{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:35:01Z","timestamp":1753893301465,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871214"],"award-info":[{"award-number":["31871214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>With the introduction of the concept of mesopancreas defining the perineural structures that includes neurovascular bundle and lymph nodes extending from the posterior surface of the pancreatic head to behind the mesenteric vessels,Total Mesopancreas Excision (TMpE) based on this theory has facilitated the development of pancreatic cancer surgery in clinical practice in recent years. However, the existence of so called mesopancreas in the human body is still in debate and the comparative study of mesopancreas of rhesus monkey and human have not been well investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of our study is to compare the pancreatic vessels and fascia of human and rhesus monkeys in anatomical and embryological perspectives and to support the utilization of rhesus monkey as animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 20 rhesus monkey cadavers were dissected and their mesopancreas location, relationships and arterial distribution were analyzed. We compared the location and developmental patterns of mesopancreas in macaques and humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that the distribution of pancreatic arteries in rhesus monkeys was the same as that in humans, which is consistent with phylogenetic similarities. However, the morphological features of the mesopancreas and greater omentum is anatomically different from that of humans, including (1) the greater omentum is not connected to the transverse colon in monkeys. (2) The presence of the dorsal mesopancreas of the rhesus monkey suggests that it be an intraperitoneal organ. Comparative anatomical studies of mesopancreas and arteries in macaques and humans showed characteristic patterns of mesopancreas and similarities in pancreatic artery development in nonhuman primates, consistent with phylogenetic differentiation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2023.1112316","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T14:23:57Z","timestamp":1685715837000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative study of pancreatic vessels and mesopancreas of rhesus monkeys and humans"],"prefix":"10.3389","volume":"10","author":[{"given":"Fan","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.13918\/j.issn.2095-8137.2014.6.447","article-title":"Experimental primates and non-human primate (nhp) models of human diseases in China: current Status and progress","volume":"35","author":"Zhang","year":"2014","journal-title":"Dongwuxue Yanjiu"},{"key":"B2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/med.0000000000000043","article-title":"The nonhuman primate as a model for type 2 diabetes","volume":"21","author":"Pound","year":"2014","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B3","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","article-title":"The use of animal models in diabetes research","volume":"166","author":"King","year":"2012","journal-title":"Br J Pharmacol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1600-0684.2011.00499.x","article-title":"Pancreas anatomy and surgical procedure for pancreatectomy in rhesus monkeys","volume":"40","author":"Zhang","year":"2011","journal-title":"J Med Primatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1477-7819-5-44","article-title":"Resection of the mesopancreas (Rmp): a new surgical classification of a known anatomical space","volume":"5","author":"Gockel","year":"2007","journal-title":"World J Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4186","DOI":"10.1007\/s00464-019-06994-6","article-title":"Follow \u201cthe superior mesenteric artery\u201d: laparoscopic approach for total mesopancreas excision during pancreaticoduodenectomy","volume":"33","author":"Morales","year":"2019","journal-title":"Surg Endosc"},{"key":"B7","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/2013-08-009","article-title":"Retroportal lamina or mesopancreas? Lessons learned by anatomical and histological study of thirty-three cadaveric dissections","volume":"11","author":"Mahdi","year":"2013","journal-title":"Int J Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"256","DOI":"10.14740\/gr1225","article-title":"Pancreaticoduodenectomy with arterial approach of total mesenteric resection of the pancreas for pancreatic head cancer","volume":"12","author":"Du","year":"2019","journal-title":"Gastroenterology Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s12094-018-1869-5","article-title":"Systematic review of the mesopancreas: concept and clinical implications","volume":"20","author":"Ramia","year":"2018","journal-title":"Clin Transl Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.ejso.2011.12.015","article-title":"Surgical technique and results of total mesopancreas excision (Tmpe) in pancreatic tumors","volume":"38","author":"Adham","year":"2012","journal-title":"Eur J Surg Oncol"},{"key":"B11","first-page":"202","article-title":"Total meso-pancreas excision: key point of resection in pancreatic head adenocarcinoma","volume":"58","author":"Popescu","year":"2011","journal-title":"Hepatogastroenterology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.7150\/jca.21341","article-title":"Total mesopancreas excision for the treatment of pancreatic head cancer","volume":"8","author":"Xu","year":"2017","journal-title":"J Cancer"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1007\/s00423-021-02211-y","article-title":"What do surgeons need to know about the mesopancreas","volume":"406","author":"Eduardo","year":"2021","journal-title":"Langenbeck Arch Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.6092\/1590-8577\/3818","article-title":"Mesopancreas: myth or reality","volume":"11","author":"Manish","year":"2010","journal-title":"JOP"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1097\/CM9.0000000000000219","article-title":"Shark mouth pancreaticojejunostomy: a new enteric reconstruction procedure of pancreatic stump","volume":"132","author":"Wang","year":"2019","journal-title":"Chin Med J (Engl)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1745-6215-13-45","article-title":"Pancreatogastrostomy versus pancreatojejunostomy for reconstruction after partial pancreatoduodenectomy (recopanc): study protocol of a randomized controlled trial Utn U1111-1117-9588","volume":"13","author":"Wellner","year":"2012","journal-title":"Trials"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s00276-020-02547-y","article-title":"The mesopancreas and pancreatic head Plexus: morphological, developmental, and clinical perspectives","volume":"42","author":"Yi","year":"2020","journal-title":"Surg Radiol Anat"},{"key":"B18","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/jmor.20783","article-title":"Links between the discovery of primates and anatomical comparisons with humans, the chain of being, our place in nature, and racism","volume":"279","author":"Diogo","year":"2018","journal-title":"J Morphol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1002\/jhbp.402","article-title":"Mesopancreas is a misnomer: time to correct the nomenclature","volume":"23","author":"Sharma","year":"2016","journal-title":"J Hepatobiliary Pancreat Sci"},{"volume-title":"Gray\u2019s anatomy E-book: The anatomical basis of clinical practice","year":"2021","author":"Standring","key":"B20"},{"key":"B21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10353-018-0535-z","article-title":"A comprehensive study of the mesopancreas as an extension of the pancreatic circumferential resection margin","volume":"50","author":"Maplanka","year":"2018","journal-title":"Eur Surg"},{"key":"B22","doi-asserted-by":"publisher","first-page":"423","DOI":"10.21147\/j.issn.1000-9604.2016.04.05","article-title":"Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases","volume":"28","author":"Wu","year":"2016","journal-title":"Chin J Cancer Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ijsu.2022.106559","article-title":"Impact of total mesopancreas excision on postoperative tumor recurrence","volume":"100","author":"Serrablo-Requejo","year":"2022","journal-title":"Int J Surg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3441","DOI":"10.1007\/s00268-020-05605-z","article-title":"Vascular anatomy of mesopancreas in pancreatoduodenectomy using an intestinal derotation procedure","volume":"44","author":"Sugiyama","year":"2020","journal-title":"World J Surg"},{"key":"B25","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-71963-0","volume-title":"The mesenteric organ in health and disease","author":"Ehrenpreis","year":"2021"},{"key":"B26","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1293\/tox.2016-0016","article-title":"A comparison of the anatomical structure of the pancreas in experimental animals","volume":"29","author":"Tsuchitani","year":"2016","journal-title":"J Toxicol Pathol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1006\/cbir.1996.0013","article-title":"The non-human primate endocrine pancreas: development, regeneration potential and metaplasia","volume":"20","author":"Wolfe-Coote","year":"1996","journal-title":"Cell Biol Int"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1112316\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T14:24:04Z","timestamp":1685715844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1112316\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":27,"alternative-id":["10.3389\/fsurg.2023.1112316"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2023.1112316","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2023,6,2]]},"article-number":"1112316"}}