{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:31:58Z","timestamp":1769823118470,"version":"3.49.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pseudomyxoma peritonei (PMP) is a rare disease, with the overall survival (OS) influenced by many factors. To date, no ascites characteristics have been reported to predict OS of patients with PMP. The present study therefore aims to describe the ascites characteristics for PMP and identify prognostic factors for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between June 2010 and June 2020, 473 PMP patients who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were included in a retrospective study. Survival analysis was performed with the Kaplan\u2013Meier method by the log-rank test and a Cox proportional hazards model. Associations between categorical variables were analyzed using the chi-squared test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all included patients, 61% were women. The median OS was 47 months (range, 4\u2013124 months) at the last follow-up in December 2020. Ascites characteristics can be divided into light blood ascites, \u201cJelly\u201d mucus ascites, and faint yellow and clear ascites. Multivariate Cox analysis showed that the degree of radical surgery, ascites characteristics, and pathological grade were independently associated with OS in PMP patients. The chi-squared test documented that faint yellow \u201cJelly\u201d ascites were related to low-grade PMP and light blood ascites were associated with high-grade PMP (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Light blood ascites, incomplete cytoreduction surgery, and high-grade histopathology may predict poor OS in appendix-derived PMP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.967296","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T05:03:05Z","timestamp":1673845385000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of the ascites characteristics in pseudomyxoma peritonei originating from the appendix"],"prefix":"10.3389","volume":"9","author":[{"given":"Bing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xibo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenpeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huazhen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxiu","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benqiang","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1080\/02656736.2017.1310938","article-title":"Pseudomyxoma peritonei: natural history and treatment","volume":"33","author":"Mittal","year":"2017","journal-title":"Int J Hyperthermia"},{"key":"B2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejso.2020.02.012","article-title":"Appendiceal tumours and pseudomyxoma peritonei: literature review with PSOGI\/EURACAN clinical practice guidelines for diagnosis and treatment","volume":"47","author":"Govaerts","year":"2021","journal-title":"Eur J Surg Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13023-021-01723-6","article-title":"Consensuses and controversies on pseudomyxoma peritonei: a review of the published consensus statements and guidelines","volume":"16","author":"Lin","year":"2021","journal-title":"Orphanet J Rare Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1245\/s10434-020-08655-8","article-title":"Estimating the prevalence of pseudomyxoma peritonei in Europe using a novel statistical method","volume":"28","author":"Patrick-Brown","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1053\/ejso.2000.1038","article-title":"Cytoreductive surgery and peri-operative intraperitoneal chemotherapy as a curative approach to pseudomyxoma peritonei syndrome","volume":"27","author":"Sugarbaker","year":"2001","journal-title":"Eur J Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.7497\/j.issn.2095-3941.2014.04.008","article-title":"Report on the 9(th) international congress on peritoneal surface malignancies","volume":"11","author":"Li","year":"2014","journal-title":"Cancer Biol Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1002\/jso.26671","article-title":"Nomogram to predict overall survival of patients with pseudomyxoma peritonei of appendiceal origin: a retrospective cohort study","volume":"124","author":"Bai","year":"2021","journal-title":"J Surg Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00000658-199501000-00004","article-title":"Peritonectomy procedures","volume":"221","author":"Sugarbaker","year":"1995","journal-title":"Ann Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/jso.21388","article-title":"Surgical technique of parietal and visceral peritonectomy for peritoneal surface malignancies","volume":"100","author":"Deraco","year":"2009","journal-title":"J Surg Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1245\/s10434-021-10725-4","article-title":"Nomogram to predict incomplete cytoreduction for pseudomyxoma peritonei","volume":"29","author":"Bai","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1200\/JCO.2011.39.7166","article-title":"Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"30","author":"Chua","year":"2012","journal-title":"J Clin Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/PAS.0000000000000535","article-title":"A consensus for classification and pathologic reporting of pseudomyxoma Peritonei and associated appendiceal neoplasia: the results of the peritoneal surface oncology group international (PSOGI) modified Delphi process","volume":"40","author":"Carr","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"7809","DOI":"10.1245\/s10434-021-10093-z","article-title":"Managing recurrent pseudomyxoma peritonei in 430 patients after complete cytoreduction and HIPEC: a dilemma for patients and surgeons","volume":"28","author":"Ahmadi","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.ejso.2012.06.552","article-title":"Evaluation of complete cytoreductive surgery and two intraperitoneal chemotherapy techniques in Pseudomyxoma peritonei","volume":"38","author":"S\u00f8rensen","year":"2012","journal-title":"Eur J Surg Oncol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/145749691009900406","article-title":"Clinical presentation of pseudomyxoma peritonei","volume":"99","author":"J\u00e4rvinen","year":"2010","journal-title":"Scand J Surg"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7343","DOI":"10.3748\/wjg.v21.i24.7343","article-title":"Perioperative chemotherapy for resectable gastric cancer: MAGIC and beyond","volume":"21","author":"Choi","year":"2015","journal-title":"World J Gastroenterol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s10151-020-02289-4","article-title":"Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review","volume":"24","author":"Arredondo","year":"2020","journal-title":"Tech Coloproctol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ygyno.2014.07.004","article-title":"The impacts of neoadjuvant chemotherapy and of debulking surgery on survival from advanced ovarian cancer","volume":"134","author":"Rosen","year":"2014","journal-title":"Gynecol Oncol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/ans.18041","article-title":"Preoperative systemic chemotherapy does not benefit for appendiceal pseudomyxoma peritonei","author":"Ma","year":"2022","journal-title":"ANZ J Surg"},{"key":"B20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/SLA.0b013e31818eec64","article-title":"Pseudomyxoma peritonei: biological features are the dominant prognostic determinants after complete cytoreduction and hyperthermic intraperitoneal chemotherapy","volume":"249","author":"Baratti","year":"2009","journal-title":"Ann Surg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1245\/s10434-007-9691-2","article-title":"Pseudomyxoma peritonei: clinical pathological and biological prognostic factors in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)","volume":"15","author":"Baratti","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1007\/s13304-020-00788-5","article-title":"Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in pseudomyxoma peritonei of appendiceal origin: result of a single centre study","volume":"72","author":"Di Leo","year":"2020","journal-title":"Updates Surg"},{"key":"B23","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s11605-019-04239-4","article-title":"Outcomes following cytoreduction and HIPEC for pseudomyxoma peritonei: 10-year experience","volume":"24","author":"Narasimhan","year":"2020","journal-title":"J Gastrointest Surg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.suronc.2019.03.004","article-title":"Survival after complete cytoreductive surgery and HIPEC for extensive pseudomyxoma peritonei","volume":"29","author":"Benhaim","year":"2019","journal-title":"Surg Oncol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"715119","DOI":"10.3389\/fsurg.2021.715119","article-title":"Cytoreduction and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendiceal origin: a single center experience","volume":"8","author":"Santullo","year":"2021","journal-title":"Front Surg"},{"key":"B26","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1245\/s10434-017-6252-1","article-title":"Validation of the recent PSOGI pathological classification of pseudomyxoma peritonei in a single-center series of 265 patients treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"25","author":"Dario","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1023\/A:1006792007063","article-title":"Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice","volume":"17","author":"Kanayama","year":"1999","journal-title":"Clin Exp Metastasis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1007\/s00432-020-03321-8","article-title":"The biological basis and function of GNAS mutation in pseudomyxoma peritonei: a review","volume":"146","author":"Lin","year":"2020","journal-title":"J Cancer Res Clin Oncol"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.967296\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T05:03:08Z","timestamp":1673845388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.967296\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,16]]},"references-count":28,"alternative-id":["10.3389\/fsurg.2022.967296"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.967296","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,16]]},"article-number":"967296"}}