{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:58:49Z","timestamp":1793444329602,"version":"4.5.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2020JH2\/10300161, 2021JH2\/10300062, 2020-KF-12-01"],"award-info":[{"award-number":["2020JH2\/10300161, 2021JH2\/10300062, 2020-KF-12-01"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"LiaoNing Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC2007053"],"award-info":[{"award-number":["XLYC2007053"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pump-controlled selective antegrade cerebral perfusion (PC-SACP) in total arch replacement (TAR) can regulate cerebral flow accurately, which might be beneficial for cerebral protection. However, the safety of PC-SACP for TAR combined with frozen elephant trunk implantation (FET) in patients with acute Type A dissections (ATAAD) is ambiguous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 192 patients with ATAAD underwent TAR at our institution from October 2019 to July 2021. The patients were divided into two groups based on PC-SACP used: PC group (SACP carried out by using a separate pump,<jats:italic>n<\/jats:italic>\u2009=\u200935) and Control group (SACP carried out as a traditional method,<jats:italic>n<\/jats:italic>\u2009=\u2009157). Patients under PC-SACP were propensity-score matched to patients without PC-SACP, resulting in 35 pairs of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Preoperative characteristics, including age, gender, weight, and preoperative creatinine level, were similar between the two groups. Cardiopulmonary bypass time, cross-clamp time, circulatory arrest time, and minimum nasopharyngeal temperature did not differ between the two groups. However, SACP time (54 versus 40,<jats:italic>P<\/jats:italic>\u2009=\u20090.001) in the PC group was significantly longer than that in the Control group. The incidence of temporary neurologic dysfunction (5.7% versus 8.6,<jats:italic>P<\/jats:italic>\u2009=\u20090.643) showed a no significantly lower trend in the PC group compared with the Control group. Other clinical outcomes showed no significant intergroup differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PC-SACP in TAR is safe and feasible and might be beneficial for avoiding brain injury caused by \u201cluxury\u201d perfusion.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.918461","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T07:08:47Z","timestamp":1660806527000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of pump-controlled selective antegrade cerebral perfusion in total arch replacement: A propensity-matched 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