{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:31:14Z","timestamp":1764657074713,"version":"3.46.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cervical disc herniation at the C2-3 level, resulting in cervical spondylotic myelopathy (CSM), is an uncommon clinical entity. The diagnostic and therapeutic complexity escalates when this pathology coexists with non-contiguous multilevel cervical disc degenerative disease (CDDD). Due to the segmental variability in pathological features, the clinical manifestations of such cases are highly heterogeneous, thereby necessitating a highly individualized treatment strategy. Hybrid surgery (HS), which integrates cervical disc arthroplasty (CDA) and anterior cervical discectomy and fusion (ACDF), offers a tailored approach for the management of multilevel degenerative cervical pathology. The unique anatomical features and surgical technical challenges at the C2-3 level impose significant constraints on treatment options. This article presents a case of non-contiguous three-level hybrid surgery involving CDA at C2-3 and ACDF at C4-5 and C5-6, and discusses the feasibility of this technique for upper cervical disc pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 62-year-old female was admitted with a 6-month history of neck and right upper limb pain, numbness, and gait instability, which had been unresponsive to conservative management. DR revealed loss of the normal cervical lordosis. CT showed no significant osteophyte formation or bony canal stenosis. MRI demonstrated a large disc extrusion at C2-3 causing spinal cord compression, and disc herniations at C4-5 and C5-6 with nerve root impingement. Based on clinical and imaging findings, a diagnosis of multilevel cervical spondylopathy (C2-3, C4-5, and C5-6 disc herniation) was established. The patient underwent anterior cervical discectomy followed by artificial disc arthroplasty (CDA) at C2-3, and anterior cervical discectomy and fusion (ACDF) at C4-5 and C5-6, successfully completing a non-contiguous three-level hybrid surgical procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Postoperative symptoms were significantly alleviated. At the 12-month follow-up, pain and gait disturbance had largely returned to normal. MRI confirmed adequate decompression of neural compression, DR demonstrated satisfactory range of motion (ROM) at C2-3, and CT revealed satisfactory bone healing at the fused segments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CDA serves as an effective alternative for C2-3 disc pathology, achieving neural decompression while preserving segmental mobility. The HS provides a valuable surgical option for the precise treatment of non-contiguous multilevel degenerative disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2025.1706862","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:27:42Z","timestamp":1764656862000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-contiguous three-level hybrid surgery with C2-3 cervical disc arthroplasty: a case report and literature review"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiaoqiang","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghe","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingkui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangkang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3171\/2021.7.SPINE21478","article-title":"Hybrid surgery: a comparison of early postoperative outcomes between anterior cervical discectomy and fusion and cervical disc arthroplasty","volume":"36","author":"Michalopoulos","year":"2022","journal-title":"J Neurosurg Spine"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1097\/BRS.0b013e31819c9d39","article-title":"Artificial disc replacement combined with fusion versus two-level fusion in cervical two-level disc disease","volume":"34","author":"Shin","year":"2009","journal-title":"Spine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jocn.2017.02.030","article-title":"Clinical and radiographic features of hybrid surgery for the treatment of skip-level cervical degenerative disc disease: a minimum 24-month follow-up","volume":"40","author":"Wu","year":"2017","journal-title":"J Clin Neurosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13018-023-03537-7","article-title":"Biomechanical effects of hybrid constructions in the treatment of noncontinuous cervical spondylopathy: a finite element analysis","volume":"18","author":"Sun","year":"2023","journal-title":"J Orthop Surg Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1345319","DOI":"10.3389\/fbioe.2024.1345319","article-title":"Segment selection for fusion and artificial disc replacement in the hybrid surgical treatment of noncontiguous cervical spondylosis: a finite element analysis","volume":"12","author":"Sun","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.3389\/fbioe.2020.00154","article-title":"Optimization of three-level cervical hybrid surgery to prevent adjacent segment disease: a finite element study","volume":"8","author":"Wong","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3171\/spi.2004.100.3.0303","article-title":"High cervical disc herniation presenting with C-2 radiculopathy - 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