{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:38:20Z","timestamp":1791664700120,"version":"4.3.4"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Contradictory findings exist in studies comparing salpingectomy and proximal tubal occlusion (PTO) in treating hydrosalpinx patients before <jats:italic>in vitro<\/jats:italic> fertilization (IVF). Therefore, this meta-analysis aimed to comprehensively compare ovarian response, pregnancy outcomes, and complications between salpingectomy and PTO in treating these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Embase, PubMed, and Web of Science were searched to identify relevant articles published from 1980 to August 31, 2020. Eight studies that involve 716 hydrosalpinx patients before IVF were included, among whom 408 patients received salpingectomy and 308 patients received PTO. The data were pooled; the standardized mean difference (SMD) or odds ratio (OR) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Proximal tubal occlusion-treated patients had higher fertilization rate (SMD = 0.35, 95% CI: 0.11\u20130.59), while similar days of controlled ovarian hyperstimulation (COH) (SMD: 0.15, 95% CI: \u22120.36\u20130.67) and number of retrieved oocytes (SMD = \u22120.22, 95% CI: \u22120.54\u20130.10) compared with salpingectomy-treated patients. Furthermore, no difference of implantation rate (OR = 1.17, 95% CI: 0.62\u20132.20), clinical pregnancy rate (OR = 0.82, 95% CI: 0.59\u20131.15), ongoing pregnancy rate (OR = 0.64, 95% CI: 0.36\u20131.13), or live birth rate (OR = 0.67, 95% CI: 0.16\u20132.72) was shown between salpingectomy-treated patients and PTO-treated patients. Additionally, ectopic pregnancy rate (OR = 1.13, 95% CI: 0.21\u20135.92) and miscarriage rate (OR = 0.88, 95% CI: 0.31\u20132.48) were similar between salpingectomy-treated patients and PTO-treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Proximal tubal occlusion exhibits a higher fertilization rate but no obvious benefits on days of COH, number of retrieved oocytes, pregnancy outcomes, and complications over salpingectomy in hydrosalpinx patients before IVF.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.830612","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:47:46Z","timestamp":1651211266000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Ovarian Response, Pregnancy Outcomes, and Complications Between Salpingectomy and Proximal Tubal Occlusion in Hydrosalpinx Patients Before in vitro Fertilization: A Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Hua","family":"Ou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.bpobgyn.2019.01.011","article-title":"Hydrosalpinx - salpingostomy, salpingectomy or tubal occlusion","volume":"59","author":"Ng","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.jmig.2018.08.033","article-title":"Hysteroscopic placement of platinum microinsert in patients with hydrosalpinx before in vitro fertilization and embryo transfer","volume":"26","author":"Chen","year":"2019","journal-title":"J Minim Invasive Gynecol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3109\/01443615.2014.985768","article-title":"Management of hydrosalpinx before IVF: a literature review","volume":"35","author":"D'Arpe","year":"2015","journal-title":"J Obstet Gynaecol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/S0015-0282(00)01742-8","article-title":"Laparoscopic management of hydrosalpinges before in vitro fertilization-embryo transfer: salpingectomy versus proximal tubal occlusion","volume":"75","author":"Surrey","year":"2001","journal-title":"Fertil Steril."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1093\/humrep\/deg509","article-title":"Salpingectomy or proximal tubal occlusion of unilateral hydrosalpinx increases the potential for spontaneous pregnancy","volume":"18","author":"Sagoskin","year":"2003","journal-title":"Hum Reprod."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/j.fertnstert.2006.05.032","article-title":"Proximal tubal occlusion and salpingectomy result in similar improvement in in vitro fertilization outcome in patients with hydrosalpinx","volume":"86","author":"Kontoravdis","year":"2006","journal-title":"Fertil Steril."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1093\/humrep\/dew050","article-title":"Hysteroscopic proximal tubal occlusion versus laparoscopic salpingectomy as a treatment for hydrosalpinges prior to IVF or ICSI: an RCT","volume":"31","author":"Dreyer","year":"2016","journal-title":"Hum Reprod."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jmig.2018.10.013","article-title":"Ovarian reserve and assisted reproductive technique outcomes after laparoscopic proximal tubal occlusion or salpingectomy in women with hydrosalpinx undergoing in vitro fertilization: a randomized controlled trial","volume":"26","author":"Vignarajan","year":"2019","journal-title":"J Minim Invasive Gynecol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jmig.2019.02.026","article-title":"Proximal fallopian tubal embolization by interventional radiology prior to embryo transfer in infertile patients with hydrosalpinx: a prospective study of an off-label treatment","volume":"27","author":"Yang","year":"2020","journal-title":"J Minim Invasive Gynecol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1016\/j.jmig.2015.08.047","article-title":"Does the mode of surgery for hydrosalpinges affect outcome in in-vitro-fertilization (IVF) cycles? 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Results from a prospective, cross-sectional, single-center analysis","volume":"37","author":"Peluso","year":"2021","journal-title":"Gynecol Endocrinol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00404-018-5031-y","article-title":"PGR and PTX3 gene expression in cumulus cells from obese and normal weighting women after administration of long-acting recombinant follicle-stimulating hormone for controlled ovarian stimulation","volume":"299","author":"Burnik Papler","year":"2019","journal-title":"Arch Gynecol Obstet."}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.830612\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:47:47Z","timestamp":1651211267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.830612\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,29]]},"references-count":22,"alternative-id":["10.3389\/fsurg.2022.830612"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.830612","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,29]]},"article-number":"830612"}}