{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:04:48Z","timestamp":1770145488265,"version":"3.49.0"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Surg."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To correlate the Osteoporosis Self-assessment Tool for Asians (OSTA) index with lumbar QCT-measured bone mineral density (BMD) and bone mineral content (BMC), and assess its utility in evaluating lumbar spine BMD\/BMC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From Jan 2023 to Jun 2024, 366 patients scheduled for lumbar spine surgery were enrolled. All underwent lumbar CT, QCT, and DXA. Spearman correlation analyzed OSTA vs. QCT-BMD and QCT-BMC. Patients were categorized by DXA T-scores into osteoporotic or non-osteoporotic groups. ROC curves were plotted to determine AUC, optimal cutoff, sensitivity, and specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The OSTA index showed a moderate, statistically significant correlation with QCT-BMD and QCT-BMC (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.01). Based on DXA diagnosis, QCT-BMC yielded AUCs of 0.712 (men) and 0.745 (women) for osteoporosis, indicating moderate diagnostic value. The optimal cutoffs were 663.86\u2005mg for men and 521.65\u2005mg for women, with sensitivities of 57.6% and 59.5%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As a screening tool, the OSTA index can help identify high-risk individuals undergoing spinal surgery who are likely to have low lumbar trabecular BMD and BMC as measured by QCT. Diagnostic thresholds for osteoporosis may be set at lumbar QCT-BMC &amp;lt;663.86\u2005mg in men or &amp;lt;521.65 mg in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fsurg.2026.1752041","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T07:08:06Z","timestamp":1770102486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between the osteoporosis self-assessment tool for Asians index and QCT-derived bone parameters: a cross-sectional analysis of lumbar spine mineral density and content"],"prefix":"10.3389","volume":"13","author":[{"given":"Cheng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"155638","DOI":"10.1016\/j.metabol.2023.155638","article-title":"Sarcopenia, osteoporosis and frailty","volume":"145","author":"Gielen","year":"2023","journal-title":"Metab Clin Exp"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician\u2019s guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos Int"},{"key":"B3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.clnesp.2024.10.001","article-title":"Current status and dilemmas of osteoporosis screening tools: a narrative review","volume":"64","author":"Zhang","year":"2024","journal-title":"Clin Nutr ESPEN"},{"key":"B4","doi-asserted-by":"publisher","first-page":"436","DOI":"10.3171\/2022.11.SPINE22875","article-title":"Alternatives to DEXA for the assessment of bone density: a systematic review of the literature and future recommendations","volume":"38","author":"Deshpande","year":"2023","journal-title":"J Neurosurg Spine"},{"key":"B5","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1080\/00325481.2017.1353394","article-title":"A review on the performance of osteoporosis self-assessment tool for asians in determining osteoporosis and fracture risk","volume":"129","author":"Chin","year":"2017","journal-title":"Postgrad Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1186\/s13018-024-05260-3","article-title":"Combining OSTA and BMR to predict osteoporosis in Chinese population","volume":"19","author":"Zhao","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jot.2018.11.003","article-title":"Discordance in diagnosis of osteoporosis by quantitative computed tomography and dual-energy x-ray absorptiometry in Chinese elderly men","volume":"18","author":"Xu","year":"2018","journal-title":"J Orthop Translat"},{"key":"B8","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jconrel.2022.06.068","article-title":"An engineered dual function peptide to repair fractured bones","volume":"350","author":"Low","year":"2022","journal-title":"J Control Release"},{"key":"B9","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s11657-022-01061-5","article-title":"UK Clinical guideline for the prevention and treatment of osteoporosis","volume":"17","author":"Gregson","year":"2022","journal-title":"Arch Osteoporos"},{"key":"B10","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jocd.2014.04.119","article-title":"Axial QCT: clinical applications and new developments","volume":"17","author":"Link","year":"2014","journal-title":"J Clin Densitom"},{"key":"B11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s11657-022-01159-w","article-title":"OSTA As a screening tool to predict osteoporosis in Indian postmenopausal women - 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