{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:51:27Z","timestamp":1772632287676,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the characteristics and research hotspots of perianal lesions associated with Crohn's disease (CD) based on the currently published literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive search of all relevant literature on \u201cCrohn's disease\u201d and \u201cPerianal\u201d from the inception of PubMed, Web of Science Core Collection and Scopus database up to December 31, 2024. Using the bibliometric analysis software CiteSpace 6.4. R1, we visualized and scientifically interpreted the authors, countries, and keywords of the included studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4,286 papers were retrieved using the subject terms \u201cCrohn's disease\u201d and \u201cPerianal\u201d. According to exclusion criteria, 2,134 papers were included in the final analysis. These studies involved 130 researchers, 360 research institutions, and 148 keywords. The analysis revealed that the number of publications on CD with perianal lesions has increased annually since 1979, indicating growing attention to this condition. The United States led in the number of publications, with 452 related papers. The most prolific authors were Ye, Byong Duk and Lightner, Amy L, with 21 published papers each on the topic. The top five keywords were Crohn's disease (357 times), Inflammatory Bowel Disease (202 times), Perianal Fistula (110 times), Ulcerative Colitis (81 times), and Perianal Disease (37 times).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current research on CD with perianal lesions is primarily focused on mesenchymal stem cells, intestinal inflammation, and biologic therapies. However, further comprehensive studies are needed to improve the early diagnosis and treatment of CD, particularly when perianal symptoms are the initial manifestation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1624488","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:58:28Z","timestamp":1772607508000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of the current status of research on perianal lesions associated with Crohn's disease: a bibliometric and visualization analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Pengfei","family":"Zhou","sequence":"first","affiliation":[{"name":"Anorectal Department, The First Affiliated Hospital of Henan University of CM","place":["Zhengzhou, Henan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingen","family":"Lu","sequence":"additional","affiliation":[{"name":"Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Fu","sequence":"additional","affiliation":[{"name":"Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[{"name":"Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Yao","sequence":"additional","affiliation":[{"name":"Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"Sun","sequence":"additional","affiliation":[{"name":"Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Wang","sequence":"additional","affiliation":[{"name":"Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.20524\/aog.2016.0099","article-title":"Management of complex perianal Crohn\u2019s disease","volume":"30","author":"Aguilera-Castro","year":"2017","journal-title":"Ann Gastroenterol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.gastro.2003.08.025","article-title":"AGA technical review on perianal Crohn\u2019s disease","volume":"125","author":"Sandborn","year":"2003","journal-title":"Gastroenterology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1186\/s12955-020-01622-7","article-title":"Burden of disease and adaptation to life in patients with Crohn\u2019s perianal fistula: a qualitative exploration","volume":"18","author":"Adegbola","year":"2020","journal-title":"Health Qual Life Outcomes"},{"key":"B4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1024\/0040-5930\/a000427","article-title":"Perianal Crohn\u2019s disease","volume":"70","author":"Burri","year":"2013","journal-title":"Ther Umsch"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2578","DOI":"10.1097\/JS9.0000000000002238","article-title":"Global trends in surgically based treatment of anal fistula in Crohn\u2019s disease: a bibliometric and visualization analysis","volume":"111","author":"Jin","year":"2025","journal-title":"Int J Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e34817","DOI":"10.1097\/MD.0000000000034817","article-title":"Crohn\u2019s disease from past to present: research trends and global outcomes with scientometric analysis during 1980 to 2022","volume":"102","author":"Karabulut","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1515251","DOI":"10.3389\/fped.2025.1515251","article-title":"Bibliometric analysis of Crohn\u2019s disease in children, 2014\u20132024","volume":"13","author":"Zhu","year":"2025","journal-title":"Front Pediatr"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1322319","DOI":"10.3389\/fphar.2023.1322319","article-title":"A bibliometric and visual analysis of the use of ustekinumab in Crohn\u2019s disease using CiteSpace","volume":"14","author":"Chen","year":"2023","journal-title":"Front Pharmacol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1441785","DOI":"10.3389\/fphar.2024.1441785","article-title":"Worldwide research trends in Crohn\u2019s disease treatment over the past 2 decades: a bibliometric analysis","volume":"15","author":"Xu","year":"2024","journal-title":"Front Pharmacol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e43854","DOI":"10.1097\/MD.0000000000043854","article-title":"Hotspots and trends of perianal fistula of Crohn\u2019s disease: a bibliometric analysis","volume":"104","author":"Liang","year":"2025","journal-title":"Medicine (Baltimore)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.21037\/tgh-23-113","article-title":"Landscape of surgery in Crohn\u2019s disease across twenty years: insights from machine learning","volume":"9","author":"Zhou","year":"2024","journal-title":"Transl Gastroenterol Hepatol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/ajg.2010.343","article-title":"Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort","volume":"106","author":"Vavricka","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"B14","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1002\/ibd.21719","article-title":"Systematic evaluation of risk factors for diagnostic delay in inflammatory bowel disease","volume":"18","author":"Vavricka","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","volume":"140","author":"Cosnes","year":"2011","journal-title":"Gastroenterology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1053\/gast.2002.32362","article-title":"The natural history of fistulizing Crohn\u2019s disease in Olmsted county, Minnesota","volume":"122","author":"Schwartz","year":"2002","journal-title":"Gastroenterology"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/ibd.21261","article-title":"Nonfistulizing perianal Crohn\u2019s disease: clinical features, epidemiology, and treatment","volume":"16","author":"Bouguen","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/BF01648416","article-title":"Current status and influence of operation on perianal Crohn\u2019s disease","volume":"1","author":"Keighley","year":"1986","journal-title":"Int J Colorectal Dis"},{"key":"B19","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/BF02049859","article-title":"Surgery for symptomatic hemorrhoids and anal fissures in Crohn\u2019s disease","volume":"36","author":"Wolkomir","year":"1993","journal-title":"Dis Colon Rectum"},{"key":"B20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/ibd.21674","article-title":"Perianal Crohn\u2019s disease findings other than fistulas in a population-based cohort","volume":"18","author":"Peyrin-Biroulet","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e25090","DOI":"10.1590\/S0004-2803.24612025-090","article-title":"Nutritional assessment and its impact on quality of life in patients with inflammatory bowel disease in Colombia: Nutribd\u2014col","volume":"62","author":"Parra-Izquierdo","year":"2026","journal-title":"Arq Gastroenterol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/DCR.0000000000002325","article-title":"Follow-up study to evaluate the long-term safety and efficacy of darvadstrocel (mesenchymal stem cell treatment) in patients with perianal fistulizing Crohn\u2019s disease: aDMIRE-CD phase 3 randomized controlled trial","volume":"65","author":"Garcia-Olmo","year":"2022","journal-title":"Dis Colon Rectum"},{"key":"B23","doi-asserted-by":"publisher","first-page":"4120","DOI":"10.1182\/blood-2004-02-0586","article-title":"Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells","volume":"105","author":"Jiang","year":"2005","journal-title":"Blood"},{"key":"B24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s00384-012-1581-9","article-title":"Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn\u2019s disease: results from a multicenter phase I\/IIa clinical trial","volume":"28","author":"de la Portilla","year":"2013","journal-title":"Int J Colorectal Dis"},{"key":"B25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.4291\/wjgp.v5.i3.205","article-title":"Pathophysiology of fistula formation in Crohn\u2019s disease","volume":"5","author":"Scharl","year":"2014","journal-title":"World J Gastrointest Pathophysiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.copbio.2012.05.005","article-title":"Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases","volume":"23","author":"DelaRosa","year":"2012","journal-title":"Curr Opin Biotechnol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1136\/gut.24.3.177","article-title":"Toward optimal use of corticosteroids in ulcerative colitis and Crohn\u2019s disease","volume":"24","author":"Lennard-Jones","year":"1983","journal-title":"Gut"},{"key":"B28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","article-title":"3rd European evidence-based consensus on the diagnosis and management of Crohn\u2019s disease 2016: part 1: diagnosis and medical management","volume":"11","author":"Gomoll\u00f3n","year":"2017","journal-title":"J Crohns Colitis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1007\/s10350-005-0052-6","article-title":"A phase I clinical trial of the treatment of Crohn\u2019s fistula by adipose mesenchymal stem cell transplantation","volume":"48","author":"Garc\u00eda-Olmo","year":"2005","journal-title":"Dis Colon Rectum"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3727\/096368910X557245","article-title":"Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis","volume":"20","author":"Liang","year":"2011","journal-title":"Cell Transplant"},{"key":"B31","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1177\/15533506231157167","article-title":"Mesenchymal stem cells versus placebo for perianal fistulizing Crohn\u2019s disease: a systemic review and meta-analysis","volume":"30","author":"Li","year":"2023","journal-title":"Surg Innov"},{"key":"B32","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nrgastro.2017.104","article-title":"Perianal fistulizing Crohn\u2019s disease: pathogenesis, diagnosis and therapy. Nature reviews","volume":"14","author":"Pan\u00e9s","year":"2017","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"B33","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1186\/s12866-023-03084-5","article-title":"Diagnosis of Crohn\u2019s disease and ulcerative colitis using the microbiome","volume":"23","author":"Kang","year":"2023","journal-title":"BMC Microbiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.3748\/wjg.v20.i12.3198","article-title":"Inflammatory bowel disease course in Crohn\u2019s disease: is the natural history changing?","volume":"20","author":"Golovics","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s10151-018-1906-y","article-title":"Management of anoperineal lesions in Crohn\u2019s disease: a French national society of coloproctology national consensus","volume":"22","author":"Bouchard","year":"2018","journal-title":"Tech Coloproctol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/codi.13462","article-title":"Surgical management of fistulating perianal Crohn\u2019s disease: a UK survey","volume":"19","author":"Lee","year":"2017","journal-title":"Colorectal Dis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00423-021-02100-4","article-title":"Management of perianal fistula in inflammatory bowel disease: identification of prognostic factors associated with surgery","volume":"406","author":"de Las Casas","year":"2021","journal-title":"Langenbecks Arch Surg"},{"key":"B38","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/MIB.0000000000000367","article-title":"Guidelines for imaging of Crohn\u2019s perianal fistulizing disease","volume":"21","author":"Ong","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"B39","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/his.12263","article-title":"Ulcerative colitis or Crohn\u2019s disease? Pitfalls and problems","volume":"64","author":"Feakins","year":"2014","journal-title":"Histopathology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/ecco-jcc\/jjz187","article-title":"ECCO Guidelines on therapeutics in Crohn\u2019s disease: surgical treatment","volume":"14","author":"Adamina","year":"2020","journal-title":"J Crohns Colitis"}],"container-title":["Frontiers in Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1624488\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T06:58:30Z","timestamp":1772607510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fsurg.2026.1624488\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":40,"alternative-id":["10.3389\/fsurg.2026.1624488"],"URL":"https:\/\/doi.org\/10.3389\/fsurg.2026.1624488","relation":{},"ISSN":["2296-875X"],"issn-type":[{"value":"2296-875X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]},"article-number":"1624488"}}