{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:29:18Z","timestamp":1787027358039,"version":"build-2736575974"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>The brachial cleft carcinoma is an extremely rare head and neck facial malignancy, and there is some disagreement about its differential diagnosis. In this paper, we report a 63-year-old male patient who had a mass on the left side of the neck and diagnosed as the brachial cleft carcinoma by intraoperative biopsy pathology. However, this patient was diagnosed with the carcinoma of the left soft palate more than 20 days after surgery and esophageal cancer 2 years later, and was treated accordingly. Therefore, it is hard to confirm whether the branchial cleft carcinoma is primary or metastatic. In fact, the diagnostic criteria for primary squamous cell carcinoma of branchial cleft cysts are very rigorous. Confirmation of the diagnosis is based on pathological examination of the branchial cleft cyst epithelium lined with squamous cells, meanwhile, a thorough examination should also be performed to exclude the presence of other primary cancers.<\/jats:p>","DOI":"10.3389\/fsurg.2023.1205287","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T03:23:46Z","timestamp":1695266626000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary or metastatic branchial cleft carcinoma?: a case report"],"prefix":"10.3389","volume":"10","author":[{"given":"Yang","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lungang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10006-009-0156-6","article-title":"Branchial cleft cysts in adults. Diagnostic procedures and treatment in a series of 18 cases","volume":"13","author":"Papadogeorgakis","year":"2009","journal-title":"Oral Maxillofac Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"5081540","DOI":"10.1155\/2018\/5081540","article-title":"Congenital midline cervical cleft and W-plasty: our experience","volume":"2018","author":"Bahakim","year":"2018","journal-title":"Int J Otolaryngol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/MOO.0b013e32835cebde","article-title":"Branchial cleft cyst carcinoma: fact or fiction","volume":"21","author":"Bradley","year":"2013","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1097\/00000658-195011000-00002","article-title":"The case for branchiogenic cancer (malignant branchioma)","volume":"132","author":"Martin","year":"1950","journal-title":"Ann Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/(sici)1097-0142(19980301)82:5%3C944::aid-cncr21%3E3.0.co;2-#","article-title":"The clinical importance of cystic squamous cell carcinomas in the neck: a study of 136 cases","volume":"82","author":"Thompson","year":"1998","journal-title":"Cancer"},{"key":"B6","doi-asserted-by":"publisher","first-page":"384, 387","DOI":"10.1177\/014556130108000608","article-title":"A new case of a branchial cyst of the parapharyngeal space","volume":"80","author":"Bilgen","year":"2001","journal-title":"Ear Nose Throat J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.amjoto.2006.06.005","article-title":"Primary branchiogenic carcinoma: the confusion continues","volume":"28","author":"Maturo","year":"2007","journal-title":"Am J Otolaryngol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.oraloncology.2004.09.016","article-title":"Cystic lymph node metastases of head and neck squamous cell carcinoma: pitfalls and controversies","volume":"41","author":"Mallet","year":"2005","journal-title":"Oral Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1002\/hed.10118","article-title":"Carcinoma in situ in a lateral cervical cyst","volume":"24","author":"Zimmermann","year":"2002","journal-title":"Head Neck"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1097\/00005537-200010000-00012","article-title":"Incidence of unsuspected metastases in lateral cervical cysts","volume":"110","author":"Gourin","year":"2000","journal-title":"Laryngoscope"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1038\/sj.bjc.6690229","article-title":"Cystic lymph node metastases of squamous cell carcinoma of Waldeyer\u2019s ring origin","volume":"79","author":"Regauer","year":"1999","journal-title":"Br J Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1258\/0022215054273241","article-title":"Post-operative adjuvant chemoradiotherapy with carboplatin and 5-fluorouracil for primary branchiogenic carcinoma","volume":"119","author":"Katori","year":"2005","journal-title":"J Laryngol Otol"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1205287\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T03:23:47Z","timestamp":1695266627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2023.1205287\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":12,"alternative-id":["10.3389\/fsurg.2023.1205287"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2023.1205287","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]},"article-number":"1205287"}}