{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:34:35Z","timestamp":1753893275325,"version":"3.41.2"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>On August 28th, 2023, a 13-year-old male was diagnosed with conventional osteosarcoma of the proximal left tibia after a needle biopsy. Subsequently, the patient received two cycles of neoadjuvant chemotherapy and four cycles of postoperative chemotherapy. On December 27, 2023, the tumor resection was performed while preserving the knee joint, which involved inactivation of the tumor-bearing bone, autologous bilateral fibula grafting, and fixation of the grafted bone to the host bone using plate and screws. Follow-up after surgery included x-rays and CT scans. On February 28, 2024, two months after the surgery, new bone formation was noted at the site from which bone was harvested from the right fibula, the left knee joint had satisfactory range of motion in flexion (130\u00b0) and extension (0\u00b0). Additionally, partial healing of both the grafted bone and the host bone was observed. In the follow-up on September 23rd, 2024, nine months post-operation, the right fibula had reformed. Furthermore, the transplanted and host bones of the left tibia had healed securely. It was confirmed that there was no recurrence or metastasis of the tumor during the last follow-up by ECT. This case highlights the feasibility and effectiveness of using inactivating tumor-bearing bone and autologous bilateral fibular grafting to repair large bone defects after joint-sparing surgery for malignant tumors near the joints.<\/jats:p>","DOI":"10.3389\/fsurg.2025.1544336","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T05:24:46Z","timestamp":1745904286000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Application of tumor-bearing bone inactivation and bilateral fibula grafting in joint-sparing surgery for osteosarcoma patient"],"prefix":"10.3389","volume":"12","author":[{"given":"Yapeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2019en","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3390\/bioengineering9110680","article-title":"3D-printing For critical sized bone defects: current concepts and future directions","volume":"9","author":"Mayfield","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1245\/s10434-022-12788-3","article-title":"Functional outcome following proximal tibial osteosarcoma resection and reconstruction by modular endoprosthesis","volume":"30","author":"Ebeid","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s11999-014-4028-5","article-title":"Survival, recurrence, and function after epiphyseal preservation and allograft reconstruction in osteosarcoma of the knee","volume":"473","author":"Aponte-Tinao","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e33237","DOI":"10.1097\/MD.0000000000033237","article-title":"Follow-up of biological reconstruction of epiphysis preserving osteosarcoma around the knee in children: a retrospective cohort study","volume":"102","author":"Dai","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1097\/CORR.0000000000003007","article-title":"Intercalary resection of the tibia for primary bone tumors: are vascularized fibula autografts with or without allografts a durable reconstruction?","volume":"482","author":"Campanacci","year":"2024","journal-title":"Clin Orthop Relat Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"100224","DOI":"10.1016\/j.jbo.2019.100224","article-title":"Bone transport using the Ilizarov method for osteosarcoma patients with tumor resection and neoadjuvant chemotherapy","volume":"16","author":"Wang","year":"2019","journal-title":"J Bone Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1007\/s11999-016-4843-y","article-title":"Proximal tibia reconstruction after bone tumor resection: are survivorship and outcomes of endoprosthetic replacement and osteoarticular allograft similar?","volume":"475","author":"Albergo","year":"2017","journal-title":"Clin Orthop Relat Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1097\/CORR.0000000000002720","article-title":"What are the complications, function, and survival of tumor-devitalized autografts used in patients with limb-sparing surgery for bone and soft tissue tumors? A Japanese musculoskeletal oncology group multi-institutional study","volume":"481","author":"Takeuchi","year":"2023","journal-title":"Clin Orthop Relat Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s10195-019-0527-1","article-title":"Ilizarov bone transport and treatment of critical-sized tibial bone defects: a narrative review","volume":"20","author":"Aktuglu","year":"2019","journal-title":"J Orthop Traumatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1186\/s12891-023-06955-0","article-title":"Complications analysis of Ilizarov bone transport technique in the treatment of tibial bone defects-a retrospective study of 199 cases","volume":"24","author":"Feng","year":"2023","journal-title":"BMC Musculoskelet Disord"},{"key":"B11","doi-asserted-by":"publisher","first-page":"E920","DOI":"10.1503\/cmaj.200005","article-title":"Periosteum preservation in bone regeneration","volume":"192","author":"Colangeli","year":"2020","journal-title":"CMAJ"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2025.1544336\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T05:24:47Z","timestamp":1745904287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2025.1544336\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":11,"alternative-id":["10.3389\/fsurg.2025.1544336"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2025.1544336","relation":{},"ISSN":["2296-875X"],"issn-type":[{"type":"electronic","value":"2296-875X"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"article-number":"1544336"}}