{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:40:51Z","timestamp":1773337251014,"version":"3.50.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adenoid cystic carcinoma (ACC) arising in the subglottic larynx is extremely uncommon. Because of its slow but locally invasive and neurotropic growth, diagnosis is often delayed until the tumor becomes advanced. Reporting such cases is valuable for raising clinical awareness and guiding management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case description<\/jats:title>\n                    <jats:p>We describe a 72-year-old woman with a 6-year history of cough and progressive shortness of breath accompanied by intermittent stridor, initially misdiagnosed as chronic pulmonary disease. Her comorbidities included grade-3 hypertension, pulmonary hypertension, fatty liver disease, gallstones, coronary atherosclerosis, pleural thickening, and a left diaphragmatic hernia. Flexible fiberoptic laryngoscopy showed a large pedunculated mass with its base in the subglottic region, prolapsing into and out of the glottis during respiration and nearly obstructing the airway. The airway was secured with an emergency tracheostomy, followed by transoral endoscopic removal using plasma radiofrequency under suspension laryngoscopy. Histopathology confirmed ACC with cribriform and solid patterns (grade II). The patient declined further surgery and radiotherapy; despite repeated contact attempts, no long-term follow-up information was available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Subglottic ACC can mimic lower-airway disease by causing dynamic glottic obstruction. Early laryngoscopic evaluation should be considered in patients with persistent dyspnea unresponsive to conventional treatment. Individualized airway management and, when possible, definitive oncologic therapy are key to improving patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1687106","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:49:15Z","timestamp":1773298155000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Subglottic giant adenoid cystic carcinoma: a case report"],"prefix":"10.3389","volume":"13","author":[{"given":"Chenguang","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Qinghai University","place":["Xining, Qinghai, China"]},{"name":"Department of Otolaryngology, Affiliated Hospital of Qinghai University","place":["Xining, Qinghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenghao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Affiliated Hospital of Qinghai University","place":["Xining, Qinghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-sen University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Pathology Department, Affiliated Hospital of Qinghai University","place":["Xining, Qinghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaohua","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Qinghai University","place":["Xining, Qinghai, China"]},{"name":"Department of Otolaryngology, Affiliated Hospital of Qinghai University","place":["Xining, Qinghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Affiliated Hospital of Qinghai University","place":["Xining, Qinghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.oraloncology.2015.04.005","article-title":"Adenoid cystic carcinoma of the head and neck\u2013an update","volume":"51","author":"Coca-Pelaz","year":"2015","journal-title":"Oral Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"368504241308735","DOI":"10.1177\/00368504241308735","article-title":"Adenoid cystic carcinoma of palatine tonsil: a case report","volume":"107","author":"Guo","year":"2024","journal-title":"Sci Prog"},{"key":"B3","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1631\/jzus.B0920071","article-title":"Subglottic adenoid cystic carcinoma mistaken for asthma","volume":"10","author":"Wang","year":"2009","journal-title":"J Zhejiang Univ Sci B"},{"key":"B4","first-page":"79","article-title":"Laryngeal adenoid cystic carcinoma: a rare case report","volume":"15","author":"Eslami Aliabadi","year":"2022","journal-title":"Int J Clin Exp Pathol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.14639\/0392-100X-N1379","article-title":"Adenoid cystic carcinoma. 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