{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:27:12Z","timestamp":1789597632827,"version":"build-2803163510"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of single femoral nerve block (SFNB) with 0.2% ropivacaine 50\u2005ml on postoperative pain and muscle strength in elderly patients undergoing knee replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety-four patients scheduled for primary total knee arthroplasty (TKA) were randomized into two groups. The patients in the SFNB group received SFNB with 50\u2005ml 0.2% ropivacaine (<jats:italic>n<\/jats:italic>\u2009=\u200948), while the patients in the continuous femoral nerve block (CFNB) group (<jats:italic>n<\/jats:italic>\u2009=\u200946) received CFNB with an initial load of 20\u2005ml 0.5% ropivacaine and a continuous injection of 0.2% ropivacaine at a rate of 5\u2005ml\/h. After the surgery, all patients were administered patient-controlled intravenous analgesia. The primary outcome was the visual analogue scale (VAS) score at 24\u2005h postoperatively. The secondary outcomes included: (a) Pain scores at 2\u2005h, 6\u2005h, 12\u2005h, 48\u2005h, and 72\u2005h after surgery, and the total dosage of celecoxib; (b) Muscle strength of the quadriceps at 2\u2005h, 6\u2005h, 12\u2005h, 24\u2005h, 48\u2005h, and 72\u2005h postoperatively; (c) Range of motion (ROM) at 24\u2005h, 72\u2005h, and 1 week after surgery; (d) American Knee Society knee score (AKS) at 1 week postoperatively; (e) Related complications (e.g., nausea and vomiting), and length of hospitalization; (f) General Comfort Questionnaire (GCQ) score at 72\u2005h postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(a) There were no statistically significant differences in VAS scores (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05) or the total dosage of celecoxib (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05) between the two groups at various time points; (b) The muscle strength scores in the SFNB group were higher than those in the CFNB group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05) at 6\u2005h, 12\u2005h, and 24\u2005h postoperatively; (c) Knee ROM in the SFNB group was better than in the CFNB group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05); (d) There were no significant differences in adverse events between the two groups (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05); (e) The physiological and psychological scores on the GCQ in the SFNB group were higher than those in the CFNB group (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SFNB, with 0.2% ropivacaine 50\u2005ml provides effective pain relief, and improves patient comfort after surgery, without increasing adverse effects. SFNB is a safe and convenient option for postoperative pain management following knee surgery.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2025.1403280","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:23:33Z","timestamp":1750051413000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of single femoral nerve block and continuous femoral nerve block on perioperative analgesia and muscle strength in elderly patients undergoing total knee arthroplasty, a randomized clinical 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