{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:36:56Z","timestamp":1783496216383,"version":"3.55.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160377"],"award-info":[{"award-number":["82160377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010265","name":"Guizhou Medical University","doi-asserted-by":"publisher","award":["gyfynsfc-2021-28"],"award-info":[{"award-number":["gyfynsfc-2021-28"]}],"id":[{"id":"10.13039\/501100010265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The chronic ischemic injury of the upper\/lower limbs caused by thromboangiitis obliterans (TAO, Buerger's disease) is difficult to heal, leading to high morbidity and amputation risk, seriously lowering the quality of life of patients. So far, the pathogenesis of this disease is still not clear, and there are still no effective therapeutic approaches. Here, we first use an improved bone transport technique to treat TAO-related foot ulcers and achieve good therapeutic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this report, 22 patients met the inclusion criteria, and we provide an improved bone transport technique to repair TAO-related chronic lower limb wounds, which have a minimally surgical incision and a satisfying surgical field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The improved bone transport technique resulted in TAO-related chronic lower extremity wound healing in most patients (18, M:F 16:2) within the first treatment cycle. All wounds healed completely after two treatment cycles. After these cycles, the cold sensation in the patients\u2019 feet was significantly relieved, and the rest pain in the lower extremities was significantly relieved (Visual Analog Scale, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.0001). Furthermore, the Laser Doppler flowmeter showed that the blood perfusion and percutaneous oxygen pressure of the affected foot were higher than in preoperation (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.0001). To conclude, bone transport technology is available for the refractory wounds of the extremity, which may promote healing by increasing blood circulation and tissue oxygen supply.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, the improved surgical method of the bone transport technique is worth considering in the treatment of thromboangiitis obliterans\u2013related foot ulcers.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.859201","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T07:59:51Z","timestamp":1660895991000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["An improved bone transport surgical method for treating chronic ischemic ulcers (thromboangiitis obliterans)"],"prefix":"10.3389","volume":"9","author":[{"given":"Liang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zairong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1161\/CIRCULATIONAHA.110.942383","article-title":"Thromboangiitis obliterans","volume":"121","author":"Piazza","year":"2010","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"156905","DOI":"10.1155\/2013\/156905","article-title":"Thromboangiitis obliterans (Buerger's Disease)\u2014current practices","volume":"2013","author":"Vijayakumar","year":"2013","journal-title":"Int J Inflam"},{"key":"B3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000512596","article-title":"Women and pregnancy in thromboangiitis obliterans","volume":"58","author":"Le Joncour","year":"2021","journal-title":"J Vasc Res"},{"key":"B4","first-page":"202","article-title":"Ueber eine igenth\u00fcmliche form von endarteritis und endophlebitis mit gangr\u00e4n des fu\u00dfes","volume":"23","author":"Winiwarter","year":"1879","journal-title":"Arch Klin Chir"},{"key":"B5","year":""},{"key":"B6","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1111\/os.13214","article-title":"Twenty years development of tibial cortex transverse transport surgery in PR China","volume":"14","author":"Liu","year":"2022","journal-title":"Orthop Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1097\/CORR.0000000000001075","article-title":"Proximal tibial cortex transverse distraction facilitating healing and limb salvage in severe and recalcitrant diabetic foot ulcers","volume":"478","author":"Chen","year":"2020","journal-title":"Clin Orthop Relat Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.3892\/etm.2018.6321","article-title":"Application of Ilizarov transverse tibial bone transport and microcirculation reconstruction in the treatment of chronic ischemic diseases in lower limbs","volume":"16","author":"Zuo","year":"2018","journal-title":"Exp Ther Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/J.JOT.2020.05.003","article-title":"Chinese Association of Orthopaedic Surgeons (CAOS) clinical guideline for the treatment of diabetic foot ulcers using tibial cortex transverse transport technique (version 2020)","volume":"25","author":"Hua","year":"2020","journal-title":"J Orthop Translat"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bjps.2016.07.012","article-title":"Vascularised bone transfer: history, blood supply and contemporary problems","volume":"70","author":"Sparks","year":"2017","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.injury.2011.05.021","article-title":"Treatment of complex fractures of the distal radius: a prospective randomised comparison of external fixation \u201cversus\u201d locked volar plating","volume":"43","author":"Jeudy","year":"2012","journal-title":"Injury"},{"key":"B12","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/iwj.12143","article-title":"Vessel transformation in chronic wounds under topical negative pressure therapy: an immunohistochemical analysis","volume":"12","author":"Malsiner","year":"2015","journal-title":"Int Wound J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/stem.3016","article-title":"Mesenchymal stem cells: from roots to boost","volume":"37","author":"Andrzejewska","year":"2019","journal-title":"Stem Cells"},{"key":"B14","doi-asserted-by":"publisher","first-page":"6218","DOI":"10.12998\/wjcc.v9.i22.6218","article-title":"Mesenchymal stem cell-derived exosomes: an emerging therapeutic strategy for normal and chronic wound healing","volume":"9","author":"Zeng","year":"2021","journal-title":"World J Clin Cases"},{"key":"B15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/bcpt.13478","article-title":"Mesenchymal stem cell\u2013derived small extracellular vesicles and bone regeneration","volume":"128","author":"Wang","year":"2021","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.859201\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T07:59:53Z","timestamp":1660895993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.859201\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":15,"alternative-id":["10.3389\/fsurg.2022.859201"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.859201","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]},"article-number":"859201"}}