{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:34:41Z","timestamp":1753893281044,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Uterine leiomyomas are the most common gynecological tumors in women of child-bearing age and premenopausal women, while benign metastasizing leiomyomas of the heart are rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report a rare case of metastasizing leiomyoma in the heart of a 54-year-old woman 10 years after a uterine leiomyoma was discovered during hysterectomy. Echocardiography, cardiac plain scan and enhanced MRI at presentation showed a soft tissue signal mass in the right ventricle. A large cardiac mass attached to the chordae of the tricuspid valve and later shown to be histopathologically consistent with uterine leiomyoma was successfully resected through a right atriotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our case report highlights a rare type of tumor of the heart and suggests that metastasizing leiomyoma should be considered in the differential diagnosis of right-sided cardiac tumors. The complete surgical resection of the tumor was considered to be the best treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2022.991558","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T06:45:32Z","timestamp":1661237132000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: Cardiac metastatic leiomyoma in an Asian female"],"prefix":"10.3389","volume":"9","author":[{"given":"Juan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang-Ye","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Qing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Lan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.athoracsur.2009.06.050","article-title":"Benign metastasizing leiomyoma: a rare metastatic lesion in the right ventricle","volume":"89","author":"Galvin","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s004280000207","article-title":"Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases","volume":"437","author":"Kayser","year":"2000","journal-title":"Virchows Archiv"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1016\/S0003-4975(03)01196-2","article-title":"Surgical resection of ventricular cardiac fibromas: early and late results","volume":"76","author":"Cho","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE Guidelines for case reports: explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J Clin Epidemiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1056\/NEJM198010303031806","article-title":"Intracardiac spread of intravenous leiomyomatosis with successful surgical excision","volume":"303","author":"Timmis","year":"1980","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/S0344-0338(96)80116-6","article-title":"Metastasizing uterine leiomyoma. A case with cardiac and pulmonary metastasis","volume":"192","author":"Takemura","year":"1996","journal-title":"Pathol Res Pract"},{"key":"B7","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00059-013-3904-1","article-title":"Benign metastasizing leiomyoma","volume":"39","author":"Cai","year":"2014","journal-title":"Case report and review of the literature. Herz"},{"key":"B8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.14797\/mdcj-10-4-251","article-title":"Metastasizing leiomyoma to heart","volume":"10","author":"Consamus","year":"2014","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1016\/j.jtcvs.2015.09.059","article-title":"Right ventricular and epicardial tumors from benign metastasizing uterine leiomyoma","volume":"151","author":"Williams","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"7231326","DOI":"10.1155\/2018\/7231326","article-title":"The heart as a site of metastasis of benign metastasizing leiomyoma: case report and review of the literature","volume":"2018","author":"Meddeb","year":"2018","journal-title":"Case Rep Cardiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jaccas.2019.12.004","article-title":"Suspicious right heart mass: a rare case of benign metastasizing leiomyoma of the tricuspid valve","volume":"2","author":"Gad","year":"2020","journal-title":"JACC Case Rep"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e197066","DOI":"10.14503\/THIJ-19-7066","article-title":"Benign metastasizing leiomyoma in the heart of a 45-year-old woman","volume":"48","author":"Karnib","year":"2021","journal-title":"Tex Heart Inst J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/OGX.0b013e3181d60f93","article-title":"Pathogenesis of benign metastasizing leiomyoma: a review","volume":"65","author":"Awonuga","year":"2010","journal-title":"Obstet Gynecol Surv"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1210\/jc.2003-032021","article-title":"Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature","volume":"89","author":"Rivera","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"B15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/000331979204300310","article-title":"Intracardiac extension of a calcified ovarian hemangioma\u2013a case report","volume":"43","author":"Tamburino","year":"1992","journal-title":"Angiology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.prp.2010.10.004","article-title":"Intravenous lipoleiomyomatosis of uterus with cardiac extension: a case report","volume":"207","author":"Vural","year":"2011","journal-title":"Pathol Res Pract"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1056\/NEJM199510123331519","article-title":"Extension of a pelvic tumor into the right atrium","volume":"333","author":"Stancanelli","year":"1995","journal-title":"N Engl J Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1046\/j.1525-1438.2003.13008.x","article-title":"Intravenous leiomyomatosis with atypical histologic features: a case report","volume":"13","author":"Lam","year":"2003","journal-title":"Int J Gynecol Cancer"},{"key":"B19","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/modpathol.3880529","article-title":"Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case","volume":"15","author":"Quade","year":"2002","journal-title":"Mod Pathol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1016\/0002-8703(84)90705-1","article-title":"Tricuspid valve obstruction due to intravenous leiomyomatosis","volume":"108","author":"Gonzalez-Lavin","year":"1984","journal-title":"Am Heart J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1536\/ihj.25.651","article-title":"Intravenous leiomyomatosis of the uterus with continuous extension into the pulmonary artery","volume":"25","author":"Akatsuka","year":"1984","journal-title":"Jpn Heart J"},{"key":"B22","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1365-2559.1988.tb02066.x","article-title":"Intravenous leiomyomatosis: a case report emphasizing the vascular component","volume":"13","author":"Ohmori","year":"1988","journal-title":"Histopathology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"906109","DOI":"10.5402\/2012\/906109","article-title":"Primary cardiac tumours: a single-center 41-year experience","volume":"2012","author":"Steger","year":"2012","journal-title":"ISRN Cardiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1093\/ejcts\/ezr067","article-title":"Primary benign cardiac tumours: long-term results","volume":"41","author":"Pacini","year":"2012","journal-title":"Eur J Cardio-Thorac Surg"},{"key":"B25","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3978\/j.issn.2072-1439.2012.05.07","article-title":"Clinicopathologic analysis of cardiac myxomas: seven years\u2019 experience with 61 patients","volume":"4","author":"Wang","year":"2012","journal-title":"J Thorac Dis"},{"key":"B26","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/BF00197559","article-title":"Leiomyomatosis with vascular invasion. A unified pathogenesis regarding leiomyoma with vascular microinvasion, benign metastasizing leiomyoma and intravenous leiomyomatosis","volume":"425","author":"Canzonieri","year":"1994","journal-title":"Virchows Archiv"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.991558\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T06:45:36Z","timestamp":1661237136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2022.991558\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":26,"alternative-id":["10.3389\/fsurg.2022.991558"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2022.991558","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2022,8,23]]},"article-number":"991558"}}