{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:37:18Z","timestamp":1778575038891,"version":"3.51.4"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Thrombocytopenia and poor prognosis in severe conditions are associated. However, the clinical significance of thrombocytopenia in pyogenic liver abscess (PLA) has not been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the association between thrombocytopenia and the prognosis of patients with PLA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A consecutive case series of 458 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, China) between October 2011 and June 2021 was included in this cross-sectional analysis. Patient data were compared between the thrombocytopenia and non-thrombocytopenia groups. Multivariate logistic regression, receiver operating characteristic (ROC) curve and propensity score -matched analyses (PSM) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 458 patients with PLA, 94 (20.5%) developed thrombocytopenia, 19 (4.1%) developed septic shock, 14 (3.1%) were admitted to the ICU, and 15 (3.3%) died during hospitalization. Thrombocytopenia was independently associated with shock (95%CI\u2009=\u20093.529\u201357.944, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001), ICU admission (95%CI\u2009=\u20091.286\u201325.733, <jats:italic>P<\/jats:italic>\u2009=\u20090.022), and mortality (95%CI\u2009=\u20091.947\u201334.223, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) in multivariate regression analysis. ROC analysis showed that thrombocytopenia may be an identified marker of shock [area under the ROC curve (AUC), 0.8119; cut-off, 92.50; <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.0001], ICU admission (AUC, 0.7484; cut-off, 82.50; <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.0015), and mortality (AUC, 0.7827; cut-off, 122.50; <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.002). These findings remained consistent across 86 pairs of patients analyzed for PSM analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thrombocytopenia is an independent risk factor for poor prognosis in PLA and patients may be more prone to adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2023.1192523","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:11:09Z","timestamp":1690272669000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case 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