{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:07:42Z","timestamp":1758701262949,"version":"3.44.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Epithelioid hemangioendothelioma (EHE) is a rare and locally aggressive tumour of vascular endothelial origin, with an estimated prevalence of less than 1 in a million. EHE can arise in any part of the body, most commonly in the liver, lungs, and skeleton, while occurrence in the blood vessels of the extremities is rare. This article reports a rare case of primary epithelioid hemangioendothelioma (EHE) of the right femoral artery. The patient was initially misdiagnosed with lower limb arterial occlusion and treated with stenting and other therapies; however, symptoms recurred, and the diagnosis of EHE was confirmed by pathological biopsy. EHE is very rare and accounts for approximately 1% of all vascular tumours. Based on pathological findings\u2014 CD31(+), CD34(\u2212), CAMTA(+)\u2013our patient was diagnosed with WWTR1-CAMTA1 fusion EHE.Treatment of EHE is mainly surgical. In our case, the patient underwent resection of the lesion area and the surrounding soft tissue mass, followed by a reconstruction using a left saphenous vein graft.<\/jats:p>","DOI":"10.3389\/fsurg.2025.1582444","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T05:34:14Z","timestamp":1755149654000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A case of epithelioid hemangioendothelioma of the right femoral artery misdiagnosed as arterial occlusion"],"prefix":"10.3389","volume":"12","author":[{"given":"Zhengqi","family":"Shao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BaiChuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HongZhi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.path.2018.10.002","article-title":"The molecular diagnostics of vascular neoplasms","volume":"12","author":"Habeeb","year":"2019","journal-title":"Surg Pathol Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"563.e13","DOI":"10.1016\/j.avsg.2020.02.028","article-title":"Epithelioid hemangioendothelioma of the ulnar artery presenting with neuropathy","volume":"67","author":"Alam","year":"2020","journal-title":"Ann Vasc Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2349991","DOI":"10.1155\/2022\/2349991","article-title":"Epithelioid hemangioendothelioma: incidence, mortality, prognostic factors, and survival analysis using the Surveillance, Epidemiology, and End Results database","volume":"2022","author":"Liu","year":"2022","journal-title":"J Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1093\/jjco\/hyae037","article-title":"Epithelioid hemangioendothelioma\u2014its history, clinical features, molecular biology and current therapy","volume":"54","author":"Tsuchihashi","year":"2024","journal-title":"Jpn J Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1038\/modpathol.2013.176","article-title":"Malignant vascular tumors\u2013an update","volume":"27","author":"Antonescu","year":"2014","journal-title":"Mod Pathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.32074\/1591-951X-213","article-title":"The 2020 WHO classification of soft tissue tumours: news and perspectives","volume":"113","author":"Sbaraglia","year":"2021","journal-title":"Pathologica"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1378\/chest.11-0039","article-title":"Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer","volume":"140","author":"Lau","year":"2011","journal-title":"Chest"},{"key":"B8","doi-asserted-by":"publisher","first-page":"665.e1","DOI":"10.1016\/j.avsg.2020.10.017","article-title":"Epithelioid hemangioendothelioma of the lower limb, discovered by a claudication","volume":"72","author":"Yven","year":"2021","journal-title":"Ann Vasc Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"100170","DOI":"10.1016\/j.esmoop.2021.100170","article-title":"Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts","volume":"6","author":"Stacchiotti","year":"2021","journal-title":"ESMO Open"},{"key":"B10","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/PAP.0000000000000284","article-title":"The 2020 WHO classification of tumors of soft tissue: selected changes and new entities","volume":"28","author":"Choi","year":"2021","journal-title":"Adv Anat Pathol"},{"key":"B11","first-page":"259","article-title":"Epithelioid hemangioendothelioma and related lesions","volume":"3","author":"Weiss","year":"1986","journal-title":"Semin Diagn Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/PAS.0000000000000511","article-title":"Nuclear expression of CAMTA1 distinguishes epithelioid hemangioendothelioma from histologic mimics","volume":"40","author":"Doyle","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1097\/00000478-198510000-00001","article-title":"Malignant epithelioid hemangioendothelioma of the liver in young women. 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