{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T23:02:30Z","timestamp":1754262150255,"version":"3.41.2"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Olfactory neuroblastoma, or esthesioneuroblastoma, is an uncommon malignant tumor originating from the neural crest that commonly occurs in the upper nasal cavity. Its ectopic origin is extremely rare, especially when located in the optical pathways. This paper reports the case of a giant ectopic esthesioneuroblastoma of the optic pathways that were surgically treated through a cranio-orbital-zygomatic (COZ) craniotomy with extensive resection, in addition to a literature review. The patient is a 46-year-old female presenting with a 4-month history of visual loss in the left eye. Since she was previously blind in the right eye from a traumatic injury, it was evolving to loss of bilateral vision. Imaging depicted an expansive infiltrating lesion involving the entire path of the right optic nerve, extending to the optic chiasm, cisternal portion of the left optic nerve, bilateral optic tract, and hypothalamus. Investigation of pituitary function was unremarkable. Esthesioneuroblastoma is a rare tumor with poorly defined standard clinical management. Its ectopic presentation makes the diagnosis even more challenging, making it difficult to manage these cases properly. Surgeons should be aware of this rare possibility, as early aggressive treatment is likely to be associated with better results.<\/jats:p>","DOI":"10.3389\/fsurg.2022.875881","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T08:29:31Z","timestamp":1650356971000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Esthesioneuroblastoma Involving the Optic Pathways"],"prefix":"10.3389","volume":"9","author":[{"given":"Vithor Ely B.","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel R.","family":"Buniatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe D'Almeida","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio R.","family":"Torrecillas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean G.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio S.","family":"Rassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"B1","article-title":"Esthesioneuroblastoma","volume-title":"Treasure Island","author":"Limaiem","year":"2021"},{"key":"B2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.anl.2014.10.003","article-title":"Sphenoid esthesioneuroblastoma arising from the hindmost olfactory filament","volume":"42","author":"Matsunaga","year":"2015","journal-title":"Auris Nasus Larynx."},{"key":"B3","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1288\/00005537-199208000-00001","article-title":"Esthesioneuroblastoma: The UCLA Experience 1970-1990","volume":"102","author":"Dulguerov","year":"1992","journal-title":"Laryngoscope"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/1097-0142(197603)37:3<1571::AID-CNCR2820370347>3.0.CO;2-L","article-title":"Olfactory neuroblastoma\u2014A clinical analysis of 17 cases","volume":"37","author":"Kadish","year":"1976","journal-title":"Cancer"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01676830.2020.1852262","article-title":"Orbital invasion by Esthesioneuroblastoma: a comparative case series and review of literature","volume":"41","author":"Wu","year":"2020","journal-title":"Orbit."},{"key":"B6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s00405-010-1423-8","article-title":"Ectopic olfactory neuroblastoma: report of four cases and a review of the literature","volume":"268","author":"Wormald","year":"2011","journal-title":"Eur. Arch Oto-Rhino-Laryngology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12070-016-0978-0","article-title":"Ectopic esthesioneuroblastoma of the sphenoclivus: a rare entity","volume":"69","author":"Zahedi","year":"2017","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"key":"B8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/BF01808865","article-title":"Neuroblastoma of the olfactory nerve","volume":"25","author":"Jakumeit","year":"1971","journal-title":"Acta Neurochir"},{"key":"B9","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s11102-007-0081-3","article-title":"A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures","volume":"12","author":"Lin","year":"2009","journal-title":"Pituitary"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13014-019-1313-1","article-title":"Management of orbital invasion in esthesioneuroblastoma: 14 years' experience, Radiat","volume":"14","author":"Li","year":"2019","journal-title":"Oncol."}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.875881\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T08:29:33Z","timestamp":1650356973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.875881\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,19]]},"references-count":10,"alternative-id":["10.3389\/fsurg.2022.875881"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.875881","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2022,4,19]]},"article-number":"875881"}}