{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:25:30Z","timestamp":1780334730518,"version":"3.54.1"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Mucosal healing in the gut is an essential process when it comes to chronic inflammatory disorders such as inflammatory bowel diseases (IBD) but also to the creation of intestinal anastomosis. Despite an improvement of surgical techniques, the rates of anastomotic leakage remain substantial and represent a significant health-care and socio-economic burden. Recent research has focused on intrinsic factors such as mucosal linings and differences in the intestinal microbiota and identified specific endoluminal bacteria and epithelial proteins which influence intestinal wound healing and re-establishment of mucosal homeostasis. Despite the lack of large clinical studies, previous data indicate that the identified bacteria such as aerotolerant lactobacilli or wound-associated Akkermansia muciniphila as well as epithelial-expressed sialyl Lewis glycans or CD47 might be critical for wound and anastomotic healing in the gut, thus, providing a potential novel approach for future treatment strategies in colorectal surgery and IBD therapy. Since microbiota and mucosa are interacting closely, we outline the current discoveries about both subsets in this review together to demonstrate the significant interplay<\/jats:p>","DOI":"10.3389\/fsurg.2022.905049","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T11:59:20Z","timestamp":1658491160000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Mucosa and microbiota \u2013 the role of intrinsic parameters on intestinal wound healing"],"prefix":"10.3389","volume":"9","author":[{"given":"Matthias","family":"Kelm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Anger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1136\/gutjnl-2017-315568","article-title":"Natural disease course of Crohn\u2019s Disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study","volume":"68","author":"Burisch","year":"2019","journal-title":"Gut"},{"key":"B2","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1002\/bjs.9697","article-title":"Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks","volume":"102","author":"McDermott","year":"2015","journal-title":"Br J Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/ibd.20927","article-title":"Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn\u2019s disease","volume":"15","author":"Schnitzler","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","article-title":"3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: part 1: diagnosis and medical management","volume":"11","author":"Gomoll\u00f3n","year":"2017","journal-title":"J Crohns Colitis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5400","DOI":"10.2174\/1381612822666160726123857","article-title":"Pharmacological targeting of the inflamed intestinal barrier","volume":"22","author":"Farkas","year":"2016","journal-title":"Curr Pharm Des"},{"key":"B7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/01.mog.0000203864.48255.4f","article-title":"Regulation of the intestinal epithelial barrier by the apical junctional complex","volume":"22","author":"Laukoetter","year":"2006","journal-title":"Curr Opin Gastroenterol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e83688","DOI":"10.1371\/journal.pone.0083688","article-title":"Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer\u2019s Patches","volume":"8","author":"Ermund","year":"2013","journal-title":"PLoS One"},{"key":"B9","doi-asserted-by":"publisher","first-page":"G341","DOI":"10.1152\/ajpgi.00046.2013","article-title":"Studies of mucus in mouse stomach, small intestine, and colon. 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