{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:12:52Z","timestamp":1790932372872,"version":"4.1.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This meta-analysis aimed to estimate the prevalence and identify risk factors for conversion to laparotomy during laparoscopic hysterectomy (LH) for both benign and malignant gynecologic conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive search of PubMed, Embase, and the Cochrane Library was conducted to identify studies published between January 2000 and September 2024. Eligible studies reported the prevalence and risk factors for conversion to laparotomy in patients undergoing LH. Studies were assessed for quality using the Newcastle-Ottawa Scale (NOS), and data were extracted on patient demographics, surgical details, and outcomes. A random-effects model was used to pool prevalence estimates and analyze risk factors. Heterogeneity was assessed using the I<jats:sup>2<\/jats:sup> statistic, and publication bias was evaluated with funnel plots and Egger's test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 12 studies, encompassing 12,785 patients, were included. The pooled prevalence of conversion to laparotomy was 6% (95% CI, 5%\u20137%), with significant heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200991.8%, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). Conversion rates were higher in patients with malignant conditions (11%; 95% CI, 9%\u201314%) compared to benign conditions (5%; 95% CI, 4%\u20136%). Key risk factors included a history of adhesions (OR, 3.13; 95% CI, 1.91\u20135.11) and higher BMI (OR, 1.20; 95% CI, 1.08\u20131.34). Protective factors included surgeon experience (OR, 0.22; 95% CI, 0.08\u20130.59) and high surgeon volume (OR, 0.57; 95% CI, 0.34\u20130.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Conversion to laparotomy occurs in approximately 6% of LH cases, particularly in patients with malignancy, a history of adhesions, or higher BMI. Surgeon expertise and case volume may reduce the risk, highlighting the importance of preoperative risk assessment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2025.1522022","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T05:25:53Z","timestamp":1746509153000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Conversion to laparotomy during laparoscopic hysterectomy: a meta-analysis of prevalence and key risk factors"],"prefix":"10.3389","volume":"12","author":[{"given":"Qing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1001\/jama.2013.186","article-title":"Robotically assisted vs laparoscopic hysterectomy among women with benign gynecologic disease","volume":"309","author":"Wright","year":"2013","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1200\/jco.2011.36.7508","article-title":"Comparative effectiveness of robotic versus laparoscopic hysterectomy for endometrial cancer","volume":"30","author":"Wright","year":"2012","journal-title":"J Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12957-023-03044-3","article-title":"Effect of modified radical laparoscopic hysterectomy versus open radical hysterectomy on short-term clinical outcomes in early-stage cervical cancer: a single-center, prospective, randomized controlled trial","volume":"21","author":"Lv","year":"2023","journal-title":"World J Surg Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1097\/aog.0000000000005434","article-title":"Vaginal hysterectomy compared with laparoscopic hysterectomy in benign gynecologic conditions: a systematic review and meta-analysis","volume":"142","author":"Azadi","year":"2023","journal-title":"Obstet Gynecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"185","DOI":"10.52054\/fvvo.16.2.020","article-title":"Predictive factors for conversion to laparotomy in women undergoing laparoscopic hysterectomy. 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