{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:37:14Z","timestamp":1787621834290,"version":"build-2736575974"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>We report an extremely rare case of metachronous double cancers of the bile duct and pancreas in a single patient who underwent successful curative resections consecutively. At the age of 57, a woman underwent pylorus-preserving pancreaticoduodenectomy for a lesion that was pathologically diagnosed as moderately differentiated adenocarcinoma of the distal common bile duct. Eighteen years later, a pancreatic mass was detected during a follow-up examination. Abdominal computed tomography showed a bigger 2.3\u2005cm lesion at the remnant pancreas body, which suggested a diagnosis of primary pancreatic cancer or metastasis. After admission and further work-up confirming no other lesions, completion total pancreatectomy was performed. The pathological diagnosis of the resected specimen was moderately differentiated pancreatic ductal adenocarcinoma, and this case highlights the occurrence of metachronous double primary cancers developed in both the distal bile duct and the pancreas with an interval of 18 years. This is the first report on the metachronous primary cancers of the bile duct and pancreas with a long interval within an English review of the literature in the MEDLINE. This case serves as another data point to guide surgeons that they should be vigilant for the postoperative long-term surveillance of patients with pancreatobiliary cancer.<\/jats:p>","DOI":"10.3389\/fsurg.2022.851524","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T05:43:09Z","timestamp":1661319789000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Metachronous pancreatic cancer 18 years after resection of common bile duct cancer: A case report"],"prefix":"10.3389","volume":"9","author":[{"given":"Seoung Hoon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/1097-0142(196103\/04)14:2<221::AID-CNCR2820140202>3.0.CO;2-6","article-title":"Multiple primary malignant neoplasms. 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Introduction and presentation of data","volume":"14","author":"Moertel","year":"1961","journal-title":"Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3075","DOI":"10.1002\/cncr.30164","article-title":"Risk of second primary malignancies among cancer survivors in the United States, 1992 through 2008","volume":"122","author":"Donin","year":"2016","journal-title":"Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3440","DOI":"10.3748\/wjg.15.3440","article-title":"Metachronous bile duct cancer nine years after resection of gallbladder cancer","volume":"15","author":"Joo","year":"2009","journal-title":"World J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1007\/s00423-015-1355-2","article-title":"Completion pancreatectomy for recurrent pancreatic cancer in the remnant pancreas: Report of six cases and a review of the literature","volume":"400","author":"Shima","year":"2015","journal-title":"Langenbecks Arch Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.4240\/wjgs.v2.i4.143","article-title":"Metachronous cancer of gallbladder and pancreas with pancreatobiliary maljunction","volume":"2","author":"Lahmar","year":"2010","journal-title":"World J Gastrointest Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"98","DOI":"10.4143\/crt.2017.595","article-title":"Validation of the eighth American Joint Committee on cancer staging system for distal bile duct carcinoma","volume":"51","author":"Jun","year":"2019","journal-title":"Cancer Res Treat"},{"key":"B7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.asjsur.2015.07.002","article-title":"Survival after surgical resection of distal cholangiocarcinoma: a systematic review and meta-analysis of prognostic factors","volume":"40","author":"Zhou","year":"2017","journal-title":"Asian J Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6658","DOI":"10.3748\/wjg.v20.i21.6658","article-title":"Prognostic factors in patients with middle and distal bile duct cancers","volume":"20","author":"Kwon","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.2147\/CMAR.S187614","article-title":"Second primary malignancy in patients with cholangiocarcinoma: A population-based study","volume":"11","author":"Zhuang","year":"2019","journal-title":"Cancer Manag Res"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.851524\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T05:43:11Z","timestamp":1661319791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.851524\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":9,"alternative-id":["10.3389\/fsurg.2022.851524"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.851524","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"article-number":"851524"}}