{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:51:18Z","timestamp":1792043478115,"version":"4.4.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Schwannomas are benign tumors originating from Schwann cells, frequently occurring in the spinal cord and peripheral nerves. Intraosseous schwannomas, a rare subset, account for approximately 0.2% of schwannomas. Intraosseous schwannomas commonly impinge the mandible, followed by the sacrum and the spine. By far, only three cases of radius intraosseous schwannomas have been reported in PubMed. The tumor was treated differently in all three cases, resulting in different outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 29-year-old male construction engineer who complained of a painless mass on the radial aspect of the right forearm was diagnosed with an intraosseous schwannoma of the radius based on radiography, three-dimensional computed tomography reconstruction, magnetic resonance imaging, pathological examination, and immunohistochemistry. A different surgical approach was employed to reconstruct the radial graft defect using bone microrepair techniques, resulting in more reliable bone healing and early functional recovery. Meanwhile, no clinical and radiographic findings suggestive of recurrence were observed at the 12-month follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vascularized bone flap transplantation combined with three-dimensional imaging reconstruction planning might yield better results for repairing small segmental bone defects of the radius caused by intraosseous schwannomas.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2023.1108942","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:55:40Z","timestamp":1677153340000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Successful management of a rare radius schwannoma mimicking malignant bone tumors: A case report and literature review"],"prefix":"10.3389","volume":"10","author":[{"given":"Nianzhe","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar Zeb","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lushan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.3892\/ol.2016.4363","article-title":"Association between intraosseous schwannoma occurrence and the position of the intraosseous nutrient vessel: a case report","volume":"11","author":"Suzuki","year":"2016","journal-title":"Oncol Lett"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e407","DOI":"10.1016\/j.spinee.2015.12.028","article-title":"Intraosseous schwannoma of the sacrum","volume":"16","author":"Mutlu","year":"2016","journal-title":"Spine J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.joms.2017.12.017","article-title":"Intraosseous schwannoma of the jaws: an updated review of the literature and report of 2 new cases affecting the mandible","volume":"76","author":"Perkins","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"300060520987732","DOI":"10.1177\/0300060520987732","article-title":"First-ever intraosseous ancient schwannoma of the proximal ulna successfully treated using the cement technique","volume":"49","author":"Lim","year":"2021","journal-title":"J Int Med Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"11448","DOI":"10.12998\/wjcc.v9.i36.11448","article-title":"Giant schwannoma of thoracic vertebra: a case report","volume":"9","author":"Zhou","year":"2021","journal-title":"World J Clin Cases"},{"key":"B6","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jbspin.2016.07.009","article-title":"Multi-imaging modalities of intraosseous schwannoma of the scapula","volume":"84","author":"Nguyen","year":"2017","journal-title":"Jt Bone Spine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1302\/0301-620X.90B6.19901","article-title":"Schwannoma of the fibula","volume":"90","author":"Palocaren","year":"2008","journal-title":"J Bone Joint Surg Br"},{"key":"B8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.wneu.2019.08.157","article-title":"Intraosseous petrous apex schwannoma: case report and review of literature","volume":"132","author":"Rozman","year":"2019","journal-title":"World Neurosurg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1007\/s00381-018-3820-z","article-title":"Intraosseous schwannoma of the occipital bone: a case report","volume":"34","author":"Mathieu","year":"2018","journal-title":"Childs Nerv Syst"},{"key":"B10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3928\/01477447-20080301-16","article-title":"Intraosseous schwannoma of the frontal bone","volume":"31","author":"Goyal","year":"2008","journal-title":"Orthopedics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.clinimag.2014.09.005","article-title":"Intraosseous schwannoma of the ilium","volume":"39","author":"Kato","year":"2015","journal-title":"Clin Imaging"},{"key":"B12","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1055\/s-0031-1280975","article-title":"Schwannoma presenting with anteromedial knee pain and bone defect","volume":"26","author":"Karthik","year":"2013","journal-title":"J Knee Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e307","DOI":"10.1097\/SCS.0000000000003557","article-title":"Surgical management of mandibular intraosseous schwannomas","volume":"28","author":"DeLeonibus","year":"2017","journal-title":"J Craniofac Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/01.blo.0000203485.90711.1b","article-title":"Vascularized iliac bone graft for iliosacral bone defect after tumor excision","volume":"447","author":"Nishida","year":"2006","journal-title":"Clin Orthop Relat Res"},{"key":"B15","first-page":"115","article-title":"Volar distal radius vascularized bone graft vs non-vascularized bone graft: a prospective comparative study","volume":"34","author":"Smeraglia","year":"2020","journal-title":"J Biol Regul Homeost Agents"},{"key":"B16","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s00264-016-3339-4","article-title":"Preliminary results of managing large medial tibial defects in primary total knee arthroplasty: autogenous morcellised bone graft","volume":"41","author":"Sugita","year":"2017","journal-title":"Int Orthop"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1007\/s00167-018-5254-2","article-title":"Comparable bone union progression after opening wedge high tibial osteotomy using allogenous bone chip or tri-calcium phosphate granule: a prospective randomized controlled trial","volume":"27","author":"Lee","year":"2019","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"B18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/978-1-4471-5451-8_137","article-title":"The tension-stress effect on the genesis and growth of tissues: part II. The influence of the rate and frequency of distraction","author":"Ilizarov","year":"1989","journal-title":"Clin Orthop Relat Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"3219","DOI":"10.1177\/0300060518774992","article-title":"Bone transport for reconstruction of large bone defects after tibial tumor resection: a report of five cases","volume":"46","author":"Yang","year":"2018","journal-title":"J Int Med Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.2106\/JBJS.18.00842","article-title":"Bone repair using the Masquelet Technique","volume":"101","author":"Masquelet","year":"2019","journal-title":"J Bone Joint Surg Am"},{"key":"B21","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s12891-015-0689-9","article-title":"Mid-term clinical results of primary total knee arthroplasty using metal block augmentation and stem extension in patients with rheumatoid arthritis","volume":"16","author":"Hamai","year":"2015","journal-title":"BMC Musculoskelet Disord"},{"key":"B22","doi-asserted-by":"publisher","first-page":"104461","DOI":"10.1016\/j.jmbbm.2021.104461","article-title":"Titanium mesh-reinforced calcium sulfate for structural bone grafts","volume":"118","author":"Cavelier","year":"2021","journal-title":"J Mech Behav Biomed Mater"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3659","DOI":"10.1016\/j.bioactmat.2021.03.030","article-title":"Three-dimensional-printed individualized porous implants: a new \u201cimplant-bone\u201d interface fusion concept for large bone defect treatment","volume":"6","author":"Zhang","year":"2021","journal-title":"Bioactive Mater"},{"key":"B24","first-page":"227","article-title":"Neurilemmoma causing a defect in the radius","volume":"41","author":"Dabrowski","year":"1976","journal-title":"Chir Narzadow Ruchu Ortop Pol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1053\/jhsu.2000.jhsu25a0365","article-title":"Intraosseous neurilemmoma of the radius: a case report","volume":"25","author":"Gin\u00e9","year":"2000","journal-title":"J Hand Surg Am"},{"key":"B26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.5146\/tjpath.2010.01020","article-title":"Intraosseous schwannoma of the radius","volume":"26","author":"Ba\u011fci","year":"2010","journal-title":"Turk J Pathol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/BF01678983","article-title":"Cellular schwannoma. A clinicopathologic study of 29 cases","volume":"416","author":"Lodding","year":"1990","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"B28","first-page":"271","article-title":"Solitary intraosseous neurilemmoma of the tibia: review of intraosseous neurilemmoma and neurofibroma","author":"Gordon","year":"1976","journal-title":"Clin Orthop Relat Res"},{"key":"B29","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/S0046-8177(84)80009-X","article-title":"Intraosseous schwannoma: histologic features, ultrastructure, and review of the literature","volume":"15","author":"de la Monte","year":"1984","journal-title":"Hum Pathol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1177\/1971400918782321","article-title":"Intraosseous schwannomas involving the sacrum: characteristic imaging findings and review of the literature","volume":"31","author":"Summers","year":"2018","journal-title":"Neuroradiol J"},{"key":"B31","first-page":"209","article-title":"Benign retroperitoneal pelvic schwannoma. Apropos of 2 cases","volume":"127","author":"Rattier","year":"1990","journal-title":"J Chir"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e617","DOI":"10.1016\/j.wneu.2018.08.135","article-title":"Prognostic analysis of clinical and immunohistochemical factors for patients with spinal schwannoma","volume":"120","author":"Li","year":"2018","journal-title":"World Neurosurg"},{"key":"B33","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/PAI.0b013e318244ff4b","article-title":"Sox10 and S100 in the diagnosis of soft-tissue neoplasms","volume":"20","author":"Karamchandani","year":"2012","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1302\/0301-620X.89B3.18123","article-title":"Benign solitary schwannomas: a review of 234 cases","volume":"89","author":"Knight","year":"2007","journal-title":"J Bone Joint Surg Br"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1108942\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:55:44Z","timestamp":1677153344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1108942\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":34,"alternative-id":["10.3389\/fsurg.2023.1108942"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2023.1108942","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,23]]},"article-number":"1108942"}}