{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:39:00Z","timestamp":1773268740405,"version":"3.50.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Composite tissue defects (CTD) of the forearm and hand commonly result from industrial, agricultural, and traffic-related injuries and often involve multiple anatomical structures, making reconstruction challenging. Simple skin-flap coverage may leave deep dead space and fail to restore functional integrity. This study reports our experience using the free anterolateral thigh chimeric muscle flap (ALT-CMF) for CTD reconstruction and evaluates its effectiveness in achieving reliable defect coverage and functional recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients who underwent ALT-CMF reconstruction between February 2018 and January 2023. All patients had CTD of the forearm or hand and were followed for at least six months. Flap viability, postoperative complications, and donor-site outcomes were recorded. Digital functional recovery was assessed using the Total Active Motion (TAM) score. Two-point discrimination (2PD) were used to evaluate sensory recovery in the transplanted skin flaps.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients (15 males, 5 females; mean age 39.40\u2009\u00b1\u20099.90 years) were included. During surgery, the median area of the harvested anterolateral thigh perforator skin flap was 80.0 (66.0\u201399.0)\u2005cm\n                      <jats:sup>2<\/jats:sup>\n                      , while the median area of the muscle flap component was 21.25 (20.00\u201330.00)\u2005cm\n                      <jats:sup>2<\/jats:sup>\n                      . All donor sites were primarily closed. Over a mean follow-up period of 15.30\u2009\u00b1\u20095.78 months, 15 flaps (75.0%) survived uneventfully, while 5 patients (25.0%) developed vascular crisis; four flaps were salvaged after urgent re-exploration, and one experienced complete necrosis. At the six-month follow-up, the mean TAM score was 235.79\u00b0\u2009\u00b1\u20098.35\u00b0, indicating satisfactory recovery of digital mobility. 2PD testing demonstrated no significant difference in sensory recovery between the transplanted flaps and the contralateral side (19.42\u2009\u00b1\u20092.59\u2005mm vs. 18.16\u2009\u00b1\u20093.20\u2005mm,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.063).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ALT-CMF is an effective reconstructive option for composite tissue defects of the forearm and hand. By providing reliable soft-tissue coverage, eliminating dead space through its chimeric muscle component, and supporting functional restoration in terms of joint mobility and sensation. This technique enables one-stage reconstruction with low donor-site morbidity and promotes favorable limb recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1748013","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:51:43Z","timestamp":1773211903000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical application of the free anterolateral thigh chimeric muscle flap for reconstruction of composite tissue defects of the forearm and hand"],"prefix":"10.3389","volume":"13","author":[{"given":"Shunan","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Upper Extremity Trauma, Reconstruction and Plastic Surgery, Beijing Jishuitan Hospital Guizhou Hospital","place":["Guiyang, China"]},{"name":"Department of Joint Surgery, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Guangzhou Heping Orthopedic Hospital","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongyu","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Guangzhou Heping Orthopedic Hospital","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hand Surgery, Guangzhou Heping Orthopedic Hospital","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The People's Hospital of Guangxi Zhuang Autonomous Region","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qikai","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.1111\/iwj.14029","article-title":"Repair of complex digital soft-tissue defects using a free composite ulnar artery perforator flap from the volar wrist","volume":"20","author":"Qi","year":"2023","journal-title":"Int Wound J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e5182","DOI":"10.1097\/GOX.0000000000005182","article-title":"Functional chimeric double-barrel fibula and reinnervated peroneus Brevis osteomyocutaneous flap for one-stage forearm 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