{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:55:19Z","timestamp":1787500519023,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Multiple myeloma (MM) is a hematological malignancy with characteristic clonal plasma cell proliferation and production of monoclonal immunoglobulins. Although it can often metastasize to the bony spine, completely extravertebral and extra-\/intradural manifestations are exceedingly rare. In this case report, we describe a 51-year-old male patient with cervical extradural and intraforaminal MM who was surgically treated in our department. Clinical findings and radiological images were retrieved from medical records and an imaging system. This unusual localization of MM and similar cases in the literature are reviewed in detail. The patient underwent tumor resection via a ventral approach, and postoperative MRI demonstrated a sufficient decompression of neural structures. No new neurological deficits were observed at subsequent follow-ups. Although 7 cases of extramedullary extradural manifestations of multiple myeloma have been described in the literature so far, this is the first case of intraforaminal extramedullary multiple myeloma located in the cervical spine and treated by surgery.<\/jats:p>","DOI":"10.3389\/fsurg.2023.1011152","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:53:08Z","timestamp":1675050788000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multiple myeloma presenting as a cervical intraforaminal tumor: A case report and review of literature"],"prefix":"10.3389","volume":"10","author":[{"given":"Dragan","family":"Jankovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Kalasauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naureen","family":"Keric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Ottenhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ringel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-3-540-85772-3_2","article-title":"Epidemiology of multiple myeloma","volume":"183","author":"Becker","year":"2011","journal-title":"Recent Results Cancer Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e3148","DOI":"10.7759\/cureus.3148","article-title":"An overview of light chain multiple myeloma: clinical characteristics and rarities, management strategies, and disease monitoring","volume":"10","author":"Rafae","year":"2018","journal-title":"Cureus"},{"key":"B3","first-page":"277","article-title":"Multiple myeloma associated with extramedullary plasmacytoma causing nerve root compression: a case report","volume":"100","author":"Hu","year":"2001","journal-title":"J Formos Med Assoc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.beha.2005.01.024","article-title":"Neurological aspects of multiple myeloma and related disorders","volume":"18","author":"Dispenzieri","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1016\/j.spinee.2010.01.007","article-title":"Isolated extraosseous epidural myeloma presenting with thoracic compressive myelopathy","volume":"10","author":"Avadhani","year":"2010","journal-title":"Spine J"},{"key":"B6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jbspin.2007.01.044","article-title":"Extraosseous epidural multiple myeloma presenting with thoracic spine compression","volume":"75","author":"Okacha","year":"2008","journal-title":"Joint Bone Spine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1046\/j.1440-1819.2000.00767.x","article-title":"Extraosseous epidural IgD myeloma presenting with compression myelopathy","volume":"54","author":"Watanabe","year":"2000","journal-title":"Psychiatry Clin Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1097\/00002517-199209000-00017","article-title":"Extraosseous epidural tumor of immunoglobulin D myeloma","volume":"5","author":"Matsui","year":"1992","journal-title":"J Spinal Disord"},{"key":"B9","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/jcp.47.7.669","article-title":"IgD multiple myeloma with thoracic spine compression due to epidural extra-osseous tumour spread","volume":"47","author":"Lolin","year":"1994","journal-title":"J Clin Pathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/0720-048x(96)00754-1","article-title":"Extraosseous, epidural tumour spread of multiple myeloma","volume":"22","author":"Palmbach","year":"1996","journal-title":"Eur J Radiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/cncr.26447","article-title":"Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: a retrospective survey of 50 patients","volume":"118","author":"Gozzetti","year":"2012","journal-title":"Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e899","DOI":"10.7759\/cureus.899","article-title":"Multiple myeloma associated chronic inflammatory demyelinating polyradiculoneuropathy: the importance of continued surveillance","volume":"8","author":"Fasanya","year":"2016","journal-title":"Cureus"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1111\/j.1468-1331.2011.03380.x","article-title":"Neuropathy and paraproteins: review of a complex association","volume":"18","author":"Rajabally","year":"2011","journal-title":"Eur J Neurol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/brain\/118.2.359","article-title":"Long-term follow-up of patients with chronic inflammatory demyelinating polyradiculoneuropathy, without and with monoclonal gammopathy","volume":"118","author":"Simmons","year":"1995","journal-title":"Brain"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e203","DOI":"10.1016\/j.lpm.2013.01.056","article-title":"Chronic inflammatory demyelinating polyradiculoneuropathy","volume":"42","author":"Van den Bergh","year":"2013","journal-title":"Presse Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jns.2016.01.055","article-title":"Ultrasound of the nerves\u2014an appropriate addition to nerve conduction studies to differentiate paraproteinemic neuropathies","volume":"362","author":"Athanasopoulou","year":"2016","journal-title":"J Neurol Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13256-020-02496-5","article-title":"Multiple myeloma presenting as an intramedullary spinal cord tumor: a case report and review of the literature","volume":"14","author":"Di","year":"2020","journal-title":"J Med Case Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bjhh.2017.09.004","article-title":"Multiple myeloma and central nervous system involvement: experience of a Brazilian center","volume":"40","author":"Dias","year":"2018","journal-title":"Rev Bras Hematol Hemoter"},{"key":"B19","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.clml.2016.08.010","article-title":"Myelomatous involvement of the central nervous system","volume":"16","author":"Paludo","year":"2016","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"B20","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/ajh.24351","article-title":"Central nervous system involvement by multiple myeloma: a multi-institutional retrospective study of 172 patients in daily clinical practice","volume":"91","author":"Jurczyszyn","year":"2016","journal-title":"Am J Hematol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3109\/10428199809057562","article-title":"Multiple myeloma in young patients: clinical presentation and treatment approach","volume":"30","author":"Blad\u00e9","year":"1998","journal-title":"Leuk Lymphoma"},{"key":"B22","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/annonc\/mdp329","article-title":"Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients","volume":"21","author":"Varettoni","year":"2010","journal-title":"Ann Oncol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"521","DOI":"10.7326\/0003-4819-110-7-521","article-title":"High serum levels of lactic dehydrogenase identify a high-grade lymphoma-like myeloma","volume":"110","author":"Barlogie","year":"1989","journal-title":"Ann Intern Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"931","DOI":"10.7326\/0003-4819-115-12-931","article-title":"High serum lactate dehydrogenase level as a marker for drug resistance and short survival in multiple myeloma","volume":"115","author":"Dimopoulos","year":"1991","journal-title":"Ann Intern Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e341","DOI":"10.1038\/bcj.2015.48","article-title":"Factors influencing extramedullary relapse after allogeneic transplantation for multiple myeloma","volume":"5","author":"Vincent","year":"2015","journal-title":"Blood Cancer J"},{"key":"B26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1600-0609.2004.00331.x","article-title":"Features of extramedullary and extraosseous multiple myeloma: a report of 19 patients from a single center","volume":"73","author":"Damaj","year":"2004","journal-title":"Eur J Haematol"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1011152\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:53:09Z","timestamp":1675050789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1011152\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":26,"alternative-id":["10.3389\/fsurg.2023.1011152"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2023.1011152","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"article-number":"1011152"}}