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Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the longstanding awareness of the increasing incidence and consequences of periprosthetic proximal femoral fractures (PPFFs), and the rationale protective role of the preserved bone stock, no method for its evaluation, with the potential for routine clinical application, has been available. A novel method for the evaluation of preserved proximal femoral bone stock volume (<jats:italic>V<\/jats:italic><jats:sub>PF<\/jats:sub>) in conventional primary total hip arthroplasty (THA) on routinely available hip radiographs was introduced and compared with clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study was designed according to the standard protocol for retrospective matched case-control research. 30 cases of late PPFFs (minimum 1 year postoperatively) were identified in the hospital database of all implanted Anatomic Benoist Girard (ABG) II femoral stems. For every case, 2 age-\/sex-\/implant size-\/surgeon-matched controls were found. The <jats:italic>V<\/jats:italic><jats:sub>PF<\/jats:sub> was evaluated for each hip, and the mean values in both groups were compared. The accuracy and intra-\/inter-rater reliability of the novel method were tested. Regression subanalyses were performed to identify factors influencing the risk of PPFFs, and to assess correlations between <jats:italic>V<jats:sub>PF<\/jats:sub><\/jats:italic> and other covariables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:italic>V<jats:sub>PF<\/jats:sub><\/jats:italic> in the group of cases was 113.8\u2009\u00b1\u200921.0\u2005cm<jats:sup>3<\/jats:sup> and significantly lower compared to 164.0\u2009\u00b1\u200938.4\u2005cm<jats:sup>3<\/jats:sup> in the control group (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.01). The method's reliability and accuracy were within good to excellent range. The <jats:italic>V<\/jats:italic><jats:sub>PF<\/jats:sub> was the sole significant factor influencing the risk of PPFFs (aOR\u2009=\u20090.92). The cut-off value was determined at 128.5\u2005cm<jats:sup>3<\/jats:sup>. The regression analysis indicated an interplay of intuitively connected factors in the long-term PPFFs prognosis (<jats:italic>V<\/jats:italic><jats:sub>PF<\/jats:sub>, stress shielding, subsidence).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presented results indicate that bone stock preservation (with <jats:italic>V<jats:sub>PF<\/jats:sub><\/jats:italic> as a quantitative measure) is crucial for the prevention of late PPFFs.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2025.1659027","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T05:26:24Z","timestamp":1760419584000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Low preserved proximal femoral bone stock volume as a risk factor for periprosthetic femoral fractures. 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