{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:42:10Z","timestamp":1775547730843,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902983"],"award-info":[{"award-number":["81902983"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018JJB140382"],"award-info":[{"award-number":["2018JJB140382"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"\u201cThe Medical Excellence Award\u201d funded by the creative research development grant from the First Affiliated Hospital of Guangxi Medical University","doi-asserted-by":"publisher","award":["180327"],"award-info":[{"award-number":["180327"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Primary hepatic neuroendocrine carcinoma (PHNEC) manifests as a rare type of liver tumor. PHNEC is not specifically clinical or radiographical and is often misdiagnosed and mistreated. Here, we present a case report of PHNEC in a 50-year-old woman who was admitted to our department with concealed pain in the right upper abdomen. The initial diagnosis was a probable hepatic space-occupying lesion with tumor bleeding. The patient was subjected to a partial right hemihepatectomy, cholecystectomy, partial resection of the lower lobe of the right lung, partial resection of the diaphragm, and resection of the right perirenal fat sac to alleviate her symptoms. After surgery, gene sequencing was performed to determine the possible cause of the condition. However, five months after discharge, the patient was hospitalized again because of retroperitoneal and peritoneal multiple metastases. Nine months after surgery, the patient died. This case is likely to aid in furthering our understanding of PHNEC to improve the future diagnosis and treatment of this disease.<\/jats:p>","DOI":"10.3389\/fsurg.2022.920276","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T06:09:11Z","timestamp":1657865351000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature"],"prefix":"10.3389","volume":"9","author":[{"given":"Keyu","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhujing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weitao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jilong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banghao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9191639","DOI":"10.1155\/2018\/9191639","article-title":"Comparative clinical analysis of gastroenteropancreatic neuroendocrine carcinomas with liver metastasis and primary hepatic neuroendocrine carcinomas","volume":"2018","author":"Qiu","year":"2018","journal-title":"Dis Markers"},{"key":"B2","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12957-021-02187-5","article-title":"Combined primary hepatic neuroendocrine carcinoma and hepatocellular carcinoma: case report and literature review","volume":"19","author":"Nakano","year":"2021","journal-title":"World J Surg Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1136\/jclinpath-2016-203941","article-title":"Clinicopathological features of neoplasms with neuroendocrine differentiation occurring in the liver","volume":"70","author":"Nomura","year":"2017","journal-title":"J Clin Pathol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 who classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s12328-016-0669-0","article-title":"Histological features of mixed neuroendocrine carcinoma and hepatocellular carcinoma in the liver: a case report and literature review","volume":"9","author":"Nishino","year":"2016","journal-title":"Clin J Gastroenterol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.anndiagpath.2005.04.013","article-title":"Primary hepatic neuroendocrine carcinoma: an underdiagnosed entity","volume":"10","author":"Dala","year":"2006","journal-title":"Ann Diagn Pathol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0090-1229(81)90136-7","article-title":"Neuroendocrine neoplasms in unusual primary sites","volume":"4","author":"Gould","year":"1981"},{"key":"B8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejso.2005.11.017","article-title":"Liver resection for primary hepatic neuroendocrine tumours: report of three cases and review of the literature","volume":"32","author":"Donadon","year":"2006","journal-title":"Eur J Surg Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1109\/49.725182","article-title":"Primary hepatic endocrinomas (carcinoids and variant neoplasms). A statistical evaluation of 126 reported cases","volume":"21","author":"Soga","year":"2002","journal-title":"J Exp Clin Cancer Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1245\/aso.2003.04.533","article-title":"Long-Term survival after resection for primary hepatic carcinoid tumor","volume":"10","author":"Knox","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"B11","first-page":"746","article-title":"Primary hepatic carcinoid tumor: case report and review of 53 cases","volume":"7","author":"Iwao","year":"2001","journal-title":"Med Sci Monit"},{"key":"B12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.4021\/wjon341w","article-title":"Primary hepatic neuroendocrine tumor: what do we know now?","volume":"2","author":"Quartey","year":"2011","journal-title":"World J Oncol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1757-1626-2-90","article-title":"Primary hepatic carcinoid tumor: a case report and review of the literature","volume":"2","author":"Lin","year":"2009","journal-title":"Cases J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40644-017-0120-x","article-title":"Primary hepatic neuroendocrine tumors: multi-modal imaging features with pathological correlations","volume":"17","author":"Yang","year":"2017","journal-title":"Cancer Imaging"},{"key":"B15","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s40792-021-01315-3","article-title":"Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report","volume":"7","author":"Seki","year":"2021","journal-title":"Surg Case Rep"},{"key":"B16","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.wneu.2020.01.169","article-title":"Computed tomography and magnetic resonance imaging in the diagnosis of primary neuroendocrine tumors of the liver","volume":"138","author":"Yulong","year":"2020","journal-title":"World Neurosurg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1186\/s12885-021-08337-y","article-title":"Development of a nomogram model to predict survival outcomes in patients with primary hepatic neuroendocrine tumors based on seer database","volume":"21","author":"Zhang","year":"2021","journal-title":"BMC Cancer"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12907-018-0070-7","article-title":"Primary hepatic neuroendocrine carcinoma: report of two cases and literature review","volume":"18","author":"Zhao","year":"2018","journal-title":"BMC Clin Pathol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/MPA.0b013e3181ebaffd","article-title":"Nanets consensus guidelines for the diagnosis of neuroendocrine tumor","volume":"39","author":"Vinik","year":"2010","journal-title":"Pancreas"},{"key":"B20","doi-asserted-by":"publisher","first-page":"9085","DOI":"10.2147\/cmar.S343572","article-title":"Efficacy of chemotherapy versus transcatheter arterial chemoembolization in patients with advanced primary hepatic neuroendocrine carcinoma and an analysis of the prognostic factors: a retrospective study","volume":"13","author":"Li","year":"2021","journal-title":"Cancer Manag Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"8604","DOI":"10.3892\/ol.2018.8413","article-title":"Analysis of the clinicopathological features and prognostic factors of primary hepatic neuroendocrine tumors","volume":"15","author":"Chen","year":"2018","journal-title":"Oncol Lett"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.920276\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T06:09:16Z","timestamp":1657865356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.920276\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,15]]},"references-count":21,"alternative-id":["10.3389\/fsurg.2022.920276"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.920276","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,15]]},"article-number":"920276"}}