{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:16:04Z","timestamp":1793146564230,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Anastomotic leakage is a major complication in gastrointestinal and colorectal surgery and its occurrence increases morbidity and mortality. Its incidence is even higher in Crohn\u2019s disease surgeries. Several authors have identified factors involved in the pathophysiology of anastomotic leak in the literature, aiming to reduce its occurrence and, therefore, improve its surgical treatment. Surgical technique is the most discussed topic in studies on guiding the performance of side-to-side stapled anastomosis. Preoperative nutritional therapy also has been shown to reduce the risk of anastomotic leakage. Other factors remain controversial \u2013 immunomodulator use and biologic therapy, antibiotics, and gut microbiota \u2013 with studies showing a reduction in the risk of complication while other studies show no correlation. Although mesenteric adipose tissue has been related to disease recurrence, there is no evidence in the literature that it is related to a higher risk of anastomotic leakage. Further exploration on this topic is necessary, including prospective research, to support the development of techniques to prevent anastomotic leakage, in this way benefiting the inflammatory bowel disease patients who have to undergo a surgical procedure.<\/jats:p>","DOI":"10.3389\/fsurg.2022.882625","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T06:19:45Z","timestamp":1656051585000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Aspects Towards the Anastomotic Healing in Crohn\u2019s Disease: Clinical Approach and Current Gaps in Research"],"prefix":"10.3389","volume":"9","author":[{"given":"F.H.M.","family":"Chaim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.V.","family":"Negreiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Steigleder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.N.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.M.","family":"Genaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.P.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.R.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.S.","family":"Ayrizono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Fagundes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.F.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"604","DOI":"10.5009\/gnl19019","article-title":"Perspectives on current and novel treatments for inflammatory bowel disease","volume":"13","author":"Na","year":"2019","journal-title":"Gut Liver"},{"key":"B2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1590\/s0004-2803.202100000-87","article-title":"Epidemiological profile and clinical characteristics of inflammatory bowel diseases in a brazilian referral center","volume":"58","author":"Fucilini","year":"2021","journal-title":"Arq Gastroenterol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.21614\/chirurgia.113.2.227","article-title":"Reintervention rate following emergency surgery for crohn disease","volume":"113","author":"Slavu","year":"2018","journal-title":"Chirurgia (Bucur)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1067\/j.cpsurg.2018.05.001","article-title":"Role of surgery in the management of Crohn\u2019s disease","volume":"55","author":"Fichera","year":"2018","journal-title":"Curr Probl Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1097\/DCR.0000000000001590","article-title":"Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: results from an international snapshot audit","volume":"63","year":"2020","journal-title":"Dis Colon Rectum"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1097\/DCR.0000000000001202","article-title":"Different risk factors for early and late colorectal anastomotic leakage in a nationwide audit","volume":"61","author":"Sparreboom","year":"2018","journal-title":"Dis Colon Rectum"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1111\/codi.15839","article-title":"Ileorectal anastomosis in patients with Crohn\u2019s disease. 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