{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:03:45Z","timestamp":1754107425392,"version":"3.41.2"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Lymph node ratio (LNR) has been reported to reliably predict cancer-specific survival (CSS) in parotid gland cancer (PGC). Our study was designed to validate the significance of LNR in patients with PGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with stage I\u2013IV PGC were enrolled from Surveillance Epidemiology and End Results database (SEER, <jats:italic>N<\/jats:italic>\u2009=\u20093529), which is the training group, and Sun Yat-sen University Cancer Center database (SYSUCC, <jats:italic>N<\/jats:italic>\u2009=\u200999), the validation group. We used X-tile software to choose the optimal cutoff value of LNR; then, univariable and multivariable analyses were performed, assessing the association between LNR and CSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The optimal cutoff value of LNR was 0.32 by X-tile based on 3529 patients from SEER. Cox proportional hazard regression analysis revealed better CSS for patients with LNR\u2009\u2264\u20090.32 (adjusted hazard ratio [HR] 1.612, 95% confidence interval [95% CI] 1.286\u20132.019; <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) compared with patients with LNR\u2009&amp;gt;\u20090.32 in SEER. In the SYSUCC cohort, patients with LNR\u2009\u2264\u20090.32 also had better CSS over patients with LNR\u2009&amp;gt;\u20090.32 (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). In N2 and N3 stage groups, patients with LNR\u2009\u2264\u20090.32 had superior CSS outcomes over those with the LNR\u2009&amp;gt;\u20090.32 group, but this benefit was absent in the N1 stage group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, the lymph node ratio turned out to be an independent prognostic factor for cancer-specific survival of PGC in this study. This valuable information could help clinicians to evaluate the prognosis of PGC and suggest that adequate lymph node dissection is necessary.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.903576","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T07:13:38Z","timestamp":1652253218000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Prediction of Long-Term Survival Outcome by Lymph Node Ratio in Patients of Parotid Gland Cancer: A Retrospective study"],"prefix":"10.3389","volume":"9","author":[{"given":"Wen-Mei","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Feng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.oraloncology.2011.09.005","article-title":"Salivary gland carcinoma in Denmark 1990\u20132005: outcome and prognostic factors. 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