{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T15:22:41Z","timestamp":1754148161457,"version":"3.41.2"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UC-OGCP) is an exceedingly rare malignant tumour that accounts for less than 1% of all pancreatic nonendocrine neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We present a case of UC-OGCP in a 46-year-old male patient who was referred to our hospital after the incidental identification of a cystic tumour in the pancreas. Computed tomography (CT) revealed a 1.4\u2009\u00d7\u20091.4\u2009\u00d7\u20091.6-cm mass in the pancreatic head. Surgical resection was performed because it was difficult to determine the degree of malignancy of the tumour through clinical assessment. Intraoperative frozen-section pathology confirmed that the tumour was a malignant neoplasm. Pancreaticoduodenectomy was subsequently conducted. Histopathological studies confirmed the diagnosis of UC-OGCP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical symptoms of UC-OGCP are nonspecific, and there are no distinct serological markers. Diagnosis relies primarily on endoscopic biopsy or postoperative pathology. We report this case of UC-OGCP and provide a literature review on the clinicopathological features, differential diagnosis, treatment, and prognosis of UC-OGCP, aiming to improve the understanding of this disease.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2025.1584200","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T13:56:04Z","timestamp":1752846964000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a rare case report and review of the literature"],"prefix":"10.3389","volume":"12","author":[{"given":"Lu","family":"Si","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuwen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.14701\/ahbps.23-161","article-title":"Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: an individual participant data meta-analysis","volume":"28","author":"Mylonakis","year":"2024","journal-title":"Ann Hepatobiliary Pancreat Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"109419","DOI":"10.1016\/j.ijscr.2024.109419","article-title":"Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, a two cases report","volume":"116","author":"Tambasco","year":"2024","journal-title":"Int J Surg Case Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1409197","DOI":"10.3389\/fonc.2024.1409197","article-title":"Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a narrative review","volume":"14","author":"Wu","year":"2024","journal-title":"Front Oncol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/1097-0142(196808)22:2%3C333::AID-CNCR2820220210%3E3.0.CO;2-A","article-title":"Carcinoma of pancreas simulating giant cell tumor of bone. 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