{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:08:53Z","timestamp":1791954533296,"version":"4.3.4"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In this work, we studied the clinical effect of liposuction followed by lymphovenous anastomosis (LVAs) for the treatment of breast cancer-related lymphedema (BCRL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 158 patients with unilateral upper limb BCRL who underwent liposuction followed by LVAs 2\u20134 months later. Arm circumferences before and 7 days after the combined treatments were prospectively recorded. Circumferences of different upper extremities were measured before the procedure, 7 days after LVAs, and during the follow-ups. Volumes were calculated with the frustum method. During the follow-ups, the conditions of patients\u2019 treated arms, i.e., the frequency of erysipelas episodes and dependence on compression garments, were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean circumference difference between two upper limbs decreased significantly from M (P25, P75) of 5.3 (4.1, 6.9) preoperatively to 0.5 (\u22120.8, 1.0) (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05) 7\u2005days after treatments, while at follow-up 0.3 (\u22120.4, 1.0). The mean volume difference decreased significantly from M (P25, P75) of 838.3 (662.4, 1,129.0) preoperatively to 7.8 (\u2212120.3, 151.4) (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05) 7 days after treatments, while at follow-up 43.7 (\u221259.4, 161.1). The incidence of erysipelas also significantly decreased (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05). 6.3% of patients were already independent of compression garments during the past six months or even more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liposuction followed by LVAs is an effective method for the treatment of BCRL.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2023.1065733","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T04:53:26Z","timestamp":1678856006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["A clinical study of liposuction followed by lymphovenous anastomosis for treatment of breast cancer-related lymphedema"],"prefix":"10.3389","volume":"10","author":[{"given":"Kun","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.critrevonc.2014.06.004","article-title":"Lymphedema following breast cancer treatment and impact on quality of life: a review","volume":"92","author":"Taghian","year":"2014","journal-title":"Crit Rev Oncol Hematol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/s00520-018-4418-4","article-title":"\u201cIt still affects our economic situation\u201d: long-term economic burden of breast cancer and lymphedema","volume":"27","author":"Dean","year":"2019","journal-title":"Support Care Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jaad.2008.04.013","article-title":"Lower extremity lymphedema update: pathophysiology, diagnosis, and treatment guidelines","volume":"59","author":"Kerchner","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3322\/caac.21253","article-title":"Recent progress in the treatment and prevention of cancer-related lymphedema","volume":"65","author":"Shaitelman","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"B5","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1053\/j.sempedsurg.2014.07.004","article-title":"Lymphedema","volume":"23","author":"Maclellan","year":"2014","journal-title":"Semin Pediatr Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10549-017-4221-9","article-title":"Changes in arm tissue composition with slowly progressive weight-lifting among women with breast cancer-related lymphedema","volume":"164","author":"Zhang","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.1200\/JCO.2007.14.4899","article-title":"Lymphedema after breast cancer: incidence, risk factors, and effect on upper body function","volume":"26","author":"Hayes","year":"2008","journal-title":"J Clin Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.21037\/gs.2017.11.04","article-title":"Breast cancer-related lymphedema: risk factors, precautionary measures, and treatments","volume":"7","author":"Gillespie","year":"2018","journal-title":"Gland Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.breast.2018.12.009","article-title":"Tackling the diversity of breast cancer related lymphedema: perspectives on diagnosis, risk assessment, and clinical management","volume":"44","author":"Michelotti","year":"2019","journal-title":"Breast"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.3109\/02841860903061683","article-title":"Physical activity for the affected limb and arm lymphedema after breast cancer surgery. 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