{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:45:01Z","timestamp":1764225901135,"version":"3.46.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The interhemispheric transcallosal (ITA) and endoscopic approaches (EA) are established treatments for third ventricle colloid cysts (TVCCs); however, their relative parenchymal impact and the progression of associated MRI changes from early to late postoperative stages remain undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare early volumetric MRI findings after ITA and EA for TVCC resection and determine whether early parenchymal injury persisted on late imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-three patients (ITA, 13; EA, 10) with early and late postoperative MRI were retrospectively reviewed. Early T2\/FLAIR hyperintensity volumes were segmented along the surgical tract (burr-hole tract subtracted in EA). DWI\/ADC imaging assessed diffusion restriction. Late MRI evaluated gliosis, encephalomalacia, and parenchymal loss. Statistical, correlation, and sensitivity analyses assessed associations while adjusting for cyst size and hydrocephalus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Early MRI hyperintensity volume was smaller after ITA than EA (349\u2009\u00b1\u2009218\u2005mm\n                      <jats:sup>3<\/jats:sup>\n                      vs. 2,952\u2009\u00b1\u20092,084\u2005mm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). Diffusion restriction occurred in 7.7% of ITA and 50% of EA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.052). Gliosis, encephalomalacia, and parenchymal loss on late MRI were absent after ITA but present in 50% of EA cases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007 each), with larger early volumes in EA associated with gliosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), encephalomalacia, and parenchymal loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016 each). These associations persisted after adjusting for cyst size and hydrocephalus. Gross total resection occurred in 92% of ITA and 50% of EA cases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with ITA, EA produced larger early parenchymal injury, half of which persisted as structural abnormalities on late imaging, indicating more persistent radiologic change.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2025.1698632","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:31:34Z","timestamp":1764225094000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative MRI comparison of early and late parenchymal injury after transcallosal vs. endoscopic approaches for third ventricle colloid 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Erdem","family":"Ak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdurrahman","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Keles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burak","family":"Ozaydin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa K.","family":"Baskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.surneu.2007.11.005","article-title":"Microsurgical treatment of third ventricular colloid cysts by interhemispheric far lateral transcallosal approach--experience of 134 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