{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:29:27Z","timestamp":1787027367345,"version":"build-2736575974"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the treatment strategies for lumbar brucellar spondylitis by comparing the outcomes of pure pharmacological treatment with diseased intervertebral fixation fusion, with or without lesion clearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 157 patients with lumbar brucellar spondylitis were categorized into three groups: Group A (52 cases) received pure pharmacological treatment, Group B (53 cases) underwent posterior vertebral fixation fusion, and Group C (52 cases) received posterior (or anterior) lesion clearance followed by posterior vertebral fixation fusion. Clinical data were analyzed, and the efficacy of the three treatment methods was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The surgical groups showed better outcomes at various time points compared to the pharmacological treatment group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). The pure fixation group outperformed the lesion clearance fusion group during the perioperative period (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). The ESR, CRP, ODI scores, imaging evaluation and complications of the lesion clearance followed by fixation group were all better than those of the other two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.05). Surgical treatment groups showed no statistically significant difference in VAS scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;gt;\u20090.05), and both were superior to the pharmacological treatment group. There were no statistically significant differences in clinical efficacy among the three groups at the last follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Surgical treatment achieves early recovery goals compared to pharmacological treatment for brucellar spondylitis. However, individualized treatment principles should guide surgical decisions to select the most suitable approach for patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2024.1365498","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:42:48Z","timestamp":1711068168000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Selection of treatment strategies for lumbar Brucella spondylitis: a retrospective clinical study"],"prefix":"10.3389","volume":"11","author":[{"given":"Changhao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningkui","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.nic.2015.01.004","article-title":"Spinal brucellosis","volume":"25","author":"Tali","year":"2015","journal-title":"Neuroimaging Clin N Am"},{"key":"B2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/BRS.0000000000001697","article-title":"Comparison of tuberculous and brucellar spondylitis on magnetic resonance images","volume":"42","author":"Gao","year":"2017","journal-title":"Spine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"8903635","DOI":"10.1155\/2016\/8903635","article-title":"The evaluation of the clinical, laboratory, and radiological findings of 16 cases of brucellar spondylitis","volume":"2016","author":"Yang","year":"2016","journal-title":"Biomed Res Int"},{"key":"B4","doi-asserted-by":"publisher","first-page":"282","DOI":"10.5535\/arm.2012.36.2.282","article-title":"Back pain secondary to Brucella spondylitis in the lumbar region","volume":"36","author":"Lim","year":"2012","journal-title":"Ann Rehabil Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/s12893-022-01847-x","article-title":"One-stage posterior surgery combined with anti-Brucella therapy in the management of lumbosacral brucellosis spondylitis: a retrospective study","volume":"22","author":"Luan","year":"2022","journal-title":"BMC Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s12893-017-0279-x","article-title":"Single-stage transforaminal decompression, debridement, interbody fusion, and posterior instrumentation for lumbosacral brucellosis","volume":"17","author":"Abulizi","year":"2017","journal-title":"BMC Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/j.1469-0691.2010.03272.x","article-title":"Efficacy of prolonged antimicrobial chemotherapy for brucellar spondylodiscitis","volume":"17","author":"Ioannou","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"B8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ijid.2005.10.011","article-title":"Acute brucellosis: presentation, diagnosis, and treatment of 144 cases","volume":"11","author":"Andriopoulos","year":"2007","journal-title":"Int J Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"415","DOI":"10.14744\/nci.2019.05658","article-title":"Current therapeutic strategy in osteoarticular brucellosis","volume":"6","author":"Unuvar","year":"2019","journal-title":"North Clin Istanb"},{"key":"B10","doi-asserted-by":"publisher","first-page":"54","DOI":"10.5312\/wjo.v10.i2.54","article-title":"Osteoarticular manifestations of human brucellosis: a review","volume":"10","author":"Esmaeilnejad-Ganji","year":"2019","journal-title":"World J Orthop"},{"key":"B11","doi-asserted-by":"publisher","first-page":"107","DOI":"10.5455\/aim.2016.24.107-110","article-title":"The diagnostic value of MRI in Brucella spondylitis with comparison to clinical and laboratory findings","volume":"24","author":"Bagheri","year":"2016","journal-title":"Acta Inform Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.7326\/0003-4819-117-1-25","article-title":"Treatment of human brucellosis with doxycycline plus rifampin or doxycycline plus streptomycin. 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