{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:35:29Z","timestamp":1753893329230,"version":"3.41.2"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Functional training after total knee arthroplasty (TKA) is of great significance for the recovery of knee function. However, the utility of applying an effective training modality, closed-chain isokinetic plyometric training, on top of the drug palonosetron, which is used to prevent nausea and vomiting, is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of closed-chain isokinetic plyometric training combined with palonosetron-on-postoperative-knee-function in patients with TKA, aiming to provide an effective rehabilitation program for patients with TKA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The results of the intervention were compared in 47 TKA patients who received closed-chain isokinetic plyometric training combined with palonosetron with 47 TKA patients who received conventional plyometric training combined with palonosetron. Knee function was evaluated using the Hospital for Specialty Surgery Knee (HSS), quadriceps muscle strength was assessed using real-time isometric plyometric testing with the BIODEX-sYs-tem 4-type system, walking ability was evaluated using the Timed Up-and-Go Test (TUGT), and proprioception was determined using the Biodex System 4-type multi-joint isometric system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After-the intervention,-the-HSS scores-of-the-experimental-group-were-higher-than-those-of-the-control-group-(<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05); the peak moment values of the quadriceps (PT), the total quadriceps work values (STW), and the average power of the quadriceps (AP) were higher than those of the control group (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05); and the values of the reproduced deviation of the knee joint active joint angle and the TUGT time were lower than those of the control group (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Closed-chain isokinetic plyometric training combined with palonosetron can strengthen their muscle strength and improve proprioception, which effectively promotes the recovery of postoperative knee function and walking ability in TKA patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2025.1512717","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T07:14:27Z","timestamp":1742541267000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of closed-chain isometric plyometric training combined with palonosetron on postoperative knee function in patients after total knee arthroplasty"],"prefix":"10.3389","volume":"12","author":[{"given":"Jingwen","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40634-019-0193-5","article-title":"Quadriceps muscle activity during commonly used strength training exercises shortly after total knee arthroplasty: implications for home-based exercise-selection","volume":"6","author":"Jakobsen","year":"2019","journal-title":"J Exp Orthop"},{"key":"B2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3238\/arztebl.2014.0407","article-title":"Hip and knee replacement in Germany and the USA: analysis of individual inpatient data from German and US hospitals for the years 2005 to 2011","volume":"111","author":"Wengler","year":"2014","journal-title":"Dtsch Arztebl Int"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1007\/s00167-011-1808-2","article-title":"Quadriceps femoris muscle function prior and after total knee arthroplasty in women with knee osteoarthritis","volume":"20","author":"Vahtrik","year":"2012","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"371","DOI":"10.23736\/S1973-9087.17.04712-8","article-title":"Randomized controlled trial of maximal strength training vs. standard rehabilitation following total knee arthroplasty","volume":"54","author":"Husby","year":"2018","journal-title":"Eur J Phys Rehabil Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.37190\/ABB-01771-2020-03","article-title":"Effectiveness of the power and speed dry-land training in female swimmers aged 15\u201316","volume":"23","author":"Guzik-Kopyto","year":"2021","journal-title":"Acta Bioeng Biomech"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.3390\/ijerph17134669","article-title":"Acute effects of open kinetic chain exercise versus those of closed kinetic chain exercise on quadriceps muscle thickness in healthy adults","volume":"17","author":"Cheon","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"B7","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1136\/bjsports-2018-100310","article-title":"How should clinicians rehabilitate patients after ACL reconstruction? A systematic review of clinical practice guidelines (CPGs) with a focus on quality appraisal (AGREE II)","volume":"54","author":"Andrade","year":"2020","journal-title":"Br J Sports Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3233\/BMR-201843","article-title":"Efficacy of the lumbar stabilization and thoracic mobilization exercise program on pain intensity and functional disability reduction in chronic low back pain patients with lumbar radiculopathy: a randomized controlled trial","volume":"33","author":"Kostadinovi\u0107","year":"2020","journal-title":"J Back Musculoskelet Rehabil"},{"key":"B9","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1123\/jsr.2019-0397","article-title":"Comparison of the graston technique\u00ae with instrument-assisted soft tissue mobilization for increasing dorsiflexion range of motion","volume":"30","author":"Bush","year":"2020","journal-title":"J Sport Rehabil"},{"key":"B10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ptsp.2024.01.009","article-title":"Intrinsic graft laxity variation with open kinetic chain exercise after anterior cruciate ligament reconstruction: a non-randomized controlled study","volume":"66","author":"Forelli","year":"2024","journal-title":"Phys Ther Sport."},{"key":"B11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/01.rhu.0000191213.37853.3d","article-title":"Effects of kinesthesia and balance exercises in knee osteoarthritis","volume":"11","author":"Diracoglu","year":"2005","journal-title":"J Clin Rheumatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1007\/s11999-010-1357-x","article-title":"Antiemesis after total joint arthroplasty: does a single preoperative dose of aprepitant reduce nausea and vomiting?","volume":"468","author":"DiIorio","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/j.1365-2710.2009.01141.x","article-title":"Methylprednisolone reduces postoperative nausea in total knee and hip arthroplasty","volume":"35","author":"Miyagawa","year":"2010","journal-title":"J Clin Pharm Ther"},{"key":"B14","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13063-023-07884-y","article-title":"Optimizing the use of ketamine to reduce chronic postsurgical pain in women undergoing mastectomy for oncologic indication: study protocol for the KALPAS multicenter randomized controlled trial","volume":"25","author":"Wang","year":"2024","journal-title":"Trials"},{"key":"B15","doi-asserted-by":"publisher","first-page":"517","DOI":"10.4097\/kjae.2013.64.6.517","article-title":"Palonosetron has superior prophylactic antiemetic efficacy compared with ondansetron or ramosetron in high-risk patients undergoing laparoscopic surgery: a prospective, randomized, double-blinded study","volume":"64","author":"Kim","year":"2013","journal-title":"Korean J Anesthesiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fmed.2015.00087","article-title":"Alternative therapies for the prevention of postoperative nausea and vomiting","volume":"2","author":"Stoicea","year":"2015","journal-title":"Front Med (Lausanne)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e0196388","DOI":"10.1371\/journal.pone.0196388","article-title":"Effects of palonosetron for prophylaxis of postoperative nausea and vomiting in high-risk patients undergoing total knee arthroplasty: a prospective, randomized, double-blind, placebo-controlled study","volume":"13","author":"Ryu","year":"2018","journal-title":"PLoS One."},{"key":"B18","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1055\/s-0040-1721423","article-title":"Total knee arthroplasty after anterior cruciate ligament reconstruction","volume":"35","author":"Best","year":"2022","journal-title":"J Knee Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1186\/s13063-017-2173-3","article-title":"Effectiveness of an interactive telerehabilitation system with home-based exercise training in patients after total hip or knee replacement: study protocol for a multicenter, superiority, no-blinded randomized controlled trial","volume":"18","author":"Eichler","year":"2017","journal-title":"Trials"},{"key":"B20","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ocl.2020.02.009","article-title":"Minimally invasive total knee arthroplasty: does surgical technique actually impact the outcome?","volume":"51","author":"Mora","year":"2020","journal-title":"Orthop Clin North Am."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.12200\/j.issn.1003-0034.2023.12.010","article-title":"Clinical observation of virtual reality technology combined with isokinetic strength training for patients after anterior cruciate ligament reconstruction","volume":"36","author":"Lu","year":"2023","journal-title":"China J Orthop Traumatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"10529","DOI":"10.1038\/s41598-020-67613-2","article-title":"Approximating the maximum tibial coverage in total knee arthroplasty does not necessarily result in implant malrotation","volume":"10","author":"Shao","year":"2020","journal-title":"Sci Rep"},{"key":"B23","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s13063-022-06153-8","article-title":"Comparison of the open kinetic chain and closed kinetic chain strengthening exercises on pain perception and lower limb biomechanics of patients with mild knee osteoarthritis: a randomized controlled trial protocol","volume":"23","author":"Ng","year":"2022","journal-title":"Trials"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1002\/acr.24028","article-title":"Racial disparities in total knee replacement failure as related to poverty","volume":"71","author":"Bass","year":"2019","journal-title":"Arthritis Care Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"695.11","DOI":"10.4081\/ejtm.2022.10416","article-title":"Enhanced strength, power, work capacity, and fatigue resistance in high intensity functional training athletes","volume":"33","author":"Coletti","year":"2019","journal-title":"FASEB J."},{"key":"B26","first-page":"74","article-title":"Effects of balance training under visual feedback on balance and walking ability of patients after total knee arthroplasty","volume":"27","author":"Wang","year":"2023","journal-title":"J Pract Clin Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"23259671231177594","DOI":"10.1177\/23259671231177594","article-title":"Evaluation of muscle strength and graft laxity with early open kinetic chain exercise after ACL reconstruction: a cohort study","volume":"11","author":"Forelli","year":"2023","journal-title":"Orthop J Sports Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e20230164","DOI":"10.1590\/1806-9282.20230164","article-title":"Effects of closed and open kinetic chain exercises on pain, muscle strength, function, and quality of life in patients with knee osteoarthritis","volume":"69","author":"\u00d6z\u00fcdo\u011fru","year":"2023","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e13589","DOI":"10.7717\/peerj.13589","article-title":"Electromyographic analysis of the serratus anterior and upper trapezius in closed kinetic chain exercises performed on different unstable support surfaces: a systematic review and meta-analysis","volume":"10","author":"Mendez-Rebolledo","year":"2022","journal-title":"PeerJ"},{"key":"B30","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1589\/jpts.35.379","article-title":"Influences of trunk stability on exercise performance of closed kinetic chain of upper and lower limbs","volume":"35","author":"Horii","year":"2023","journal-title":"J Phys Ther Sci"},{"key":"B31","doi-asserted-by":"publisher","first-page":"103766","DOI":"10.1016\/j.medengphy.2022.103766","article-title":"In vivo tibiofemoral kinematics of the normal knee during closed and open kinetic chain exercises: a comparative study of box squat and seated knee extension","volume":"101","author":"Li","year":"2022","journal-title":"Med Eng Phys"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2025.1512717\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T15:41:31Z","timestamp":1742830891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2025.1512717\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":31,"alternative-id":["10.3389\/fsurg.2025.1512717"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2025.1512717","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"article-number":"1512717"}}