{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:18:39Z","timestamp":1760055519223,"version":"build-2065373602"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lu'an Science and Technology Plan Project","award":["2022lakj040"],"award-info":[{"award-number":["2022lakj040"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A gastric hamartomatous inverted polyp (GHIP) is an uncommon submucosal neoplasm that is histopathologically defined by a submucosal inverted growth of cystically dilated hyperplastic gastric glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 74-year-old Chinese man presented with a submucosal tumor (SMT) in the cardia, identified through electronic gastroscopy. This report presents a case of cardia hamartomatous inverted polyp (CHIP), which represent a rare histological variant of gastric polyps that pose diagnostic challenges. The endoscopic examination revealed the presence of a submucosal tumor, and endoscopic ultrasonography indicated a heterogeneous tumor predominantly situated within the third (submucosal) layer. Immunohistochemistry outcomes indicated MUC5AC (+), MUC6 (+), Syn (+), Ki-67 (+, approximately 5%), Desmin (+), SMA (+), as well as MUC2 (\u2212). To achieve <jats:italic>en bloc<\/jats:italic> resection for lesions &amp;gt;1.0\u2005cm, endoscopic submucosal dissection (ESD) was performed. The pathological evaluation confirmed the diagnosis of CHIP. The patient was discharged without experiencing any complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, the ESD approach may be particularly suitable for the management of SMT-type hamartomatous inverted polyps.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fsurg.2025.1682095","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:27:08Z","timestamp":1759987628000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The successful management of a cardia hamartomatous inverted polyp via endoscopic submucosal dissection: a case report"],"prefix":"10.3389","volume":"12","author":[{"given":"Xu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-nian","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"B1","first-page":"380","article-title":"Cystic \u201chamartomatous\u201d epithelial polyps of the stomach","volume":"25","author":"Sipponen","year":"1978","journal-title":"Acta Hepatogastroenterol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s00595-004-2761-1","article-title":"Diagnosis and treatment of a gastric hamartomatous inverted polyp: report of a case","volume":"34","author":"Aoki","year":"2004","journal-title":"Surg Today"},{"key":"B3","doi-asserted-by":"publisher","first-page":"568","DOI":"10.5946\/ce.2013.46.5.568","article-title":"A case of gastric inverted hyperplastic polyp found with gastritis cystica profunda and early gastric cancer","volume":"46","author":"Lee","year":"2013","journal-title":"Clin Endosc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1034\/j.1600-0463.2002.1101005.x","article-title":"Gastric inverted hyperplastic polyp. 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