoscopic Rectal Cancer Surgery Induced Fatal Sepsis"],"prefix":"10.3389","volume":"9","author":[{"given":"Xing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simin","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0140-6736(00)87041-5","article-title":"Anaerobic infections of war wounds in the Middle East","volume":"242","author":"MacLennan","year":"1943","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1148\/radiographics.22.3.g02ma06543","article-title":"Emphysematous infections of the abdomen and pelvis: a pictorial review","volume":"22","author":"Grayson","year":"2002","journal-title":"Radiographics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1046\/j.1445-1433.2001.02231.x","article-title":"Clostridium septicum and malignancy","volume":"71","author":"Chew","year":"2001","journal-title":"ANZ J Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1097\/01.CCM.0000129486.35458.7D","article-title":"The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections","volume":"32","author":"Wong","year":"2004","journal-title":"Crit Care Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"bcr2017221980","DOI":"10.1136\/bcr-2017-221980","article-title":"Rare postoperative complication: Clostridium perfringens septic shock following elective abdominal surgery","volume":"2017","author":"Bath","year":"2017","journal-title":"BMJ Case Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"a1924","DOI":"10.1136\/bmj.a1924","article-title":"Prevention and treatment of surgical site infection: summary of NICE guidance","volume":"337","author":"Leaper","year":"2008","journal-title":"BMJ."},{"key":"B7","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s13104-016-2194-0","article-title":"A case of acute onset postoperative gas gangrene caused by Clostridium perfringens","volume":"9","author":"Takazawa","year":"2016","journal-title":"BMC Res Notes"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1056\/NEJMra1600673","article-title":"Necrotizing Soft-Tissue Infections","volume":"377","author":"Stevens","year":"2017","journal-title":"N Engl J Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/SLE.0000000000000294","article-title":"Clostridial gas gangrene of the abdominal wall after laparoscopic cholecystectomy: a case report and review","volume":"26","author":"Harmsen","year":"2016","journal-title":"Surg Laparosc Endosc Percutan Tech."},{"key":"B10","first-page":"1357","volume":"70","author":"Komatsu","year":"2012","journal-title":"Nihon Rinsho"},{"key":"B11","doi-asserted-by":"publisher","first-page":"28192","DOI":"10.1038\/srep28192","article-title":"Clostridium perfringens \u03b1-toxin impairs innate immunity via inhibition of neutrophil differentiation","volume":"6","author":"Takehara","year":"2016","journal-title":"Sci Rep."},{"key":"B12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1093\/jb\/mvh161","article-title":"Clostridium perfringens alpha-toxin: characterization and mode of action","volume":"136","author":"Sakurai","year":"2004","journal-title":"J Biochem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/bjs.1800800943","article-title":"Role of early and extensive surgery in the treatment of severe necrotizing soft tissue infection","volume":"80","author":"Voros","year":"1993","journal-title":"Br J Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1111\/os.12804","article-title":"Clostridial gas gangrene - 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