{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T08:09:35Z","timestamp":1774512575069,"version":"3.50.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The synchronous occurrence of two androgen receptor-positive (AR+) malignancies with overlapping metastatic patterns is exceedingly rare and poses significant diagnostic and therapeutic challenges. Salivary duct carcinoma (SDC) is an aggressive AR\u2009+\u2009tumor with a high propensity for early metastasis, whereas low-risk prostate adenocarcinomas (PCa) are often indolent. We report the first case of a synchronous SDC of the right parotid gland and a low-grade PCa, where the origin of osseous metastatic spread was initially unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 65-year-old male patient presented with progressive right-sided facial palsy and multiple osseous lesions. Initial histopathological assessment of the parotid mass and assignment of the metastases remained inconclusive. After performing a prostate-specific membrane antigen-positron emission tomography\/computed tomography (PSMA-PET-CT) scan, a low-grade prostate adenocarcinoma (PCa) (Gleason 3\u2009+\u20093) was diagnosed. Further pathological and imaging evaluation revealed an AR+, HER2-low, CK7-positive SDC. The extensive skeletal metastases were attributed to the SDC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case shows the diagnostic complexity of synchronous AR\u2009+\u2009malignancies with overlapping metastatic profiles and emphasizes the need for integrated clinical, radiological, and pathological assessment to ensure optimal patient management. It highlights the need to biopsy metastatic bone lesions in cases of SDC\u2014especially in older men\u2014to rule out osseous metastases from more frequent carcinomas such as PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1697475","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:35:54Z","timestamp":1774506954000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: First case of synchronous androgen receptor-positive salivary duct carcinoma and prostate adenocarcinoma"],"prefix":"10.3389","volume":"13","author":[{"given":"Sofia","family":"Kourou","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne","place":["Cologne, 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