{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:11:00Z","timestamp":1780510260692,"version":"3.54.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe a case of utero-ovarian transposition (UOT) before pelvic radiation in a patient with rectal cancer and provide a systematic literature review on all reported cases of UOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective collection and revision of clinical, intraoperative, and postoperative data from a patient who underwent UOT. In addition, a systematic review of the literature available to date on all cases of UOT was realized, and 14 patients from 10 articles were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We reported the case of a 28-year-old nulligravida patient who was diagnosed with a low-grade rectal adenocarcinoma and underwent neoadjuvant chemoradiotherapy, followed by transanal total mesorectal excision (TaTME). Before starting neoadjuvant oncological therapies, the patient underwent laparoscopic UOT. The intervention was performed without complications, and the patient received neoadjuvant oncological treatments as planned. TaTME and uterus repositioning were completed six weeks after the end of radiotherapy. No complications were observed during the first 9 postoperative months. Adequate utero-ovarian perfusion was assessed by Doppler ultrasound, cervicovaginal anastomosis appeared to have healed correctly, and the patient experienced menstrual bleeding. Data from the literature review of all reported cases of UOT were presented and discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>UOT represents a valuable option to preserve fertility in patients requiring pelvic radiotherapy. This study provides additional evidence on the feasibility and safety of performing UOT.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2024.1336047","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T04:23:31Z","timestamp":1708921411000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Utero-ovarian transposition before pelvic radiation in a patient with rectal cancer: a case report and systemic literature review"],"prefix":"10.3389","volume":"11","author":[{"given":"Daniela","family":"Huber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Simonson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Dischl-Antonioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Pena Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaline","family":"Francey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Surbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Hurni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw322","article-title":"Colorectal cancer incidence patterns in the United States, 1974\u20132013","volume":"109","author":"Siegel","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3322\/caac.21601","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"B4","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/oncolo\/oyac052","article-title":"Fertility preservation discussions between young adult rectal cancer survivors and their providers: sex-specific prevalence and correlates","volume":"27","author":"Stal","year":"2022","journal-title":"Oncologist"},{"key":"B5","year":""},{"key":"B6","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.fertnstert.2019.06.029","article-title":"Advances in fertility-preservation surgery: navigating new frontiers","volume":"112","author":"Christianson","year":"2019","journal-title":"Fertil Steril"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.ijrobp.2008.12.016","article-title":"Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients","volume":"73","author":"Wo","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"B8","doi-asserted-by":"publisher","first-page":"482968","DOI":"10.1155\/2014\/482968","article-title":"The impact of uterine radiation on subsequent fertility and pregnancy outcomes","volume":"2014","author":"Teh","year":"2014","journal-title":"Biomed Res Int"},{"key":"B9","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.fertnstert.2017.06.016","article-title":"Uterine transposition: technique and a case report","volume":"108","author":"Ribeiro","year":"2017","journal-title":"Fertil Steril"},{"key":"B10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.ygyno.2018.05.009","article-title":"Uterine transposition after radical trachelectomy","volume":"150","author":"Baiocchi","year":"2018","journal-title":"Gynecol Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1136\/ijgc-2020-001250","article-title":"Robotic uterine transposition for a cervical cancer patient with pelvic micrometastases after conization and pelvic lymphadenectomy","volume":"30","author":"Marques","year":"2020","journal-title":"Int J Gynecol Cancer"},{"key":"B12","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1136\/ijgc-2020-001780","article-title":"Uterine transposition for gynecological cancers","volume":"31","author":"Baiocchi","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"B13","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1136\/ijgc-2020-002074","article-title":"Uterine transposition in a pre-pubertal patient","volume":"31","author":"Vieira","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1136\/ijgc-2022-003647","article-title":"Repeated intravenous indocyanine green application to prove uterine perfusion during uterus transposition","volume":"32","author":"Kohler","year":"2022","journal-title":"Int J Gynecol Cancer"},{"key":"B15","doi-asserted-by":"publisher","first-page":"100681","DOI":"10.1016\/j.ctarc.2023.100681","article-title":"Performing a radical trachelectomy with uterine transposition in a patient with stage ib2 cervical cancer: a case report","volume":"34","author":"Chernyshova","year":"2023","journal-title":"Cancer Treat Res Commun"},{"key":"B16","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.fertnstert.2023.02.033","article-title":"First live birth after uterine transposition","author":"Ribeiro","year":"2023","journal-title":"Fertil Steril"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1136\/ijgc-2021-002944","article-title":"Uterine transposition after radical trachelectomy","volume":"31","author":"Odetto","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1136\/ijgc-2023-004661","article-title":"Uterine transposition and successful pregnancy in a patient with rectal cancer","volume":"33","author":"Lopez","year":"2023","journal-title":"Int J Gynecol Cancer"},{"key":"B19","doi-asserted-by":"publisher","first-page":"A3","DOI":"10.1136\/ijgc-2022-igcs.4","article-title":"O002\/#185 uterine transposition: feasibility study","volume":"32","author":"Ribeiro","year":"2022","journal-title":"Int J Gynecol Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1200\/JCO.2018.78.1914","article-title":"Fertility preservation in patients with cancer: asco clinical practice guideline update","volume":"36","author":"Oktay","year":"2018","journal-title":"J Clin Oncol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1159\/000449416","article-title":"Successful delivery in a 39-year-old patient with anal cancer after fertility-preserving surgery followed by primary chemoradiation and low anti-mullerian hormone level","volume":"91","author":"K\u00f6hler","year":"2016","journal-title":"Oncology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/j.fertnstert.2018.07.020","article-title":"Laparoscopic uterine fixation to spare fertility before pelvic radiation therapy","volume":"110","author":"Aza\u00efs","year":"2018","journal-title":"Fertil Steril"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmad012","article-title":"Uterus transplantation: from research, through human trials and into the future","author":"Br\u00e4nnstr\u00f6m","year":"2023","journal-title":"Hum Reprod Update"},{"key":"B24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bpobgyn.2018.12.006","article-title":"Uterus transplantation and fertility preservation","volume":"55","author":"Br\u00e4nnstr\u00f6m","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10184192","article-title":"How to protect ovarian function before and during chemotherapy?","volume":"10","author":"Arecco","year":"2021","journal-title":"J Clin Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.23736\/S0026-4784.18.04360-5","article-title":"Uterine transposition technique: update and review","volume":"71","author":"Ribeiro","year":"2019","journal-title":"Minerva Ginecol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/S0140-6736(86)92612-7","article-title":"Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision","volume":"2","author":"Quirke","year":"1986","journal-title":"Lancet"},{"key":"B28","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ygyno.2016.08.239","article-title":"Utility of indocyanine green (icg) intra-operative angiography to determine uterine vascular perfusion at the time of radical trachelectomy","volume":"143","author":"Escobar","year":"2016","journal-title":"Gynecol Oncol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ygyno.2014.04.043","article-title":"On what scale does it benefit the patients if uterine arteries were preserved during art?","volume":"134","author":"Tang","year":"2014","journal-title":"Gynecol Oncol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ygyno.2015.06.023","article-title":"Radical trachelectomy in early-stage cervical cancer: a comparison of laparotomy and minimally invasive surgery","volume":"138","author":"Vieira","year":"2015","journal-title":"Gynecol Oncol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12905-022-01887-8","article-title":"Outcomes of ovarian transposition in cervical cancer; an updated meta-analysis","volume":"22","author":"Laios","year":"2022","journal-title":"BMC Womens Health"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2024.1336047\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T04:23:35Z","timestamp":1708921415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2024.1336047\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":31,"alternative-id":["10.3389\/fsurg.2024.1336047"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2024.1336047","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"article-number":"1336047"}}