{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:06:17Z","timestamp":1789574777668,"version":"build-2803163510"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2020J011096"],"award-info":[{"award-number":["2020J011096"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018534","name":"Fujian Provincial Medical Innovation Project","doi-asserted-by":"publisher","award":["2019-CXB-3, -4"],"award-info":[{"award-number":["2019-CXB-3, -4"]}],"id":[{"id":"10.13039\/501100018534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The analgesic effect produced by the intra-arterial injection of lidocaine in patients undergoing uterine artery embolization has been proven to be safe and effective. Nevertheless, a significant degree of pain is typically experienced after the operation, and pain management is crucial. Methylprednisolone, which provides an anti-inflammatory effect, is widely used in the treatment of several diseases. To date, methylprednisolone has not been used after uterine artery embolization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 131 patients with uterine leiomyoma were retrospectively enrolled. Forty-five patients (control group) were treated with embolized microspheres for bilateral uterine artery embolization. Fifty (study group) and 36 (lidocaine group) patients were administered lidocaine mixed with embolized microspheres during embolization, and in addition, the study group was administered methylprednisolone. Completed pain scales at different time points during surgery were obtained from patients undergoing uterine artery embolization. Efficacy against pain was evaluated by comparing the pain score, inflammatory index, and use of sufentanil within 24\u2005h followed by a Kruskal-Wallis Test and a least significant difference post-hoc analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The postoperative pain scores at 1, 4, and 7\u2005h after uterine artery embolization in the study group (3.08\u2009\u00b1\u20092.09, 2.46\u2009\u00b1\u20091.93, and 2.38\u2009\u00b1\u20091.85, respectively) were significantly lower than those in the control group (4.84\u2009\u00b1\u20092.36, 4.16\u2009\u00b1\u20091.87, and 3.56\u2009\u00b1\u20091.93, respectively) and the lidocaine group (3.50\u2009\u00b1\u20092.10, 3.30\u2009\u00b1\u20091.88, and 3.28\u2009\u00b1\u20091.89, respectively). At the first 24\u2005h after embolization, the total usage of sufentanil in the study group (31.4\u2009\u00b1\u20094.16) was significantly lower than those in the control group (45.7\u2009\u00b1\u20096.51) and the lidocaine group (38.3\u2009\u00b1\u20096.25). At 1 and 4\u2005h, the pain scores of the lidocaine group were significantly lower than those of the control group. In addition, at the first 24\u2005h after embolization, the total usage of sufentanil in the lidocaine group was significantly lower than that in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lidocaine in combination with methylprednisolone can significantly alleviate pain and reduce the usage of sufentanil after bilateral uterine artery embolization. Thus, methylprednisolone is a recommended addition to the therapeutic regimen after embolization.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.875484","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T12:34:42Z","timestamp":1650371682000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization"],"prefix":"10.3389","volume":"9","author":[{"given":"Yi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-nan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen-lin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-wei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-ting","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4125","DOI":"10.21037\/qims-20-1331","article-title":"Uterine artery embolization, surgery and high intensity focused ultrasound in the treatment of uterine fibroids: a network meta-analysis","volume":"11","author":"Gao","year":"2021","journal-title":"Quant Imaging Med Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bpobgyn.2017.09.003","article-title":"Uterine artery embolization: a review of current concepts","volume":"46","author":"Keung","year":"2018","journal-title":"Best Pract Res Clin yObstet Gynaecol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jvir.2016.10.001","article-title":"Intraarterial lidocaine for pain control in uterine artery embolization: a prospective, randomized study","volume":"28","author":"Noel-Lamy","year":"2017","journal-title":"J Vasc Interv Radiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1080\/01443615.2019.1575342","article-title":"Total laparoscopic hysterectomy for enlarged uteri: factors associated with the rate of conversion to open surgery","volume":"39","author":"Cianci","year":"2019","journal-title":"J Obstet Gynaecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1111\/j.1471-0528.2003.2045x.x","article-title":"Uterine artery embolisation for symptomatic fibroids: clinical results in 400 women with imaging follow up","volume":"110","author":"Manyonda","year":"2003","journal-title":"BJOG"},{"key":"B6","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1148\/radiol.2018172714","article-title":"Superior hypogastric nerve block as post-uterine artery embolization analgesia: a randomized and double-blind clinical trial","volume":"289","author":"Yoon","year":"2018","journal-title":"Radiology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1055\/s-0033-1359729","article-title":"Clinical and periprocedural pain management for uterine artery embolization","volume":"30","author":"Spencer","year":"2013","journal-title":"Semin Intervent Radiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1046\/j.1365-2168.1999.01014.x","article-title":"Cytolysis following chemoembolization for hepatocellular carcinoma","volume":"86","author":"Paye","year":"1999","journal-title":"Br J Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3390\/diagnostics10090659","article-title":"Postembolization syndrome after prostatic artery embolization: a systematic review","volume":"10","author":"Svarc","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1097\/NCC.0000000000000302","article-title":"Management of postembolization syndrome following hepatic transarterial chemoembolization for primary or metastatic liver cancer","volume":"39","author":"Blackburn","year":"2016","journal-title":"Cancer Nurs"},{"key":"B11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1148\/124.1.37","article-title":"The use of intra-arterial lidocaine to control pain due to aortofemoral arteriography","volume":"124","author":"Widrich","year":"1977","journal-title":"Radiology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jvir.2019.09.007","article-title":"Intra-arterial lidocaine administration for anesthesia after uterine artery embolization with trisacryl gelatin microspheres for leiomyoma","volume":"31","author":"Katsumori","year":"2020","journal-title":"J Vasc Interv Radiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1016\/j.ijcard.2012.06.002","article-title":"Glucocorticoid ameliorates early cardiac dysfunction after coronary microembolization and suppresses TGF-beta1\/Smad3 and CTGF expression","volume":"167","author":"Chen","year":"2013","journal-title":"Int J Cardiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"745 e1","DOI":"10.1016\/j.ajog.2016.06.051","article-title":"Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 10-year outcomes from the randomized EMMY trial","volume":"215","author":"de Bruijn","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.lpm.2019.03.012","article-title":"Uterine artery embolisation in women with symptomatic uterine fibroids","volume":"48","author":"Lohle","year":"2019","journal-title":"Presse Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"S240","DOI":"10.1002\/acr.20543","article-title":"Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP)","volume":"63","author":"Hawker","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1007\/s00330-005-2686-0","article-title":"Effectiveness of intra-arterial anesthesia for uterine fibroid embolization using dilute lidocaine","volume":"15","author":"Zhan","year":"2005","journal-title":"Eur Radiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2020.1847079","article-title":"Intra-arterial lidocaine for pain control after uterine artery embolization: a meta-analysis of randomized controlled trials","volume":"10","author":"Liu","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1148\/124.1.43","article-title":"Intra-arterial lidocaine: an effective analgesic for peripheral angiography","volume":"124","author":"Gordon","year":"1977","journal-title":"Radiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/s1051-0443(07)61592-9","article-title":"Intraarterial lidocaine for pain control after uterine artery embolization for leiomyomata","volume":"12","author":"Keyoung","year":"2001","journal-title":"J Vasc Interv Radiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.3892\/etm.2020.8652","article-title":"Significance of changes in inflammatory parameters following uterine artery embolization in pre-menopausal females","volume":"19","author":"Souftas","year":"2020","journal-title":"Exp Ther Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/bja\/aes431","article-title":"Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis","volume":"110","author":"Waldron","year":"2013","journal-title":"Br J Anaesth"},{"key":"B23","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s12903-021-01759-x","article-title":"Piezo-surgery technique and intramuscular dexamethasone injection to reduce postoperative pain after impacted mandibular third molar surgery: a randomized clinical trial","volume":"21","author":"Nehme","year":"2021","journal-title":"BMC Oral Health"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1111\/j.1398-9995.2011.02686.x","article-title":"New topics in bradykinin research","volume":"66","author":"Maurer","year":"2011","journal-title":"Allergy"},{"key":"B25","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s12079-021-00652-0","article-title":"A modular map of Bradykinin-mediated inflammatory signaling network","volume":"16","author":"Rex","year":"2022","journal-title":"J Cell Commun Signal"},{"key":"B26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.conctc.2018.09.006","article-title":"The rationale, design, and methods of a randomized, controlled trial to evaluate the efficacy of single-dose dexamethasone in reducing post-embolization syndrome in patients undergoing uterine artery embolization","volume":"12","author":"Wang","year":"2018","journal-title":"Contemp Clin Trials Commun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.cellimm.2007.05.003","article-title":"The differential effect of dexamethasone on granulocyte apoptosis involves stabilization of Mcl-1L in neutrophils but not in eosinophils","volume":"246","author":"Sivertson","year":"2007","journal-title":"Cell Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1213\/00000539-199001000-00003","article-title":"Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil","volume":"70","author":"Bailey","year":"1990","journal-title":"Anesth Analg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1007\/s00270-008-9430-5","article-title":"Pain levels within 24\u2005hours after UFE: a comparison of morphine and fentanyl patient-controlled analgesia","volume":"31","author":"Kim","year":"2008","journal-title":"Cardiovasc Intervent Radiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12959-021-00316-4","article-title":"A thrombophilia family with protein S deficiency due to protein translation disorders caused by a Leu607Ser heterozygous mutation in PROS1","volume":"19","author":"Zhang","year":"2021","journal-title":"Thrombosis Journal"},{"key":"B31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s42155-020-0099-4","article-title":"Intra-arterial lidocaine administration during uterine fibroid embolization to reduce the immediate postoperative pain: a prospective randomized study","volume":"3","author":"Duvnjak","year":"2020","journal-title":"CVIR Endovasc"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.875484\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T12:34:44Z","timestamp":1650371684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.875484\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":31,"alternative-id":["10.3389\/fsurg.2022.875484"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.875484","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"article-number":"875484"}}