{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:59:43Z","timestamp":1776128383932,"version":"3.50.1"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101126"],"award-info":[{"award-number":["82101126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Skin regeneration is a challenging issue worldwide. Increasing research has highlighted the role of immune cells in healing and the underlying regulatory mechanism. The purpose of this study was to identify the hotspots and trends in skin regeneration and inflammation research through bibliometrics and to provide insights into the future development of fundamental research and disease treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Publications were collected from the Web of Science Core Collection on March 1, 2022. Articles and reviews published in English from January 1, 1999, to December 31, 2022, were selected, and statistical analyses of countries, institutions, authors, references, and keywords were performed using VOSviewer 1.6.18 and CiteSpace 5.8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,894 articles and reviews were selected. The number of publications on skin inflammation and regeneration showed an increasing trend over time. Additionally, authors and institutions in the United States, United Kingdom, Canada, and China appeared to be at the forefront of research in the field of skin inflammation and regeneration. Werner Sabine published some of the most cited papers. <jats:italic>Wound Repair and Regeneration<\/jats:italic> was the most productive journal, while <jats:italic>Journal of Investigative Dermatology<\/jats:italic> was the most cited journal. Angiogenesis, diamonds, collagen, cytokine, and keratinocytes were the five most commonly used keywords.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The number of publications on skin inflammation and regeneration show an increasing trend. Moreover, a series of advanced technologies and treatments for skin regeneration, such as exosomes, hydrogels, and wound dressings, are emerging, which will provide precise information for the treatment of skin wounds. This study can enhance our understanding of current hotspots and future trends in skin inflammation and regeneration research, as well as provide guidelines for fundamental research and clinical treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2023.1180624","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T04:35:34Z","timestamp":1682051734000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["A bibliometric analysis of hotpots and trends for the relationship between skin inflammation and regeneration"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhen-jiang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-ting","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jhin.2020.04.014","article-title":"The effectiveness of germicidal wipes and ultraviolet irradiation in reducing bacterial loads on electronic tablet devices used to obtain patient information in orthopaedic clinics: evaluation of tablet cleaning methods","volume":"105","author":"Allen","year":"2020","journal-title":"J Hosp Infect"},{"key":"B2","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1046\/j.1523-1747.2002.01845.x","article-title":"Mechanisms underlying the suppression of established immune responses by ultraviolet radiation","volume":"119","author":"Nghiem","year":"2002","journal-title":"J Invest Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/wrr.13042","article-title":"Local burn wound environment versus systemic response: comparison of proteins and metabolites","volume":"30","author":"Zang","year":"2022","journal-title":"Wound Repair Regen"},{"key":"B4","doi-asserted-by":"publisher","first-page":"123158","DOI":"10.1016\/j.ijbiomac.2023.123158","article-title":"A wet-adhesive carboxymethylated yeast beta-glucan sponge with radical scavenging, bacteriostasis and anti-inflammatory functions for rapid hemostasis","volume":"230","author":"Zhou","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"tkac003","DOI":"10.1093\/burnst\/tkac003","article-title":"Autophagy and skin wound healing","volume":"10","author":"Ren","year":"2022","journal-title":"Burns Trauma"},{"key":"B6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s13287-019-1312-z","article-title":"Epidermal stem cells in wound healing and their clinical applications","volume":"10","author":"Yang","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"B7","doi-asserted-by":"publisher","first-page":"8430","DOI":"10.7150\/thno.59661","article-title":"Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration","volume":"11","author":"Ebner-Peking","year":"2021","journal-title":"Theranostics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2147\/CCID.S196364","article-title":"The regenerative potential of skin and the immune system","volume":"12","author":"Tsepkolenko","year":"2019","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.4103\/1673-5374.346545","article-title":"PANoptosis-like cell death in ischemia\/reperfusion injury of retinal neurons","volume":"18","author":"Yan","year":"2023","journal-title":"Neural Regen Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s13287-020-01796-3","article-title":"Progress in studies of epidermal stem cells and their application in skin tissue engineering","volume":"11","author":"Yang","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"B11","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1001\/jama.1968.03140020066016","article-title":"Elie Metchnikoff (1845\u20131916), advocate of phagocytosis","volume":"203","author":"Metchnikoff","year":"1968","journal-title":"JAMA"},{"key":"B12","first-page":"71","article-title":"The role of the macrophage in wound repair. 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