{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:38:22Z","timestamp":1788903502087,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perioperative neurocognitive disorder (PND) represents a significant impediment to postoperative recovery in patients undergoing colorectal cancer surgery, particularly among the elderly. This systematic review synthesizes contemporary evidence on PND incidence, risk stratification, and prophylactic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adhering to PRISMA guidelines, 343 records were identified from PubMed, Embase, and Web of Science. Bibliometric profiling delineated influential journals, institutions, and seminal references. Following deduplication and screening, 11 randomized controlled trials (RCTs) met inclusion criteria for systematic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Bibliometric analysis revealed Journal of Geriatric Oncology (impact factor 2.7) and Amphia Hospital (Netherlands) as top contributors. PND incidence ranged from 3.4% to 56% across studies. Key risk factors included advanced age (mean 63\u201376 years), ASA status II\u2013III, and open surgery. Prophylactic interventions reduced PND: melatonin decreased POD by 20%; dexmedetomidine reduced PND by 10.8%\u201325%. Fast-track surgery lowered POD by 9.5%. Mechanistically, effective strategies attenuated neuroinflammation (IL-6\/TNF-\u03b1 reduction) and optimized analgesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multimodal interventions\u2014especially dexmedetomidine-enhanced analgesia and fast-track protocols\u2014consistently mitigate PND. Standardization of PND assessment tools and diversification of study populations are urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2025.1698597","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T06:22:39Z","timestamp":1763446959000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Perioperative neurocognitive disorder in colorectal cancer surgery: a systematic review of incidence, mechanisms, and 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