{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:15:21Z","timestamp":1770880521016,"version":"3.50.1"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:p>Myofibroblastic sarcomas of the breast are rare, leading to very few reports on their prognosis and metastasis potential. We report a case of lung metastasis from a mammary low-grade myofibroblastic sarcoma. A 55-year-old woman with no remarkable past medical history presented to a local clinic with a palpable mass in her left breast that had persisted for 3 weeks. Vacuum-assisted excisional biopsy initially suggested a diagnosis of a malignant phyllodes tumor. Subsequent wide excision with clear surgical margins led to a confirmed diagnosis of myofibroblastic sarcoma. No additional treatments, such as chemotherapy or radiotherapy, were administered. Four years later, lung metastases were detected on chest computed tomography. The patient subsequently underwent wedge resection of the lung. Three years later, metastasis to the cervical lymph nodes was discovered. Owing to tumor emboli, the patient ultimately died from brain infarction. No consensus guidelines for standard treatment exist due to the scarcity of the disease. Although surgical resection remains the most reasonable treatment option, additional therapies should be considered to reduce the risk of metastatic spread to other organs.<\/jats:p>","DOI":"10.3389\/fsurg.2025.1698795","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T06:46:18Z","timestamp":1770878778000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mammary myofibroblastic sarcoma with lung metastasis: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Miri","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn Joo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Kyung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meehyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Jin","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyeon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Yul Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine","place":["Gyeongnam, Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.4048\/jbc.2023.26.e36","article-title":"A radiation induced low-grade myofibroblastic sarcoma in the retropectoral area after breast conserving surgery: a case report","volume":"26","author":"Park","year":"2023","journal-title":"J Breast Cancer"},{"key":"B2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/lary.26146","article-title":"Low-grade myofibroblastic sarcoma: a population-based study","volume":"127","author":"Chan","year":"2017","journal-title":"Laryngoscope"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1097\/00000478-199810000-00008","article-title":"Low-grade myofibroblastic sarcoma: analysis of 18 cases in the spectrum of myofibroblastic tumors","volume":"22","author":"Mentzel","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6249","DOI":"10.1200\/JCO.2005.06.213","article-title":"Uncommon malignancies\u2014case 1. Low-grade myofibroblastic sarcoma of the breast","volume":"23","author":"Morgan","year":"2005","journal-title":"J Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12880-018-0287-z","article-title":"Low-grade myofibroblastic sarcoma: clinical and imaging findings","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Med Imaging"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1366546","DOI":"10.3389\/fonc.2024.1366546","article-title":"Myofibroblastic sarcoma in breast: a case report and literature review","volume":"14","author":"Deng","year":"2024","journal-title":"Front Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1097\/00000478-198707000-00001","article-title":"Myofibroblastoma of the breast. Sixteen cases of a distinctive benign mesenchymal tumor","volume":"11","author":"Wargotz","year":"1987","journal-title":"Am J Surg Pathol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.32074\/1591-951X-213","article-title":"The 2020 WHO classification of soft tissue tumours: news and perspectives","volume":"113","author":"Sbaraglia","year":"2021","journal-title":"Pathologica"},{"key":"B9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3892\/ol.2014.2790","article-title":"Low-grade myofibroblastic sarcomas of the maxilla","volume":"9","author":"Qiu","year":"2015","journal-title":"Oncol Lett"},{"key":"B10","first-page":"573","article-title":"Effective treatment of low-grade myofibroblastic sarcoma with apatinib: a case report and literature review","volume":"15","author":"Lin","year":"2022","journal-title":"Pharmgenomics Pers Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e31715","DOI":"10.1097\/MD.0000000000031715","article-title":"Low-grade myofibroblastic sarcoma of the proximal femur: a case report and literature review","volume":"101","author":"Gao","year":"2022","journal-title":"Medicine (Baltimore)"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2025.1698795\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T06:46:19Z","timestamp":1770878779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2025.1698795\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":11,"alternative-id":["10.3389\/fsurg.2025.1698795"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2025.1698795","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"article-number":"1698795"}}